Genetic studies of body mass index yield new insights for obesity biology.

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title = "Genetic studies of body mass index yield new insights for obesity biology.",
abstract = "Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7{\%} of BMI variation, and genome-wide estimates suggest that common variation accounts for >20{\%} of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.",
keywords = "Polymorphism, Obesity: metabolism, Obesity: genetics, Insulin: secretion, Insulin: metabolism, Glutamic Acid: metabolism, Genetic Predisposition to Disease: genetics, Europe: ethnology, Energy Metabolism: genetics, Continental Population Groups: genetics, Adipogenesis: genetics, Adiposity: genetics, Single Nucleotide: genetics, Quantitative Trait Loci: genetics, Synapses: metabolism",
author = "Locke, {Adam E} and Bratati Kahali and Berndt, {Sonja I} and Justice, {Anne E} and Pers, {Tune H} and Day, {Felix R} and Corey Powell and Sailaja Vedantam and Buchkovich, {Martin L} and Jian Yang and Croteau-Chonka, {Damien C} and Tonu Esko and Tove Fall and Teresa Ferreira and Stefan Gustafsson and Zolt{\'a}n Kutalik and Jian'an Luan and Reedik M{\"a}gi and Randall, {Joshua C} and Winkler, {Thomas W} and Wood, {Andrew R} and Tsegaselassie Workalemahu and Faul, {Jessica D} and Smith, {Jennifer A} and {Hua Zhao}, Jing and Wei Zhao and Jin Chen and Rudolf Fehrmann and Hedman, {{\AA}sa K} and Juha Karjalainen and Schmidt, {Ellen M} and Devin Absher and Najaf Amin and Denise Anderson and Marian Beekman and Bolton, {Jennifer L} and Bragg-Gresham, {Jennifer L} and Steven Buyske and Ayse Demirkan and Guohong Deng and Ehret, {Georg B} and Bjarke Feenstra and Feitosa, {Mary F} and Krista Fischer and Anuj Goel and Jian Gong and Jackson, {Anne U} and Stavroula Kanoni and Kleber, {Marcus E} and Kati Kristiansson and Unhee Lim and Vaneet Lotay and Massimo Mangino and {Mateo Leach}, Irene and Carolina Medina-Gomez and Medland, {Sarah E} and Nalls, {Michael A} and Palmer, {Cameron D} and Dorota Pasko and Sonali Pechlivanis and Peters, {Marjolein J} and Inga Prokopenko and Dmitry Shungin and Alena Stanč{\'a}kov{\'a} and Strawbridge, {Rona J} and {Ju Sung}, Yun and Toshiko Tanaka and Alexander Teumer and Stella Trompet and {van der Laan}, {Sander W} and {van Setten}, Jessica and {Van Vliet-Ostaptchouk}, {Jana V} and Zhaoming Wang and Lo{\"i}c Yengo and Weihua Zhang and Aaron Isaacs and Eva Albrecht and Johan {\"A}rnl{\"o}v and Arscott, {Gillian M} and Attwood, {Antony P} and Stefania Bandinelli and Amy Barrett and Bas, {Isabelita N} and Claire Bellis and Bennett, {Amanda J} and Christian Berne and Roza Blagieva and Matthias Bl{\"u}her and Stefan B{\"o}hringer and Bonnycastle, {Lori L} and Yvonne B{\"o}ttcher and Boyd, {Heather A} and Marcel Bruinenberg and Caspersen, {Ida H} and {Ida Chen}, Yii-Der and Robert Clarke and Daw, {E Warwick} and {de Craen}, {Anton J M} and Graciela Delgado and Maria Dimitriou and Doney, {Alex S F} and Niina Eklund and Karol Estrada and Elodie Eury and Lasse Folkersen and Fraser, {Ross M} and Garcia, {Melissa E} and Frank Geller and Vilmantas Giedraitis and Bruna Gigante and Go, {Alan S} and Alain Golay and Goodall, {Alison H} and Gordon, {Scott D} and Mathias Gorski and Hans-J{\"o}rgen Grabe and Harald Grallert and Grammer, {Tanja B} and J{\"u}rgen Gr{\"a}{\ss}ler and Henrik Gr{\"o}nberg and Groves, {Christopher J} and Ga{\"e}lle Gusto and Jeffrey Haessler and Per Hall and Toomas Haller and Goran Hallmans and Hartman, {Catharina A} and Maija Hassinen and Caroline Hayward and Heard-Costa, {Nancy L} and Quinta Helmer and Christian Hengstenberg and Oddgeir Holmen and Jouke-Jan Hottenga and James, {Alan L} and Jeff, {Janina M} and {\AA}sa Johansson and Jennifer Jolley and Thorhildur Juliusdottir