Genes encoding for AP-2 beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Genes encoding for AP-2 beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance. / Nilsson, Kent W.; Damberg, Mattias; Ohrvik, John; Leppert, Jerzy; Lindstrom, Leif; Anckarsäter, Henrik; Oreland, Lars.

I: Neuroscience Letters, Vol. 411, Nr. 3, 2007, s. 233-237.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Nilsson, KW, Damberg, M, Ohrvik, J, Leppert, J, Lindstrom, L, Anckarsäter, H & Oreland, L 2007, 'Genes encoding for AP-2 beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance', Neuroscience Letters, vol. 411, nr. 3, s. 233-237. https://doi.org/10.1016/j.neulet.2006.10.051

APA

Nilsson, K. W., Damberg, M., Ohrvik, J., Leppert, J., Lindstrom, L., Anckarsäter, H., & Oreland, L. (2007). Genes encoding for AP-2 beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance. Neuroscience Letters, 411(3), 233-237. https://doi.org/10.1016/j.neulet.2006.10.051

CBE

MLA

Vancouver

Author

Nilsson, Kent W. ; Damberg, Mattias ; Ohrvik, John ; Leppert, Jerzy ; Lindstrom, Leif ; Anckarsäter, Henrik ; Oreland, Lars. / Genes encoding for AP-2 beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance. I: Neuroscience Letters. 2007 ; Vol. 411, Nr. 3. s. 233-237.

RIS

TY - JOUR

T1 - Genes encoding for AP-2 beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance

AU - Nilsson, Kent W.

AU - Damberg, Mattias

AU - Ohrvik, John

AU - Leppert, Jerzy

AU - Lindstrom, Leif

AU - Anckarsäter, Henrik

AU - Oreland, Lars

PY - 2007

Y1 - 2007

N2 - In several twin studies the relative contribution of genetic factors for personality traits has amounted to figures between 40 and 60%. In the present study we investigated to which degree polymorphisms in the 5-HTT and AP-2 beta genes are implicated in the neural processes involved in the formation of Temperament and Character traits, as estimated by Cloninger's TCI. Considering the background of previous reports, associations with the character Self-Transcendence and its sub-scale Spiritual Acceptance in particular, were of interest. A stratified random sample of 200 individuals (total population = 5173), matched for age, gender and risk behaviors, from volunteering 16- and 19-year-old adolescents students in Sweden was investigated. Cloninger's TCI inventory was used for investigation of temperament and character traits. Blood samples were used for analyses of a promoter serotonin transporter polymorphism (5-HTTLPR) and an intron 2 polymorphism in the transcription factor AP-2 beta gene. Among boys individuals with presence of the short 5-HTTLPR genotype showed lower scores, whereas individuals with presence of the short AP-2 beta genotype showed higher scores of personality character Self-Transcendence and its sub-scale Spiritual Acceptance. Among girls no effect of either genotype was found. Both among boys and girls, significant interactive effects were found between 5-HTTLPR and AP-2 beta genotypes, with regard to Self-Transcendence and Spiritual acceptance. Boys and girls with the combination of presence of the short 5-HTTLPR, and homozygosity for the long AP-2 beta genotype scored significantly lower on Self-Transcendence and Spiritual Acceptance. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

AB - In several twin studies the relative contribution of genetic factors for personality traits has amounted to figures between 40 and 60%. In the present study we investigated to which degree polymorphisms in the 5-HTT and AP-2 beta genes are implicated in the neural processes involved in the formation of Temperament and Character traits, as estimated by Cloninger's TCI. Considering the background of previous reports, associations with the character Self-Transcendence and its sub-scale Spiritual Acceptance in particular, were of interest. A stratified random sample of 200 individuals (total population = 5173), matched for age, gender and risk behaviors, from volunteering 16- and 19-year-old adolescents students in Sweden was investigated. Cloninger's TCI inventory was used for investigation of temperament and character traits. Blood samples were used for analyses of a promoter serotonin transporter polymorphism (5-HTTLPR) and an intron 2 polymorphism in the transcription factor AP-2 beta gene. Among boys individuals with presence of the short 5-HTTLPR genotype showed lower scores, whereas individuals with presence of the short AP-2 beta genotype showed higher scores of personality character Self-Transcendence and its sub-scale Spiritual Acceptance. Among girls no effect of either genotype was found. Both among boys and girls, significant interactive effects were found between 5-HTTLPR and AP-2 beta genotypes, with regard to Self-Transcendence and Spiritual acceptance. Boys and girls with the combination of presence of the short 5-HTTLPR, and homozygosity for the long AP-2 beta genotype scored significantly lower on Self-Transcendence and Spiritual Acceptance. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

KW - transcription

KW - factor AP-2

KW - serotonin

KW - adolescent

KW - personality

KW - spirituality

KW - genes

U2 - 10.1016/j.neulet.2006.10.051

DO - 10.1016/j.neulet.2006.10.051

M3 - Article

VL - 411

SP - 233

EP - 237

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -