Genetic studies of body mass index yield new insights for obesity biology.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Genetic studies of body mass index yield new insights for obesity biology. / Locke, Adam E; Kahali, Bratati; Berndt, Sonja I; Justice, Anne E; Pers, Tune H; Day, Felix R; Powell, Corey; Vedantam, Sailaja; Buchkovich, Martin L; Yang, Jian; Croteau-Chonka, Damien C; Esko, Tonu; Fall, Tove; Ferreira, Teresa; Gustafsson, Stefan; Kutalik, Zoltán; Luan, Jian'an; Mägi, Reedik; Randall, Joshua C; Winkler, Thomas W; Wood, Andrew R; Workalemahu, Tsegaselassie; Faul, Jessica D; Smith, Jennifer A; Hua Zhao, Jing; Zhao, Wei; Chen, Jin; Fehrmann, Rudolf; Hedman, Åsa K; Karjalainen, Juha; Schmidt, Ellen M; Absher, Devin; Amin, Najaf; Anderson, Denise; Beekman, Marian; Bolton, Jennifer L; Bragg-Gresham, Jennifer L; Buyske, Steven; Demirkan, Ayse; Deng, Guohong; Ehret, Georg B; Feenstra, Bjarke; Feitosa, Mary F; Fischer, Krista; Goel, Anuj; Gong, Jian; Jackson, Anne U; Kanoni, Stavroula; Kleber, Marcus E; Kristiansson, Kati; Lim, Unhee; Lotay, Vaneet; Mangino, Massimo; Mateo Leach, Irene; Medina-Gomez, Carolina; Medland, Sarah E; Nalls, Michael A; Palmer, Cameron D; Pasko, Dorota; Pechlivanis, Sonali; Peters, Marjolein J; Prokopenko, Inga; Shungin, Dmitry; Stančáková, Alena; Strawbridge, Rona J; Ju Sung, Yun; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W; van Setten, Jessica; Van Vliet-Ostaptchouk, Jana V; Wang, Zhaoming; Yengo, Loïc; Zhang, Weihua; Isaacs, Aaron; Albrecht, Eva; Ärnlöv, Johan; Arscott, Gillian M; Attwood, Antony P; Bandinelli, Stefania; Barrett, Amy; Bas, Isabelita N; Bellis, Claire; Bennett, Amanda J; Berne, Christian; Blagieva, Roza; Blüher, Matthias; Böhringer, Stefan; Bonnycastle, Lori L; Böttcher, Yvonne; Boyd, Heather A; Bruinenberg, Marcel; Caspersen, Ida H; Ida Chen, Yii-Der; Clarke, Robert; Daw, E Warwick; de Craen, Anton J M; Delgado, Graciela; Dimitriou, Maria; Doney, Alex S F; Eklund, Niina; Estrada, Karol; Eury, Elodie; Folkersen, Lasse; Fraser, Ross M; Garcia, Melissa E; Geller, Frank; Giedraitis, Vilmantas; Gigante, Bruna; Go, Alan S; Golay, Alain; Goodall, Alison H; Gordon, Scott D; Gorski, Mathias; Grabe, Hans-Jörgen; Grallert, Harald; Grammer, Tanja B; Gräßler, Jürgen; Grönberg, Henrik; Groves, Christopher J; Gusto, Gaëlle; Haessler, Jeffrey; Hall, Per; Haller, Toomas; Hallmans, Goran; Hartman, Catharina A; Hassinen, Maija; Hayward, Caroline; Heard-Costa, Nancy L; Helmer, Quinta; Hengstenberg, Christian; Holmen, Oddgeir; Hottenga, Jouke-Jan; James, Alan L; Jeff, Janina M; Johansson, Åsa; Jolley, Jennifer; Juliusdottir, Thorhildur; Kinnunen, Leena; Koenig, Wolfgang; Koskenvuo, Markku; Kratzer, Wolfgang; Laitinen, Jaana; Lamina, Claudia; Leander, Karin; Lee, Nanette R; Lichtner, Peter; Lind, Lars; Lindström, Jaana; Sin Lo, Ken; Lobbens, Stéphane; Lorbeer, Roberto; Lu, Yingchang; Mach, François; Magnusson, Patrik K E; Mahajan, Anubha; McArdle, Wendy L; McLachlan, Stela; Menni, Cristina; Merger, Sigrun; Mihailov, Evelin; Milani, Lili; Moayyeri, Alireza; Monda, Keri L; Morken, Mario A; Mulas, Antonella; Müller, Gabriele; Müller-Nurasyid, Martina; Musk, Arthur W; Nagaraja, Ramaiah; Nöthen, Markus M; Nolte, Ilja M; Pilz, Stefan; Rayner, Nigel W; Renström, Frida; Rettig, Rainer; Ried, Janina S; Ripke, Stephan; Robertson, Neil R; Rose, Lynda M; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Schumacher, Fredrick R; Scott, William R; Seufferlein, Thomas; Shi, Jianxin; Vernon Smith, Albert; Smolonska, Joanna; Stanton, Alice V; Steinthorsdottir, Valgerdur; Stirrups, Kathleen; Stringham, Heather M; Sundström, Johan; Swertz, Morris A; Swift, Amy J; Syvänen, Ann-Christine; Tan, Sian-Tsung; Tayo, Bamidele O; Thorand, Barbara; Thorleifsson, Gudmar; Tyrer, Jonathan P; Uh, Hae-Won; Vandenput, Liesbeth; Verhulst, Frank C; Vermeulen, Sita H; Verweij, Niek; Vonk, Judith M; Waite, Lindsay L; Warren, Helen R; Waterworth, Dawn; Weedon, Michael N; Wilkens, Lynne R; Willenborg, Christina; Wilsgaard, Tom; Wojczynski, Mary K; Wong, Andrew; Wright, Alan F; Zhang, Qunyuan; Brennan, Eoin P; Choi, Murim; Dastani, Zari; Drong, Alexander W; Eriksson, Per; Franco-Cereceda, Anders; Gådin, Jesper R; Gharavi, Ali G; Goddard, Michael E; Handsaker, Robert E; Huang, Jinyan; Karpe, Fredrik; Kathiresan, Sekar; Keildson, Sarah; Kiryluk, Krzysztof; Kubo, Michiaki; Lee, Jong-Young; Liang, Liming; Lifton, Richard