Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Recent genome-wide association studies (GWASs) conducted in Asian populations have identified novel risk loci for systemic lupus erythematosus (SLE). Here, we genotyped 10 single-nucleotide polymorphisms (SNPs) in eight such loci and investigated their disease associations in three independent Caucasian SLE case-control cohorts recruited from Sweden, Finland and the United States. The disease associations of the SNPs in ETS1, IKZF1, LRRC18-WDFY4, RASGRP3, SLC15A4, TNIP1 and 16p11.2 were replicated, whereas no solid evidence of association was observed for the 7q11.23 locus in the Caucasian cohorts. SLC15A4 was significantly associated with renal involvement in SLE. The association of TNIP1 was more pronounced in SLE patients with renal and immunological disorder, which is corroborated by two previous studies in Asian cohorts. The effects of all the associated SNPs, either conferring risk for or being protective against SLE, were in the same direction in Caucasians and Asians. The magnitudes of the allelic effects for most of the SNPs were also comparable across different ethnic groups. On the contrary, remarkable differences in allele frequencies between Caucasian and Asian populations were observed for all associated SNPs. In conclusion, most of the novel SLE risk loci identified by GWASs in Asian populations were also associated with SLE in Caucasian populations. We observed both similarities and differences with respect to the effect sizes and risk allele frequencies across ethnicities.

Detaljer

Författare
  • Chuan Wang
  • Annika Ahlford
  • Tiina M. Jarvinen
  • Gunnel Nordmark
  • Maija-Leena Eloranta
  • Iva Gunnarsson
  • Elisabet Svenungsson
  • Leonid Padyukov
  • Gunnar Sturfelt
  • Lennart Truedsson
  • Catharina Eriksson
  • Solbritt Rantapaa-Dahlqvist
  • Christopher Sjowall
  • Heikki Julkunen
  • Lindsey A. Criswell
  • Robert R. Graham
  • Timothy W. Behrens
  • Juha Kere
  • Lars Ronnblom
  • Ann-Christine Syvanen
  • Johanna K. Sandling
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk genetik

Nyckelord

Originalspråkengelska
Sidor (från-till)994-999
TidskriftEuropean Journal of Human Genetics
Volym21
Utgivningsnummer9
StatusPublished - 2013
PublikationskategoriForskning
Peer review utfördJa