Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

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Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations. / Wang, Chuan; Ahlford, Annika; Jarvinen, Tiina M.; Nordmark, Gunnel; Eloranta, Maija-Leena; Gunnarsson, Iva; Svenungsson, Elisabet; Padyukov, Leonid; Sturfelt, Gunnar; Jönsen, Andreas; Bengtsson, Anders; Truedsson, Lennart; Eriksson, Catharina; Rantapaa-Dahlqvist, Solbritt; Sjowall, Christopher; Julkunen, Heikki; Criswell, Lindsey A.; Graham, Robert R.; Behrens, Timothy W.; Kere, Juha; Ronnblom, Lars; Syvanen, Ann-Christine; Sandling, Johanna K.

I: European Journal of Human Genetics, Vol. 21, Nr. 9, 2013, s. 994-999.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Wang, C, Ahlford, A, Jarvinen, TM, Nordmark, G, Eloranta, M-L, Gunnarsson, I, Svenungsson, E, Padyukov, L, Sturfelt, G, Jönsen, A, Bengtsson, A, Truedsson, L, Eriksson, C, Rantapaa-Dahlqvist, S, Sjowall, C, Julkunen, H, Criswell, LA, Graham, RR, Behrens, TW, Kere, J, Ronnblom, L, Syvanen, A-C & Sandling, JK 2013, 'Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations', European Journal of Human Genetics, vol. 21, nr. 9, s. 994-999. https://doi.org/10.1038/ejhg.2012.277

APA

Wang, C., Ahlford, A., Jarvinen, T. M., Nordmark, G., Eloranta, M-L., Gunnarsson, I., ... Sandling, J. K. (2013). Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations. European Journal of Human Genetics, 21(9), 994-999. https://doi.org/10.1038/ejhg.2012.277

CBE

Wang C, Ahlford A, Jarvinen TM, Nordmark G, Eloranta M-L, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson A, Truedsson L, Eriksson C, Rantapaa-Dahlqvist S, Sjowall C, Julkunen H, Criswell LA, Graham RR, Behrens TW, Kere J, Ronnblom L, Syvanen A-C, Sandling JK. 2013. Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations. European Journal of Human Genetics. 21(9):994-999. https://doi.org/10.1038/ejhg.2012.277

MLA

Vancouver

Author

Wang, Chuan ; Ahlford, Annika ; Jarvinen, Tiina M. ; Nordmark, Gunnel ; Eloranta, Maija-Leena ; Gunnarsson, Iva ; Svenungsson, Elisabet ; Padyukov, Leonid ; Sturfelt, Gunnar ; Jönsen, Andreas ; Bengtsson, Anders ; Truedsson, Lennart ; Eriksson, Catharina ; Rantapaa-Dahlqvist, Solbritt ; Sjowall, Christopher ; Julkunen, Heikki ; Criswell, Lindsey A. ; Graham, Robert R. ; Behrens, Timothy W. ; Kere, Juha ; Ronnblom, Lars ; Syvanen, Ann-Christine ; Sandling, Johanna K. / Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations. I: European Journal of Human Genetics. 2013 ; Vol. 21, Nr. 9. s. 994-999.

RIS

TY - JOUR

T1 - Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

AU - Wang, Chuan

AU - Ahlford, Annika

AU - Jarvinen, Tiina M.

AU - Nordmark, Gunnel

AU - Eloranta, Maija-Leena

AU - Gunnarsson, Iva

AU - Svenungsson, Elisabet

AU - Padyukov, Leonid

AU - Sturfelt, Gunnar

AU - Jönsen, Andreas

AU - Bengtsson, Anders

AU - Truedsson, Lennart

AU - Eriksson, Catharina

AU - Rantapaa-Dahlqvist, Solbritt

AU - Sjowall, Christopher

AU - Julkunen, Heikki

AU - Criswell, Lindsey A.

AU - Graham, Robert R.

AU - Behrens, Timothy W.

AU - Kere, Juha

AU - Ronnblom, Lars

AU - Syvanen, Ann-Christine

AU - Sandling, Johanna K.

PY - 2013

Y1 - 2013

N2 - Recent genome-wide association studies (GWASs) conducted in Asian populations have identified novel risk loci for systemic lupus erythematosus (SLE). Here, we genotyped 10 single-nucleotide polymorphisms (SNPs) in eight such loci and investigated their disease associations in three independent Caucasian SLE case-control cohorts recruited from Sweden, Finland and the United States. The disease associations of the SNPs in ETS1, IKZF1, LRRC18-WDFY4, RASGRP3, SLC15A4, TNIP1 and 16p11.2 were replicated, whereas no solid evidence of association was observed for the 7q11.23 locus in the Caucasian cohorts. SLC15A4 was significantly associated with renal involvement in SLE. The association of TNIP1 was more pronounced in SLE patients with renal and immunological disorder, which is corroborated by two previous studies in Asian cohorts. The effects of all the associated SNPs, either conferring risk for or being protective against SLE, were in the same direction in Caucasians and Asians. The magnitudes of the allelic effects for most of the SNPs were also comparable across different ethnic groups. On the contrary, remarkable differences in allele frequencies between Caucasian and Asian populations were observed for all associated SNPs. In conclusion, most of the novel SLE risk loci identified by GWASs in Asian populations were also associated with SLE in Caucasian populations. We observed both similarities and differences with respect to the effect sizes and risk allele frequencies across ethnicities.

AB - Recent genome-wide association studies (GWASs) conducted in Asian populations have identified novel risk loci for systemic lupus erythematosus (SLE). Here, we genotyped 10 single-nucleotide polymorphisms (SNPs) in eight such loci and investigated their disease associations in three independent Caucasian SLE case-control cohorts recruited from Sweden, Finland and the United States. The disease associations of the SNPs in ETS1, IKZF1, LRRC18-WDFY4, RASGRP3, SLC15A4, TNIP1 and 16p11.2 were replicated, whereas no solid evidence of association was observed for the 7q11.23 locus in the Caucasian cohorts. SLC15A4 was significantly associated with renal involvement in SLE. The association of TNIP1 was more pronounced in SLE patients with renal and immunological disorder, which is corroborated by two previous studies in Asian cohorts. The effects of all the associated SNPs, either conferring risk for or being protective against SLE, were in the same direction in Caucasians and Asians. The magnitudes of the allelic effects for most of the SNPs were also comparable across different ethnic groups. On the contrary, remarkable differences in allele frequencies between Caucasian and Asian populations were observed for all associated SNPs. In conclusion, most of the novel SLE risk loci identified by GWASs in Asian populations were also associated with SLE in Caucasian populations. We observed both similarities and differences with respect to the effect sizes and risk allele frequencies across ethnicities.

KW - systemic lupus erythematosus

KW - genetic-association study

KW - Asian

KW - Caucasian

U2 - 10.1038/ejhg.2012.277

DO - 10.1038/ejhg.2012.277

M3 - Article

VL - 21

SP - 994

EP - 999

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

SN - 1476-5438

IS - 9

ER -