P; Ma, Baoshan; McCarroll, Steven A; McKnight, Amy J; Min, Josine L; Moffatt, Miriam F; Montgomery, Grant W; Murabito, Joanne M; Nicholson, George; Nyholt, Dale R; Okada, Yukinori; Perry, John R B; Dorajoo, Rajkumar; Reinmaa, Eva; Salem, Rany M; Sandholm, Niina; Scott, Robert A; Stolk, Lisette; Takahashi, Atsushi; Tanaka, Toshihiro; Van't Hooft, Ferdinand M; Vinkhuyzen, Anna A E; Westra, Harm-Jan; Zheng, Wei; Zondervan, Krina T; Heath, Andrew C; Arveiler, Dominique; Bakker, Stephan J L; Beilby, John; Bergman, Richard N; Blangero, John; Bovet, Pascal; Campbell, Harry; Caulfield, Mark J; Cesana, Giancarlo; Chakravarti, Aravinda; Chasman, Daniel I; Chines, Peter S; Collins, Francis S; Crawford, Dana C; Cupples, L Adrienne; Cusi, Daniele; Danesh, John; de Faire, Ulf; den Ruijter, Hester M; Dominiczak, Anna F; Erbel, Raimund; Erdmann, Jeanette; Eriksson, Johan G; Farrall, Martin; Felix, Stephan B; Ferrannini, Ele; Ferrières, Jean; Ford, Ian; Forouhi, Nita G; Forrester, Terrence; Franco, Oscar H; Gansevoort, Ron T; Gejman, Pablo V; Gieger, Christian; Gottesman, Omri; Gudnason, Vilmundur; Gyllensten, Ulf; Hall, Alistair S; Harris, Tamara B; Hattersley, Andrew T; Hicks, Andrew A; Hindorff, Lucia A; Hingorani, Aroon D; Hofman, Albert; Homuth, Georg; Hovingh, G Kees; Humphries, Steve E; Hunt, Steven C; Hyppönen, Elina; Illig, Thomas; Jacobs, Kevin B; Jarvelin, Marjo-Riitta; Jöckel, Karl-Heinz; Johansen, Berit; Jousilahti, Pekka; Jukema, J Wouter; Jula, Antti M; Kaprio, Jaakko; Kastelein, John J P; Keinanen-Kiukaanniemi, Sirkka M; Kiemeney, Lambertus A; Knekt, Paul; Kooner, Jaspal S; Kooperberg, Charles; Kovacs, Peter; Kraja, Aldi T; Kumari, Meena; Kuusisto, Johanna; Lakka, Timo A; Langenberg, Claudia; Le Marchand, Loic; Lehtimäki, Terho; Lyssenko, Valeriya; Männistö, Satu; Marette, André; Matise, Tara C; McKenzie, Colin A; McKnight, Barbara; Moll, Frans L; Morris, Andrew D; Morris, Andrew P; Murray, Jeffrey C; Nelis, Mari; Ohlsson, Claes; Oldehinkel, Albertine J; Ong, Ken K; Madden, Pamela A F; Pasterkamp, Gerard; Peden, John F; Peters, Annette; Postma, Dirkje S; Pramstaller, Peter P; Price, Jackie F; Qi, Lu; Raitakari, Olli T; Rankinen, Tuomo; Rao, D C; Rice, Treva K; Ridker, Paul M; Rioux, John D; Ritchie, Marylyn D; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J; Saramies, Jouko; Sarzynski, Mark A; Schunkert, Heribert; Schwarz, Peter E H; Sever, Peter; Shuldiner, Alan R; Sinisalo, Juha; Stolk, Ronald P; Strauch, Konstantin; Tönjes, Anke; Trégouët, David-Alexandre; Tremblay, Angelo; Tremoli, Elena; Virtamo, Jarmo; Vohl, Marie-Claude; Völker, Uwe; Waeber, Gérard; Willemsen, Gonneke; Witteman, Jacqueline C; Zillikens, M Carola; Adair, Linda S; Amouyel, Philippe; Asselbergs, Folkert W; Assimes, Themistocles L; Bochud, Murielle; Boehm, Bernhard O; Boerwinkle, Eric; Bornstein, Stefan R; Bottinger, Erwin P; Bouchard, Claude; Cauchi, Stéphane; Chambers, John C; Chanock, Stephen J; Cooper, Richard S; de Bakker, Paul I W; Dedoussis, George; Ferrucci, Luigi; Franks, Paul; Froguel, Philippe; Groop, Leif; Haiman, Christopher A; Hamsten, Anders; Hui, Jennie; Hunter, David J; Hveem, Kristian; Kaplan, Robert C; Kivimaki, Mika; Kuh, Diana; Laakso, Markku; Liu, Yongmei; Martin, Nicholas G; März, Winfried; Melbye, Mads; Metspalu, Andres; Moebus, Susanne; Munroe, Patricia B; Njølstad, Inger; Oostra, Ben A; Palmer, Colin N A; Pedersen, Nancy L; Perola, Markus; Pérusse, Louis; Peters, Ulrike; Power, Chris; Quertermous, Thomas; Rauramaa, Rainer; Rivadeneira, Fernando; Saaristo, Timo E; Saleheen, Danish; Sattar, Naveed; Schadt, Eric E; Schlessinger, David; Slagboom, P Eline; Snieder, Harold; Spector, Tim D; Thorsteinsdottir, Unnur; Stumvoll, Michael; Tuomilehto, Jaakko; Uitterlinden, André G; Uusitupa, Matti; van der Harst, Pim; Walker, Mark; Wallaschofski, Henri; Wareham, Nicholas J; Watkins, Hugh; Weir, David R; Wichmann, H-Erich; Wilson, James F; Zanen, Pieter; Borecki, Ingrid B; Deloukas, Panos; Fox, Caroline S; Heid, Iris M; O'Connell, Jeffrey R; Strachan, David P; Stefansson, Kari; van Duijn, Cornelia M; Abecasis, Gonçalo R; Franke, Lude; Frayling, Timothy M; McCarthy, Mark I; Visscher, Peter M; Scherag, André; Willer, Cristen J; Boehnke, Michael; Mohlke, Karen L; Lindgren, Cecilia M; Beckmann, Jacques S; Barroso, Inês; North, Kari E; Ingelsson, Erik; Hirschhorn, Joel N; Loos, Ruth J F; Speliotes, Elizabeth K.

