Genetic risk of progression to type 2 diabetes and response to intensive lifestyle or metformin in prediabetic women with and without a history of gestational diabetes mellitus

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


OBJECTIVE: The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention. Among women in the DPP, diabetes risk reduction with metformin was greater in women with prior gestational diabetes mellitus (GDM) compared with women without GDM but with one or more previous live births. RESEARCH DESIGN AND METHODS: We asked if genetic variability could account for these differences by comparing β-cell function and genetic risk scores (GRS), calculated from 34 diabetes-associated loci, between women with and without histories of GDM. RESULTS: β-Cell function was reduced in women with GDM. The GRS was positively associated with a history of GDM; however, the GRS did not predict progression to diabetes or modulate response to intervention. CONCLUSIONS: These data suggest that a diabetes-associated GRS is associated with development of GDM and may characterize women at risk for development of diabetes due to β-cell dysfunction.


  • Shannon D. Sullivan
  • Kathleen A. Jablonski
  • Jose C. Florez
  • Dana Dabelea
  • Paul W. Franks
  • Sam Dagogo-Jack
  • Catherine Kim
  • William C. Knowler
  • Costas A. Christophi
  • Robert Ratner
Enheter & grupper
Externa organisationer
  • MedStar Washington Hospital Center
  • George Washington University
  • Massachusetts General Hospital
  • Broad Institute
  • Harvard Medical School
  • Colorado School of Public Health
  • Skåne University Hospital
  • Harvard University
  • Umeå University
  • University of Tennessee
  • University of Michigan
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • American Diabetes Association

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Endokrinologi och diabetes
Sidor (från-till)909-911
Antal sidor3
TidskriftDiabetes Care
StatusPublished - 2014 jan 1
Peer review utfördJa