Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


title = "Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations",
abstract = "Recent genome-wide association studies (GWASs) conducted in Asian populations have identified novel risk loci for systemic lupus erythematosus (SLE). Here, we genotyped 10 single-nucleotide polymorphisms (SNPs) in eight such loci and investigated their disease associations in three independent Caucasian SLE case-control cohorts recruited from Sweden, Finland and the United States. The disease associations of the SNPs in ETS1, IKZF1, LRRC18-WDFY4, RASGRP3, SLC15A4, TNIP1 and 16p11.2 were replicated, whereas no solid evidence of association was observed for the 7q11.23 locus in the Caucasian cohorts. SLC15A4 was significantly associated with renal involvement in SLE. The association of TNIP1 was more pronounced in SLE patients with renal and immunological disorder, which is corroborated by two previous studies in Asian cohorts. The effects of all the associated SNPs, either conferring risk for or being protective against SLE, were in the same direction in Caucasians and Asians. The magnitudes of the allelic effects for most of the SNPs were also comparable across different ethnic groups. On the contrary, remarkable differences in allele frequencies between Caucasian and Asian populations were observed for all associated SNPs. In conclusion, most of the novel SLE risk loci identified by GWASs in Asian populations were also associated with SLE in Caucasian populations. We observed both similarities and differences with respect to the effect sizes and risk allele frequencies across ethnicities.",
keywords = "systemic lupus erythematosus, genetic-association study, Asian, Caucasian",
author = "Chuan Wang and Annika Ahlford and Jarvinen, {Tiina M.} and Gunnel Nordmark and Maija-Leena Eloranta and Iva Gunnarsson and Elisabet Svenungsson and Leonid Padyukov and Gunnar Sturfelt and Andreas J{\"o}nsen and Anders Bengtsson and Lennart Truedsson and Catharina Eriksson and Solbritt Rantapaa-Dahlqvist and Christopher Sjowall and Heikki Julkunen and Criswell, {Lindsey A.} and Graham, {Robert R.} and Behrens, {Timothy W.} and Juha Kere and Lars Ronnblom and Ann-Christine Syvanen and Sandling, {Johanna K.}",
year = "2013",
doi = "10.1038/ejhg.2012.277",
language = "English",
volume = "21",
pages = "994--999",
journal = "European Journal of Human Genetics",
issn = "1476-5438",
publisher = "Nature Publishing Group",
number = "9",