I: Nature, Vol. 518, Nr. 7538, 2015, s. 197-U401.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Locke, AE, Kahali, B, Berndt, SI, Justice, AE, Pers, TH, Day, FR, Powell, C, Vedantam, S, Buchkovich, ML, Yang, J, Croteau-Chonka, DC, Esko, T, Fall, T, Ferreira, T, Gustafsson, S, Kutalik, Z, Luan, J, Mägi, R, Randall, JC, Winkler, TW, Wood, AR, Workalemahu, T, Faul, JD, Smith, JA, Hua Zhao, J, Zhao, W, Chen, J, Fehrmann, R, Hedman, ÅK, Karjalainen, J, Schmidt, EM, Absher, D, Amin, N, Anderson, D, Beekman, M, Bolton, JL, Bragg-Gresham, JL, Buyske, S, Demirkan, A, Deng, G, Ehret, GB, Feenstra, B, Feitosa, MF, Fischer, K, Goel, A, Gong, J, Jackson, AU, Kanoni, S, Kleber, ME, Kristiansson, K, Lim, U, Lotay, V, Mangino, M, Mateo Leach, I, Medina-Gomez, C, Medland, SE, Nalls, MA, Palmer, CD, Pasko, D, Pechlivanis, S, Peters, MJ, Prokopenko, I, Shungin, D, Stančáková, A, Strawbridge, RJ, Ju Sung, Y, Tanaka, T, Teumer, A, Trompet, S, van der Laan, SW, van Setten, J, Van Vliet-Ostaptchouk, JV, Wang, Z, Yengo, L, Zhang, W, Isaacs, A, Albrecht, E, Ärnlöv, J, Arscott, GM, Attwood, AP, Bandinelli, S, Barrett, A, Bas, IN, Bellis, C, Bennett, AJ, Berne, C, Blagieva, R, Blüher, M, Böhringer, S, Bonnycastle, LL, Böttcher, Y, Boyd, HA, Bruinenberg, M, Caspersen, IH, Ida Chen, Y-D, Clarke, R, Daw, EW, de Craen, AJM, Delgado, G, Dimitriou, M, Doney, ASF, Eklund, N, Estrada, K, Eury, E, Folkersen, L, Fraser, RM, Garcia, ME, Geller, F, Giedraitis, V, Gigante, B, Go, AS, Golay, A, Goodall, AH, Gordon, SD, Gorski, M, Grabe, H-J, Grallert, H, Grammer, TB, Gräßler, J, Grönberg, H, Groves, CJ, Gusto, G, Haessler, J, Hall, P, Haller, T, Hallmans, G, Hartman, CA, Hassinen, M, Hayward, C, Heard-Costa, NL, Helmer, Q, Hengstenberg, C, Holmen, O, Hottenga, J-J, James, AL, Jeff, JM, Johansson, Å, Jolley, J, Juliusdottir, T, Kinnunen, L, Koenig, W, Koskenvuo, M, Kratzer, W, Laitinen, J, Lamina, C, Leander, K, Lee, NR, Lichtner, P, Lind, L, Lindström, J, Sin Lo, K, Lobbens, S, Lorbeer, R, Lu, Y, Mach, F, Magnusson, PKE, Mahajan, A, McArdle, WL, McLachlan, S, Menni, C, Merger, S, Mihailov, E, Milani, L, Moayyeri, A, Monda, KL, Morken, MA, Mulas, A, Müller, G, Müller-Nurasyid, M, Musk, AW, Nagaraja, R, Nöthen, MM, Nolte, IM, Pilz, S, Rayner, NW, Renström, F, Rettig, R, Ried, JS, Ripke, S, Robertson, NR, Rose, LM, Sanna, S, Scharnagl, H, Scholtens, S, Schumacher, FR, Scott, WR, Seufferlein, T, Shi, J, Vernon Smith, A, Smolonska, J, Stanton, AV, Steinthorsdottir, V, Stirrups, K, Stringham, HM, Sundström, J, Swertz, MA, Swift, AJ, Syvänen, A-C, Tan, S-T, Tayo, BO, Thorand, B, Thorleifsson, G, Tyrer, JP, Uh, H-W, Vandenput, L, Verhulst, FC, Vermeulen, SH, Verweij, N, Vonk, JM, Waite, LL, Warren, HR, Waterworth, D, Weedon, MN, Wilkens, LR, Willenborg, C, Wilsgaard, T, Wojczynski, MK, Wong, A, Wright, AF, Zhang, Q, Brennan, EP, Choi, M, Dastani, Z, Drong, AW, Eriksson, P, Franco-Cereceda, A, Gådin, JR, Gharavi, AG, Goddard, ME, Handsaker, RE, Huang, J, Karpe, F, Kathiresan, S, Keildson, S, Kiryluk, K, Kubo, M, Lee, J-Y, Liang, L, Lifton, RP, Ma, B, McCarroll, SA, McKnight, AJ, Min, JL, Moffatt, MF, Montgomery, GW, Murabito, JM, Nicholson, G, Nyholt, DR, Okada, Y, Perry, JRB, Dorajoo, R, Reinmaa, E, Salem, RM, Sandholm, N, Scott, RA, Stolk, L, Takahashi, A, Tanaka, T, Van't Hooft, FM, Vinkhuyzen, AAE, Westra, H-J, Zheng, W, Zondervan, KT, Heath, AC, Arveiler, D, Bakker, SJL, Beilby, J, Bergman, RN, Blangero, J, Bovet, P, Campbell, H, Caulfield, MJ, Cesana, G, Chakravarti, A, Chasman, DI, Chines, PS, Collins, FS, Crawford, DC, Cupples, LA, Cusi, D, Danesh, J, de Faire, U, den Ruijter, HM, Dominiczak, AF, Erbel, R, Erdmann, J, Eriksson, JG, Farrall, M, Felix, SB, Ferrannini, E, Ferrières, J, Ford, I, Forouhi, NG, Forrester, T, Franco, OH, Gansevoort, RT, Gejman, PV, Gieger, C, Gottesman, O, Gudnason, V, Gyllensten, U, Hall, AS, Harris, TB, Hattersley, AT, Hicks, AA, Hindorff, LA, Hingorani, AD, Hofman, A, Homuth, G, Hovingh, GK, Humphries, SE, Hunt, SC, Hyppönen, E, Illig, T, Jacobs, KB, Jarvelin, M-R, Jöckel, K-H, Johansen, B, Jousilahti, P, Jukema, JW, Jula, AM, Kaprio, J, Kastelein, JJP, Keinanen-Kiukaanniemi, SM, Kiemeney, LA, Knekt, P, Kooner, JS, Kooperberg, C, Kovacs, P, Kraja, AT, Kumari, M, Kuusisto, J, Lakka, TA, Langenberg, C, Le Marchand, L, Lehtimäki, T, Lyssenko, V, Männistö, S, Marette, A, Matise, TC, McKenzie, CA, McKnight, B, Moll, FL, Morris, AD, Morris, AP, Murray, JC, Nelis, M, Ohlsson, C, Oldehinkel, AJ, Ong, KK, Madden, PAF, Pasterkamp, G, Peden, JF, Peters, A, Postma, DS, Pramstaller, PP, Price, JF, Qi, L, Raitakari, OT, Rankinen, T, Rao, DC, Rice, TK, Ridker, PM, Rioux, JD, Ritchie, MD, Rudan, I, Salomaa, V, Samani, NJ, Saramies, J, Sarzynski, MA, Schunkert, H, Schwarz, PEH, Sever, P, Shuldiner, AR, Sinisalo, J, Stolk, RP, Strauch, K, Tönjes, A, Trégouët, D-A, Tremblay, A, Tremoli, E, Virtamo, J, Vohl, M-C, Völker, U, Waeber, G, Willemsen, G, Witteman, JC, Zillikens, MC, Adair, LS, Amouyel, P, Asselbergs, FW, Assimes, TL, Bochud, M, Boehm, BO, Boerwinkle, E, Bornstein, SR, Bottinger, EP, Bouchard, C, Cauchi, S, Chambers, JC, Chanock, SJ, Cooper, RS, de Bakker, PIW, Dedoussis, G, Ferrucci, L, Franks, P, Froguel, P, Groop, L, Haiman, CA, Hamsten, A, Hui, J, Hunter, DJ, Hveem, K, Kaplan, RC, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, Martin, NG, März, W, Melbye, M, Metspalu, A, Moebus, S, Munroe, PB, Njølstad, I, Oostra, BA, Palmer, CNA, Pedersen, NL, Perola, M, Pérusse, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, TE, Saleheen, D, Sattar, N, Schadt, EE, Schlessinger, D, Slagboom, PE, Snieder, H, Spector, TD, Thorsteinsdottir, U, Stumvoll, M, Tuomilehto, J, Uitterlinden, AG, Uusitupa, M, van der Harst, P, Walker, M, Wallaschofski, H, Wareham, NJ, Watkins, H, Weir, DR, Wichmann, H-E, Wilson, JF, Zanen, P, Borecki, IB, Deloukas, P, Fox, CS, Heid, IM, O'Connell, JR, Strachan, DP, Stefansson, K, van Duijn, CM, Abecasis, GR, Franke, L, Frayling, TM, McCarthy, MI, Visscher, PM, Scherag, A, Willer, CJ, Boehnke, M, Mohlke, KL, Lindgren, CM, Beckmann, JS, Barroso, I, North, KE, Ingelsson, E, Hirschhorn, JN, Loos, RJF & Speliotes, EK 2015, 'Genetic studies of body mass index yield new insights for obesity biology.', Nature, vol. 518, nr. 7538, s. 197-U401. https://doi.org/10.1038/nature14177

