Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p.G2019S mutation in the LRRK2 gene

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Bibtex

@article{0d8837db8d0446098faaa7e22a98562c,
title = "Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p.G2019S mutation in the LRRK2 gene",
abstract = "The leucine-rich repeat kinase 2 (LRRK2) p.G2019S mutation is the most common genetic cause of Parkinson's disease (PD). An induced pluripotent stem cell (iPSC) line CSC-41 was generated from a 75-year old patient diagnosed with PD caused by a p.G2019S mutation in LRRK2. Skin fibroblasts were reprogrammed using a non-integrating Sendai virus-based technology to deliver OCT3/4, SOX2, c-MYC and KLF4 transcription factors. The generated iPSC line exhibits expression of common pluripotency markers, differentiates into the three germ layers and has a normal karyotype. The iPSC line can be used to explore the association between LRRK2 mutation and PD.",
author = "Ana Marote and Yuriy Pomeshchik and Anna Collin and Stefano Goldwurm and Lamas, {Nuno J.} and Lu{\'i}sa Pinto and Salgado, {Ant{\'o}nio J.} and Laurent Roybon",
year = "2018",
month = "4",
day = "1",
doi = "10.1016/j.scr.2018.01.022",
language = "English",
volume = "28",
pages = "44--47",
journal = "Stem Cell Research",
issn = "1876-7753",
publisher = "Elsevier",

}