and Leena Kinnunen and Wolfgang Koenig and Markku Koskenvuo and Wolfgang Kratzer and Jaana Laitinen and Claudia Lamina and Karin Leander and Lee, {Nanette R} and Peter Lichtner and Lars Lind and Jaana Lindstr{\"o}m and {Sin Lo}, Ken and St{\'e}phane Lobbens and Roberto Lorbeer and Yingchang Lu and Fran{\cc}ois Mach and Magnusson, {Patrik K E} and Anubha Mahajan and McArdle, {Wendy L} and Stela McLachlan and Cristina Menni and Sigrun Merger and Evelin Mihailov and Lili Milani and Alireza Moayyeri and Monda, {Keri L} and Morken, {Mario A} and Antonella Mulas and Gabriele M{\"u}ller and Martina M{\"u}ller-Nurasyid and Musk, {Arthur W} and Ramaiah Nagaraja and N{\"o}then, {Markus M} and Nolte, {Ilja M} and Stefan Pilz and Rayner, {Nigel W} and Frida Renstr{\"o}m and Rainer Rettig and Ried, {Janina S} and Stephan Ripke and Robertson, {Neil R} and Rose, {Lynda M} and Serena Sanna and Hubert Scharnagl and Salome Scholtens and Schumacher, {Fredrick R} and Scott, {William R} and Thomas Seufferlein and Jianxin Shi and {Vernon Smith}, Albert and Joanna Smolonska and Stanton, {Alice V} and Valgerdur Steinthorsdottir and Kathleen Stirrups and Stringham, {Heather M} and Johan Sundstr{\"o}m and Swertz, {Morris A} and Swift, {Amy J} and Ann-Christine Syv{\"a}nen and Sian-Tsung Tan and Tayo, {Bamidele O} and Barbara Thorand and Gudmar Thorleifsson and Tyrer, {Jonathan P} and Hae-Won Uh and Liesbeth Vandenput and Verhulst, {Frank C} and Vermeulen, {Sita H} and Niek Verweij and Vonk, {Judith M} and Waite, {Lindsay L} and Warren, {Helen R} and Dawn Waterworth and Weedon, {Michael N} and Wilkens, {Lynne R} and Christina Willenborg and Tom Wilsgaard and Wojczynski, {Mary K} and Andrew Wong and Wright, {Alan F} and Qunyuan Zhang and Brennan, {Eoin P} and Murim Choi and Zari Dastani and Drong, {Alexander W} and Per Eriksson and Anders Franco-Cereceda and G{\aa}din, {Jesper R} and Gharavi, {Ali G} and Goddard, {Michael E} and Handsaker, {Robert E} and Jinyan Huang and Fredrik Karpe and Sekar Kathiresan and Sarah Keildson and Krzysztof Kiryluk and Michiaki Kubo and Jong-Young Lee and Liming Liang and Lifton, {Richard P} and Baoshan Ma and McCarroll, {Steven A} and McKnight, {Amy J} and Min, {Josine L} and Moffatt, {Miriam F} and Montgomery, {Grant W} and Murabito, {Joanne M} and George Nicholson and Nyholt, {Dale R} and Yukinori Okada and Perry, {John R B} and Rajkumar Dorajoo and Eva Reinmaa and Salem, {Rany M} and Niina Sandholm and Scott, {Robert A} and Lisette Stolk and Atsushi Takahashi and Toshihiro Tanaka and {Van't Hooft}, {Ferdinand M} and Vinkhuyzen, {Anna A E} and Harm-Jan Westra and Wei Zheng and Zondervan, {Krina T} and Heath, {Andrew C} and Dominique Arveiler and Bakker, {Stephan J L} and John Beilby and Bergman, {Richard N} and John Blangero and Pascal Bovet and Harry Campbell and Caulfield, {Mark J} and Giancarlo Cesana and Aravinda Chakravarti and Chasman, {Daniel I} and Chines, {Peter S} and Collins, {Francis S} and Crawford, {Dana C} and Cupples, {L Adrienne} and Daniele Cusi and John Danesh and {de Faire}, Ulf and {den Ruijter}, {Hester M} and Dominiczak, {Anna F} and Raimund Erbel and Jeanette Erdmann and Eriksson, {Johan G} and Martin Farrall and Felix, {Stephan B} and Ele Ferrannini and Jean Ferri{\`e}res and Ian Ford and Forouhi, {Nita G} and Terrence Forrester and Franco, {Oscar H} and Gansevoort, {Ron T} and Gejman, {Pablo V} and Christian Gieger and Omri Gottesman and Vilmundur Gudnason and Ulf Gyllensten and Hall, {Alistair S} and Harris, {Tamara B} and Hattersley, {Andrew T} and Hicks, {Andrew A} and Hindorff, {Lucia A} and Hingorani, {Aroon D} and Albert Hofman and Georg Homuth and Hovingh, {G Kees} and Humphries, {Steve E} and Hunt, {Steven C} and Elina Hypp{\"o}nen and Thomas Illig and Jacobs, {Kevin B} and Marjo-Riitta