APA

Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., ... Speliotes, E. K. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-U401. https://doi.org/10.1038/nature14177

CBE

Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, Kutalik Z, Luan J, Mägi R, Randall JC, Winkler TW, Wood AR, Workalemahu T, Faul JD, Smith JA, Hua Zhao J, Zhao W, Chen J, Fehrmann R, Hedman ÅK, Karjalainen J, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bolton JL, Bragg-Gresham JL, Buyske S, Demirkan A, Deng G, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Goel A, Gong J, Jackson AU, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Mangino M, Mateo Leach I, Medina-Gomez C, Medland SE, Nalls MA, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Shungin D, Stančáková A, Strawbridge RJ, Ju Sung Y, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Isaacs A, Albrecht E, Ärnlöv J, Arscott GM, Attwood AP, Bandinelli S, Barrett A, Bas IN, Bellis C, Bennett AJ, Berne C, Blagieva R, Blüher M, Böhringer S, Bonnycastle LL, Böttcher Y, Boyd HA, Bruinenberg M, Caspersen IH, Ida Chen Y-D, Clarke R, Daw EW, de Craen AJM, Delgado G, Dimitriou M, Doney ASF, Eklund N, Estrada K, Eury E, Folkersen L, Fraser RM, Garcia ME, Geller F, Giedraitis V, Gigante B, Go AS, Golay A, Goodall AH, Gordon SD, Gorski M, Grabe H-J, Grallert H, Grammer TB, Gräßler J, Grönberg H, Groves CJ, Gusto G, Haessler J, Hall P, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hengstenberg C, Holmen O, Hottenga J-J, James AL, Jeff JM, Johansson Å, Jolley J, Juliusdottir T, Kinnunen L, Koenig W, Koskenvuo M, Kratzer W, Laitinen J, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindström J, Sin Lo K, Lobbens S, Lorbeer R, Lu Y, Mach F, Magnusson PKE, Mahajan A, McArdle WL, McLachlan S, Menni C, Merger S, Mihailov E, Milani L, Moayyeri A, Monda KL, Morken MA, Mulas A, Müller G, Müller-Nurasyid M, Musk AW, Nagaraja R, Nöthen MM, Nolte IM, Pilz S, Rayner NW, Renström F, Rettig R, Ried JS, Ripke S, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Scott WR, Seufferlein T, Shi J, Vernon Smith A, Smolonska J, Stanton AV, Steinthorsdottir V, Stirrups K, Stringham HM, Sundström J, Swertz MA, Swift AJ, Syvänen A-C, Tan S-T, Tayo BO, Thorand B, Thorleifsson G, Tyrer JP, Uh H-W, Vandenput L, Verhulst FC, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Warren HR, Waterworth D, Weedon MN, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, Brennan EP, Choi M, Dastani Z, Drong AW, Eriksson P, Franco-Cereceda A, Gådin JR, Gharavi AG, Goddard ME, Handsaker RE, Huang J, Karpe F, Kathiresan S, Keildson S, Kiryluk K, Kubo M, Lee J-Y, Liang L, Lifton RP, Ma B, McCarroll SA, McKnight AJ, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Okada Y, Perry JRB, Dorajoo R, Reinmaa E, Salem RM, Sandholm N, Scott RA, Stolk L, Takahashi A, Tanaka T, Van't Hooft FM, Vinkhuyzen AAE, Westra H-J, Zheng W, Zondervan KT, Heath AC, Arveiler D, Bakker SJL, Beilby J, Bergman RN, Blangero J, Bovet P, Campbell H, Caulfield MJ, Cesana G, Chakravarti A, Chasman DI, Chines PS, Collins FS, Crawford DC, Cupples LA, Cusi D, Danesh J, de Faire U, den Ruijter HM, Dominiczak AF, Erbel R, Erdmann J, Eriksson JG, Farrall M, Felix SB, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gejman PV, Gieger C, Gottesman O, Gudnason V, Gyllensten U, Hall AS, Harris TB, Hattersley AT, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Homuth G, Hovingh GK, Humphries SE, Hunt SC, Hyppönen E, Illig T, Jacobs KB, Jarvelin M-R, Jöckel K-H, Johansen B, Jousilahti P, Jukema JW, Jula AM, Kaprio J, Kastelein JJP, Keinanen-Kiukaanniemi SM, Kiemeney LA, Knekt P, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie CA, McKnight B, Moll FL, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Madden PAF, Pasterkamp G, Peden JF, Peters A, Postma DS, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Rioux JD, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schunkert H, Schwarz PEH, Sever P, Shuldiner AR, Sinisalo J, Stolk RP, Strauch K, Tönjes A, Trégouët D-A, Tremblay A, Tremoli E, Virtamo J, Vohl M-C, Völker U, Waeber G, Willemsen G, Witteman JC, Zillikens MC, Adair LS, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bornstein SR, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PIW, Dedoussis G, Ferrucci L, Franks P, Froguel P, Groop L, Haiman CA, Hamsten A, Hui J, Hunter DJ, Hveem K, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Metspalu A, Moebus S, Munroe PB, Njølstad I, Oostra BA, Palmer CNA, Pedersen NL, Perola M, Pérusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sattar N, Schadt EE, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Weir DR, Wichmann H-E, Wilson JF, Zanen P, Borecki IB, Deloukas P, Fox CS, Heid IM, O'Connell JR, Strachan DP, Stefansson K, van Duijn CM, Abecasis GR, Franke L, Frayling TM, McCarthy MI, Visscher PM, Scherag A, Willer CJ, Boehnke M, Mohlke KL, Lindgren CM, Beckmann JS, Barroso I, North KE, Ingelsson E, Hirschhorn JN, Loos RJF, Speliotes EK. 2015. Genetic studies of body mass index yield new insights for obesity biology. Nature. 518(7538):197-U401. https://doi.org/10.1038/nature14177

