Gene-Environment Interactions for Metals

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverk

Standard

Gene-Environment Interactions for Metals. / Broberg, Karin; Engström, Karin; Ameer, Shegufta.

Handbook on the Toxicology of Metals. red. / Gunnar Nordberg; Bruce Fowler; Monica Nordberg. Vol. 1 4th. uppl. Elsevier Inc., 2014. s. 239-264.

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverk

Harvard

Broberg, K, Engström, K & Ameer, S 2014, Gene-Environment Interactions for Metals. i G Nordberg, B Fowler & M Nordberg (red), Handbook on the Toxicology of Metals. 4th uppl, vol. 1, Elsevier Inc., s. 239-264. https://doi.org/10.1016/B978-0-444-59453-2.00012-3

APA

Broberg, K., Engström, K., & Ameer, S. (2014). Gene-Environment Interactions for Metals. I G. Nordberg, B. Fowler, & M. Nordberg (Red.), Handbook on the Toxicology of Metals (4th uppl., Vol. 1, s. 239-264). Elsevier Inc.. https://doi.org/10.1016/B978-0-444-59453-2.00012-3

CBE

Broberg K, Engström K, Ameer S. 2014. Gene-Environment Interactions for Metals. Nordberg G, Fowler B, Nordberg M, redaktörer. I Handbook on the Toxicology of Metals. 4th uppl. Elsevier Inc. s. 239-264. https://doi.org/10.1016/B978-0-444-59453-2.00012-3

MLA

Broberg, Karin, Karin Engström och Shegufta Ameer "Gene-Environment Interactions for Metals"., Nordberg, Gunnar Fowler, Bruce Nordberg, Monica (redaktörer). Handbook on the Toxicology of Metals. 4th uppl., Kapitel 12, Elsevier Inc. 2014, 239-264. https://doi.org/10.1016/B978-0-444-59453-2.00012-3

Vancouver

Broberg K, Engström K, Ameer S. Gene-Environment Interactions for Metals. I Nordberg G, Fowler B, Nordberg M, redaktörer, Handbook on the Toxicology of Metals. 4th uppl. Vol. 1. Elsevier Inc. 2014. s. 239-264 https://doi.org/10.1016/B978-0-444-59453-2.00012-3

Author

Broberg, Karin ; Engström, Karin ; Ameer, Shegufta. / Gene-Environment Interactions for Metals. Handbook on the Toxicology of Metals. redaktör / Gunnar Nordberg ; Bruce Fowler ; Monica Nordberg. Vol. 1 4th. uppl. Elsevier Inc., 2014. s. 239-264

RIS

TY - CHAP

T1 - Gene-Environment Interactions for Metals

AU - Broberg, Karin

AU - Engström, Karin

AU - Ameer, Shegufta

PY - 2014/10/28

Y1 - 2014/10/28

N2 - It has become increasingly clear that the individual genetic background influences susceptibility to metal toxicity. Genetic variation in genes that regulate metal toxicokinetics and toxicodynamics influence the degree of metal accumulation and retention in the body, as well as toxic effects. Moreover, factors that regulate gene expression, so-called epigenetic factors, have been identified as targets for metal toxicity. This chapter addresses what is currently known about such gene-environment interactions. The picture that emerges for most metals is that the genetic influence is probably not attributed to a single gene for each metal; rather it is polygenic, with some genes having a stronger effect than others. The presence of variants of the human leukocyte antigen system and the risk of beryllium-related pulmonary disease was one of the first and maybe the strongest example of a gene-environment interaction. There are also clear gene-environment interactions for arsenic and lead. Evidence is rapidly growing for epigenetic effects of metals, e.g. for arsenic, cadmium, and lead, which may explain the association between metal exposure early in life and toxic effects later in life, as well as metal carcinogenicity.

AB - It has become increasingly clear that the individual genetic background influences susceptibility to metal toxicity. Genetic variation in genes that regulate metal toxicokinetics and toxicodynamics influence the degree of metal accumulation and retention in the body, as well as toxic effects. Moreover, factors that regulate gene expression, so-called epigenetic factors, have been identified as targets for metal toxicity. This chapter addresses what is currently known about such gene-environment interactions. The picture that emerges for most metals is that the genetic influence is probably not attributed to a single gene for each metal; rather it is polygenic, with some genes having a stronger effect than others. The presence of variants of the human leukocyte antigen system and the risk of beryllium-related pulmonary disease was one of the first and maybe the strongest example of a gene-environment interaction. There are also clear gene-environment interactions for arsenic and lead. Evidence is rapidly growing for epigenetic effects of metals, e.g. for arsenic, cadmium, and lead, which may explain the association between metal exposure early in life and toxic effects later in life, as well as metal carcinogenicity.

KW - Copy number variation

KW - DNA methylation

KW - Effect modification

KW - Epigenetic

KW - Histone modification

KW - MicroRNA

KW - Polymorphisms SNP

KW - Susceptibility

U2 - 10.1016/B978-0-444-59453-2.00012-3

DO - 10.1016/B978-0-444-59453-2.00012-3

M3 - Book chapter

SN - 9780444594532

VL - 1

SP - 239

EP - 264

BT - Handbook on the Toxicology of Metals

A2 - Nordberg, Gunnar

A2 - Fowler, Bruce

A2 - Nordberg, Monica

PB - Elsevier Inc.

ER -