Jarvelin and Karl-Heinz J{\"o}ckel and Berit Johansen and Pekka Jousilahti and Jukema, {J Wouter} and Jula, {Antti M} and Jaakko Kaprio and Kastelein, {John J P} and Keinanen-Kiukaanniemi, {Sirkka M} and Kiemeney, {Lambertus A} and Paul Knekt and Kooner, {Jaspal S} and Charles Kooperberg and Peter Kovacs and Kraja, {Aldi T} and Meena Kumari and Johanna Kuusisto and Lakka, {Timo A} and Claudia Langenberg and {Le Marchand}, Loic and Terho Lehtim{\"a}ki and Valeriya Lyssenko and Satu M{\"a}nnist{\"o} and Andr{\'e} Marette and Matise, {Tara C} and McKenzie, {Colin A} and Barbara McKnight and Moll, {Frans L} and Morris, {Andrew D} and Morris, {Andrew P} and Murray, {Jeffrey C} and Mari Nelis and Claes Ohlsson and Oldehinkel, {Albertine J} and Ong, {Ken K} and Madden, {Pamela A F} and Gerard Pasterkamp and Peden, {John F} and Annette Peters and Postma, {Dirkje S} and Pramstaller, {Peter P} and Price, {Jackie F} and Lu Qi and Raitakari, {Olli T} and Tuomo Rankinen and Rao, {D C} and Rice, {Treva K} and Ridker, {Paul M} and Rioux, {John D} and Ritchie, {Marylyn D} and Igor Rudan and Veikko Salomaa and Samani, {Nilesh J} and Jouko Saramies and Sarzynski, {Mark A} and Heribert Schunkert and Schwarz, {Peter E H} and Peter Sever and Shuldiner, {Alan R} and Juha Sinisalo and Stolk, {Ronald P} and Konstantin Strauch and Anke T{\"o}njes and David-Alexandre Tr{\'e}gou{\"e}t and Angelo Tremblay and Elena Tremoli and Jarmo Virtamo and Marie-Claude Vohl and Uwe V{\"o}lker and G{\'e}rard Waeber and Gonneke Willemsen and Witteman, {Jacqueline C} and Zillikens, {M Carola} and Adair, {Linda S} and Philippe Amouyel and Asselbergs, {Folkert W} and Assimes, {Themistocles L} and Murielle Bochud and Boehm, {Bernhard O} and Eric Boerwinkle and Bornstein, {Stefan R} and Bottinger, {Erwin P} and Claude Bouchard and St{\'e}phane Cauchi and Chambers, {John C} and Chanock, {Stephen J} and Cooper, {Richard S} and {de Bakker}, {Paul I W} and George Dedoussis and Luigi Ferrucci and Paul Franks and Philippe Froguel and Leif Groop and Haiman, {Christopher A} and Anders Hamsten and Jennie Hui and Hunter, {David J} and Kristian Hveem and Kaplan, {Robert C} and Mika Kivimaki and Diana Kuh and Markku Laakso and Yongmei Liu and Martin, {Nicholas G} and Winfried M{\"a}rz and Mads Melbye and Andres Metspalu and Susanne Moebus and Munroe, {Patricia B} and Inger Nj{\o}lstad and Oostra, {Ben A} and Palmer, {Colin N A} and Pedersen, {Nancy L} and Markus Perola and Louis P{\'e}russe and Ulrike Peters and Chris Power and Thomas Quertermous and Rainer Rauramaa and Fernando Rivadeneira and Saaristo, {Timo E} and Danish Saleheen and Naveed Sattar and Schadt, {Eric E} and David Schlessinger and Slagboom, {P Eline} and Harold Snieder and Spector, {Tim D} and Unnur Thorsteinsdottir and Michael Stumvoll and Jaakko Tuomilehto and Uitterlinden, {Andr{\'e} G} and Matti Uusitupa and {van der Harst}, Pim and Mark Walker and Henri Wallaschofski and Wareham, {Nicholas J} and Hugh Watkins and Weir, {David R} and H-Erich Wichmann and Wilson, {James F} and Pieter Zanen and Borecki, {Ingrid B} and Panos Deloukas and Fox, {Caroline S} and Heid, {Iris M} and O'Connell, {Jeffrey R} and Strachan, {David P} and Kari Stefansson and {van Duijn}, {Cornelia M} and Abecasis, {Gon{\cc}alo R} and Lude Franke and Frayling, {Timothy M} and McCarthy, {Mark I} and Visscher, {Peter M} and Andr{\'e} Scherag and Willer, {Cristen J} and Michael Boehnke and Mohlke, {Karen L} and Lindgren, {Cecilia M} and Beckmann, {Jacques S} and In{\^e}s Barroso and North, {Kari E} and Erik Ingelsson and Hirschhorn, {Joel N} and Loos, {Ruth J F} and Speliotes, {Elizabeth K}",
year = "2015",
doi = "10.1038/nature14177",
language = "English",
volume = "518",
pages = "197--U401",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7538",