MLA

Vancouver

Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518(7538):197-U401. https://doi.org/10.1038/nature14177

Author

Locke, Adam E ; Kahali, Bratati ; Berndt, Sonja I ; Justice, Anne E ; Pers, Tune H ; Day, Felix R ; Powell, Corey ; Vedantam, Sailaja ; Buchkovich, Martin L ; Yang, Jian ; Croteau-Chonka, Damien C ; Esko, Tonu ; Fall, Tove ; Ferreira, Teresa ; Gustafsson, Stefan ; Kutalik, Zoltán ; Luan, Jian'an ; Mägi, Reedik ; Randall, Joshua C ; Winkler, Thomas W ; Wood, Andrew R ; Workalemahu, Tsegaselassie ; Faul, Jessica D ; Smith, Jennifer A ; Hua Zhao, Jing ; Zhao, Wei ; Chen, Jin ; Fehrmann, Rudolf ; Hedman, Åsa K ; Karjalainen, Juha ; Schmidt, Ellen M ; Absher, Devin ; Amin, Najaf ; Anderson, Denise ; Beekman, Marian ; Bolton, Jennifer L ; Bragg-Gresham, Jennifer L ; Buyske, Steven ; Demirkan, Ayse ; Deng, Guohong ; Ehret, Georg B ; Feenstra, Bjarke ; Feitosa, Mary F ; Fischer, Krista ; Goel, Anuj ; Gong, Jian ; Jackson, Anne U ; Kanoni, Stavroula ; Kleber, Marcus E ; Kristiansson, Kati ; Lim, Unhee ; Lotay, Vaneet ; Mangino, Massimo ; Mateo Leach, Irene ; Medina-Gomez, Carolina ; Medland, Sarah E ; Nalls, Michael A ; Palmer, Cameron D ; Pasko, Dorota ; Pechlivanis, Sonali ; Peters, Marjolein J ; Prokopenko, Inga ; Shungin, Dmitry ; Stančáková, Alena ; Strawbridge, Rona J ; Ju Sung, Yun ; Tanaka, Toshiko ; Teumer, Alexander ; Trompet, Stella ; van der Laan, Sander W ; van Setten, Jessica ; Van Vliet-Ostaptchouk, Jana V ; Wang, Zhaoming ; Yengo, Loïc ; Zhang, Weihua ; Isaacs, Aaron ; Albrecht, Eva ; Ärnlöv, Johan ; Arscott, Gillian M ; Attwood, Antony P ; Bandinelli, Stefania ; Barrett, Amy ; Bas, Isabelita N ; Bellis, Claire ; Bennett, Amanda J ; Berne, Christian ; Blagieva, Roza ; Blüher, Matthias ; Böhringer, Stefan ; Bonnycastle, Lori L ; Böttcher, Yvonne ; Boyd, Heather A ; Bruinenberg, Marcel ; Caspersen, Ida H ; Ida Chen, Yii-Der ; Clarke, Robert ; Daw, E Warwick ; de Craen, Anton J M ; Delgado, Graciela ; Dimitriou, Maria ; Doney, Alex S F ; Eklund, Niina ; Estrada, Karol ; Eury, Elodie ; Folkersen, Lasse ; Fraser, Ross M ; Garcia, Melissa E ; Geller, Frank ; Giedraitis, Vilmantas ; Gigante, Bruna ; Go, Alan S ; Golay, Alain ; Goodall, Alison H ; Gordon, Scott D ; Gorski, Mathias ; Grabe, Hans-Jörgen ; Grallert, Harald ; Grammer, Tanja B ; Gräßler, Jürgen ; Grönberg, Henrik ; Groves, Christopher J ; Gusto, Gaëlle ; Haessler, Jeffrey ; Hall, Per ; Haller, Toomas ; Hallmans, Goran ; Hartman, Catharina A ; Hassinen, Maija ; Hayward, Caroline ; Heard-Costa, Nancy L ; Helmer, Quinta ; Hengstenberg, Christian ; Holmen, Oddgeir ; Hottenga, Jouke-Jan ; James, Alan L ; Jeff, Janina M ; Johansson, Åsa ; Jolley, Jennifer ; Juliusdottir, Thorhildur ; Kinnunen, Leena ; Koenig, Wolfgang ; Koskenvuo, Markku ; Kratzer, Wolfgang ; Laitinen, Jaana ; Lamina, Claudia ; Leander, Karin ; Lee, Nanette R ; Lichtner, Peter ; Lind, Lars ; Lindström, Jaana ; Sin Lo, Ken ; Lobbens, Stéphane ; Lorbeer, Roberto ; Lu, Yingchang ; Mach, François ; Magnusson, Patrik K E ; Mahajan, Anubha ; McArdle, Wendy L ; McLachlan, Stela ; Menni, Cristina ; Merger, Sigrun ; Mihailov, Evelin ; Milani, Lili ; Moayyeri, Alireza ; Monda, Keri L ; Morken, Mario A ; Mulas, Antonella ; Müller, Gabriele ; Müller-Nurasyid, Martina ; Musk, Arthur W ; Nagaraja, Ramaiah ; Nöthen, Markus M ; Nolte, Ilja M ; Pilz, Stefan ; Rayner, Nigel W ; Renström, Frida ; Rettig, Rainer ; Ried, Janina S ; Ripke, Stephan ; Robertson, Neil R ; Rose, Lynda M ; Sanna, Serena ; Scharnagl, Hubert ; Scholtens, Salome ; Schumacher, Fredrick R ; Scott, William R ; Seufferlein, Thomas ; Shi, Jianxin ; Vernon Smith, Albert ; Smolonska, Joanna ; Stanton, Alice V ; Steinthorsdottir, Valgerdur ; Stirrups, Kathleen ; Stringham, Heather M ; Sundström, Johan ; Swertz, Morris A ; Swift, Amy J ; Syvänen, Ann-Christine ; Tan, Sian-Tsung ; Tayo, Bamidele O ; Thorand, Barbara ; Thorleifsson, Gudmar ; Tyrer, Jonathan P ; Uh, Hae-Won ; Vandenput, Liesbeth ; Verhulst, Frank C ; Vermeulen, Sita H ; Verweij, Niek ; Vonk, Judith M ; Waite, Lindsay L ; Warren, Helen R ; Waterworth, Dawn ; Weedon, Michael N ; Wilkens, Lynne R ; Willenborg, Christina ; Wilsgaard, Tom ; Wojczynski, Mary K ; Wong, Andrew ; Wright, Alan F ; Zhang, Qunyuan ; Brennan, Eoin P ; Choi, Murim ; Dastani, Zari ; Drong, Alexander W ; Eriksson, Per ; Franco-Cereceda, Anders ; Gådin, Jesper R ; Gharavi, Ali G ; Goddard, Michael E ; Handsaker, Robert E ; Huang, Jinyan ; Karpe, Fredrik ; Kathiresan, Sekar ; Keildson, Sarah ; Kiryluk, Krzysztof ; Kubo, Michiaki ; Lee, Jong-Young ; Liang, Liming ; Lifton, Richard P ; Ma, Baoshan ; McCarroll, Steven A ; McKnight, Amy J ; Min, Josine L ; Moffatt, Miriam F ; Montgomery, Grant W ; Murabito, Joanne M ; Nicholson, George ; Nyholt, Dale R ; Okada, Yukinori ; Perry, John R B ; Dorajoo, Rajkumar ; Reinmaa, Eva ; Salem, Rany M ; Sandholm, Niina ; Scott, Robert A ; Stolk, Lisette ; Takahashi, Atsushi ; Tanaka, Toshihiro ; Van't Hooft, Ferdinand M ; Vinkhuyzen, Anna A E ; Westra, Harm-Jan ; Zheng, Wei ; Zondervan, Krina T ; Heath, Andrew C ; Arveiler, Dominique ; Bakker, Stephan J L ; Beilby, John ; Bergman, Richard N ; Blangero, John ; Bovet, Pascal ; Campbell, Harry ; Caulfield, Mark J ; Cesana, Giancarlo ; Chakravarti, Aravinda ; Chasman, Daniel I ; Chines, Peter S ; Collins, Francis S ; Crawford, Dana C ; Cupples, L Adrienne ; Cusi, Daniele ; Danesh, John ; de Faire, Ulf ; den Ruijter, Hester M ; Dominiczak, Anna F ; Erbel, Raimund ; Erdmann, Jeanette ; Eriksson, Johan G ; Farrall, Martin ; Felix, Stephan B ; Ferrannini, Ele ; Ferrières, Jean ; Ford, Ian ; Forouhi, Nita G ; Forrester, Terrence ; Franco, Oscar H ; Gansevoort, Ron T ; Gejman, Pablo V ; Gieger, Christian ; Gottesman, Omri ; Gudnason, Vilmundur ; Gyllensten, Ulf ; Hall, Alistair S ; Harris, Tamara B ; Hattersley, Andrew T ; Hicks, Andrew A ; Hindorff, Lucia A ; Hingorani, Aroon D ; Hofman, Albert ; Homuth, Georg ; Hovingh, G Kees ; Humphries, Steve E ; Hunt, Steven C ; Hyppönen, Elina ; Illig, Thomas ; Jacobs, Kevin B ; Jarvelin, Marjo-Riitta ; Jöckel, Karl-Heinz ; Johansen, Berit ; Jousilahti, Pekka ; Jukema, J Wouter ; Jula, Antti M ; Kaprio, Jaakko ; Kastelein, John J P ; Keinanen-Kiukaanniemi, Sirkka M ; Kiemeney, Lambertus A ; Knekt, Paul ; Kooner, Jaspal S ; Kooperberg, Charles ; Kovacs, Peter ; Kraja, Aldi T ; Kumari, Meena ; Kuusisto, Johanna ; Lakka, Timo A ; Langenberg, Claudia ; Le Marchand, Loic ; Lehtimäki, Terho ; Lyssenko, Valeriya ; Männistö, Satu ; Marette, André ; Matise, Tara C ; McKenzie, Colin A ; McKnight, Barbara ; Moll, Frans L ; Morris, Andrew D ; Morris, Andrew P ; Murray, Jeffrey C ; Nelis, Mari ; Ohlsson, Claes ; Oldehinkel, Albertine J ; Ong, Ken K ; Madden, Pamela A F ; Pasterkamp, Gerard ; Peden, John F ; Peters, Annette ; Postma, Dirkje S ; Pramstaller, Peter P ; Price, Jackie F ; Qi, Lu ; Raitakari, Olli T ; Rankinen, Tuomo ; Rao, D C ; Rice, Treva K ; Ridker, Paul M ; Rioux, John D ; Ritchie, Marylyn D ; Rudan, Igor ; Salomaa, Veikko ; Samani, Nilesh J ; Saramies, Jouko ; Sarzynski, Mark A ; Schunkert, Heribert ; Schwarz, Peter E H ; Sever, Peter ; Shuldiner, Alan R ; Sinisalo, Juha ; Stolk, Ronald P ; Strauch, Konstantin ; Tönjes, Anke ; Trégouët, David-Alexandre ; Tremblay, Angelo ; Tremoli, Elena ; Virtamo, Jarmo ; Vohl, Marie-Claude ; Völker, Uwe ; Waeber, Gérard ; Willemsen, Gonneke ; Witteman, Jacqueline C ; Zillikens, M Carola ; Adair, Linda S ; Amouyel, Philippe ; Asselbergs, Folkert W ; Assimes, Themistocles L ; Bochud, Murielle ; Boehm, Bernhard O ; Boerwinkle, Eric ; Bornstein, Stefan R ; Bottinger, Erwin P ; Bouchard, Claude ; Cauchi, Stéphane ; Chambers, John C ; Chanock, Stephen J ; Cooper, Richard S ; de Bakker, Paul I W ; Dedoussis, George ; Ferrucci, Luigi ; Franks, Paul ; Froguel, Philippe ; Groop, Leif ; Haiman, Christopher A ; Hamsten, Anders ; Hui, Jennie ; Hunter, David J ; Hveem, Kristian ; Kaplan, Robert C ; Kivimaki, Mika ; Kuh, Diana ; Laakso, Markku ; Liu, Yongmei ; Martin, Nicholas G ; März, Winfried ; Melbye, Mads ; Metspalu, Andres ; Moebus, Susanne ; Munroe, Patricia B ; Njølstad, Inger ; Oostra, Ben A ; Palmer, Colin N A ; Pedersen, Nancy L ; Perola, Markus ; Pérusse, Louis ; Peters, Ulrike ; Power, Chris ; Quertermous, Thomas ; Rauramaa, Rainer ; Rivadeneira, Fernando ; Saaristo, Timo E ; Saleheen, Danish ; Sattar, Naveed ; Schadt, Eric E ; Schlessinger, David ; Slagboom, P Eline ; Snieder, Harold ; Spector, Tim D ; Thorsteinsdottir, Unnur ; Stumvoll, Michael ; Tuomilehto, Jaakko ; Uitterlinden, André G ; Uusitupa, Matti ; van der Harst, Pim ; Walker, Mark ; Wallaschofski, Henri ; Wareham, Nicholas J ; Watkins, Hugh ; Weir, David R ; Wichmann, H-Erich ; Wilson, James F ; Zanen, Pieter ; Borecki, Ingrid B ; Deloukas, Panos ; Fox, Caroline S ; Heid, Iris M ; O'Connell, Jeffrey R ; Strachan, David P ; Stefansson, Kari ; van Duijn, Cornelia M ; Abecasis, Gonçalo R ; Franke, Lude ; Frayling, Timothy M ; McCarthy, Mark I ; Visscher, Peter M ; Scherag, André ; Willer, Cristen J ; Boehnke, Michael ; Mohlke, Karen L ; Lindgren, Cecilia M ; Beckmann, Jacques S ; Barroso, Inês ; North, Kari E ; Ingelsson, Erik ; Hirschhorn, Joel N ; Loos, Ruth J F ; Speliotes, Elizabeth K. / Genetic studies of body mass index yield new insights for obesity biology. I: Nature. 2015 ; Vol. 518, Nr. 7538. s. 197-U401.

RIS

TY - JOUR

T1 - Genetic studies of body mass index yield new insights for obesity biology.

AU - Locke, Adam E

AU - Kahali, Bratati

AU - Berndt, Sonja I

AU - Justice, Anne E

AU - Pers, Tune H

AU - Day, Felix R

AU - Powell, Corey

AU - Vedantam, Sailaja

AU - Buchkovich, Martin L

AU - Yang, Jian

AU - Croteau-Chonka, Damien C

AU - Esko, Tonu

AU - Fall, Tove

AU - Ferreira, Teresa

AU - Gustafsson, Stefan

AU - Kutalik, Zoltán

AU - Luan, Jian'an

AU - Mägi, Reedik

AU - Randall, Joshua C

AU - Winkler, Thomas W

AU - Wood, Andrew R

AU - Workalemahu, Tsegaselassie

AU - Faul, Jessica D

AU - Smith, Jennifer A

AU - Hua Zhao, Jing

AU - Zhao, Wei

AU - Chen, Jin

AU - Fehrmann, Rudolf

AU - Hedman, Åsa K

AU - Karjalainen, Juha

AU - Schmidt, Ellen M

AU - Absher, Devin

AU - Amin, Najaf

AU - Anderson, Denise

AU - Beekman, Marian

AU - Bolton, Jennifer L

AU - Bragg-Gresham, Jennifer L

AU - Buyske, Steven

AU - Demirkan, Ayse

AU - Deng, Guohong

AU - Ehret, Georg B

AU - Feenstra, Bjarke

AU - Feitosa, Mary F

AU - Fischer, Krista

AU - Goel, Anuj

AU - Gong, Jian

AU - Jackson, Anne U

AU - Kanoni, Stavroula

AU - Kleber, Marcus E

AU - Kristiansson, Kati

AU - Lim, Unhee

AU - Lotay, Vaneet

AU - Mangino, Massimo

AU - Mateo Leach, Irene

AU - Medina-Gomez, Carolina

AU - Medland, Sarah E

AU - Nalls, Michael A

AU - Palmer, Cameron D

AU - Pasko, Dorota

AU - Pechlivanis, Sonali

AU - Peters, Marjolein J

AU - Prokopenko, Inga

AU - Shungin, Dmitry

AU - Stančáková, Alena

AU - Strawbridge, Rona J

AU - Ju Sung, Yun

AU - Tanaka, Toshiko

AU - Teumer, Alexander

AU - Trompet, Stella

AU - van der Laan, Sander W

AU - van Setten, Jessica

AU - Van Vliet-Ostaptchouk, Jana V

AU - Wang, Zhaoming

AU - Yengo, Loïc

AU - Zhang, Weihua

AU - Isaacs, Aaron

AU - Albrecht, Eva

AU - Ärnlöv, Johan

AU - Arscott, Gillian M

AU - Attwood, Antony P

AU - Bandinelli, Stefania

AU - Barrett, Amy

AU - Bas, Isabelita N

AU - Bellis, Claire

AU - Bennett, Amanda J

AU - Berne, Christian

AU - Blagieva, Roza

AU - Blüher, Matthias

AU - Böhringer, Stefan

AU - Bonnycastle, Lori L

AU - Böttcher, Yvonne

AU - Boyd, Heather A

AU - Bruinenberg, Marcel

AU - Caspersen, Ida H

AU - Ida Chen, Yii-Der

AU - Clarke, Robert

AU - Daw, E Warwick

AU - de Craen, Anton J M

AU - Delgado, Graciela

AU - Dimitriou, Maria

AU - Doney, Alex S F

AU - Eklund, Niina

AU - Estrada, Karol

AU - Eury, Elodie

AU - Folkersen, Lasse

AU - Fraser, Ross M

AU - Garcia, Melissa E

AU - Geller, Frank

AU - Giedraitis, Vilmantas

AU - Gigante, Bruna

AU - Go, Alan S

AU - Golay, Alain

AU - Goodall, Alison H

AU - Gordon, Scott D

AU - Gorski, Mathias

AU - Grabe, Hans-Jörgen

AU - Grallert, Harald

AU - Grammer, Tanja B

AU - Gräßler, Jürgen

AU - Grönberg, Henrik

AU - Groves, Christopher J

AU - Gusto, Gaëlle

AU - Haessler, Jeffrey

AU - Hall, Per

AU - Haller, Toomas

AU - Hallmans, Goran

AU - Hartman, Catharina A

AU - Hassinen, Maija

AU - Hayward, Caroline

AU - Heard-Costa, Nancy L

AU - Helmer, Quinta

AU - Hengstenberg, Christian

AU - Holmen, Oddgeir

AU - Hottenga, Jouke-Jan

AU - James, Alan L

AU - Jeff, Janina M

AU - Johansson, Åsa

AU - Jolley, Jennifer

AU - Juliusdottir, Thorhildur

AU - Kinnunen, Leena

AU - Koenig, Wolfgang

AU - Koskenvuo, Markku

AU - Kratzer, Wolfgang

AU - Laitinen, Jaana

AU - Lamina, Claudia

AU - Leander, Karin

AU - Lee, Nanette R

AU - Lichtner, Peter

AU - Lind, Lars

AU - Lindström, Jaana

AU - Sin Lo, Ken

AU - Lobbens, Stéphane

AU - Lorbeer, Roberto

AU - Lu, Yingchang

AU - Mach, François

AU - Magnusson, Patrik K E

AU - Mahajan, Anubha

AU - McArdle, Wendy L

AU - McLachlan, Stela

AU - Menni, Cristina

AU - Merger, Sigrun

AU - Mihailov, Evelin

AU - Milani, Lili

AU - Moayyeri, Alireza

AU - Monda, Keri L

AU - Morken, Mario A

AU - Mulas, Antonella

AU - Müller, Gabriele

AU - Müller-Nurasyid, Martina

AU - Musk, Arthur W

AU - Nagaraja, Ramaiah

AU - Nöthen, Markus M

AU - Nolte, Ilja M

AU - Pilz, Stefan

AU - Rayner, Nigel W

AU - Renström, Frida

AU - Rettig, Rainer

AU - Ried, Janina S

AU - Ripke, Stephan

AU - Robertson, Neil R

AU - Rose, Lynda M

AU - Sanna, Serena

AU - Scharnagl, Hubert

AU - Scholtens, Salome

AU - Schumacher, Fredrick R

AU - Scott, William R

AU - Seufferlein, Thomas

AU - Shi, Jianxin

AU - Vernon Smith, Albert

AU - Smolonska, Joanna

AU - Stanton, Alice V

AU - Steinthorsdottir, Valgerdur

AU - Stirrups, Kathleen

AU - Stringham, Heather M

AU - Sundström, Johan

AU - Swertz, Morris A

AU - Swift, Amy J

AU - Syvänen, Ann-Christine

AU - Tan, Sian-Tsung

AU - Tayo, Bamidele O

AU - Thorand, Barbara

AU - Thorleifsson, Gudmar

AU - Tyrer, Jonathan P

AU - Uh, Hae-Won

AU - Vandenput, Liesbeth

AU - Verhulst, Frank C

AU - Vermeulen, Sita H

AU - Verweij, Niek

AU - Vonk, Judith M

AU - Waite, Lindsay L

AU - Warren, Helen R

AU - Waterworth, Dawn

AU - Weedon, Michael N

AU - Wilkens, Lynne R

AU - Willenborg, Christina

AU - Wilsgaard, Tom

AU - Wojczynski, Mary K

AU - Wong, Andrew

AU - Wright, Alan F

AU - Zhang, Qunyuan

AU - Brennan, Eoin P

AU - Choi, Murim

AU - Dastani, Zari

AU - Drong, Alexander W

AU - Eriksson, Per

AU - Franco-Cereceda, Anders

AU - Gådin, Jesper R

AU - Gharavi, Ali G

AU - Goddard, Michael E

AU - Handsaker, Robert E

AU - Huang, Jinyan

AU - Karpe, Fredrik

AU - Kathiresan, Sekar

AU - Keildson, Sarah

AU - Kiryluk, Krzysztof

AU - Kubo, Michiaki

AU - Lee, Jong-Young

AU - Liang, Liming

AU - Lifton, Richard P

AU - Ma, Baoshan

AU - McCarroll, Steven A

AU - McKnight, Amy J

AU - Min, Josine L

AU - Moffatt, Miriam F

AU - Montgomery, Grant W

AU - Murabito, Joanne M

AU - Nicholson, George

AU - Nyholt, Dale R

AU - Okada, Yukinori

AU - Perry, John R B

AU - Dorajoo, Rajkumar

AU - Reinmaa, Eva

AU - Salem, Rany M

AU - Sandholm, Niina

AU - Scott, Robert A

AU - Stolk, Lisette

AU - Takahashi, Atsushi

AU - Tanaka, Toshihiro

AU - Van't Hooft, Ferdinand M

AU - Vinkhuyzen, Anna A E

AU - Westra, Harm-Jan

AU - Zheng, Wei

AU - Zondervan, Krina T

AU - Heath, Andrew C

AU - Arveiler, Dominique

AU - Bakker, Stephan J L

AU - Beilby, John

AU - Bergman, Richard N

AU - Blangero, John

AU - Bovet, Pascal

AU - Campbell, Harry

AU - Caulfield, Mark J

AU - Cesana, Giancarlo

AU - Chakravarti, Aravinda

AU - Chasman, Daniel I

AU - Chines, Peter S

AU - Collins, Francis S

AU - Crawford, Dana C

AU - Cupples, L Adrienne

AU - Cusi, Daniele

AU - Danesh, John

AU - de Faire, Ulf

AU - den Ruijter, Hester M

AU - Dominiczak, Anna F

AU - Erbel, Raimund

AU - Erdmann, Jeanette

AU - Eriksson, Johan G

AU - Farrall, Martin

AU - Felix, Stephan B

AU - Ferrannini, Ele

AU - Ferrières, Jean

AU - Ford, Ian

AU - Forouhi, Nita G

AU - Forrester, Terrence

AU - Franco, Oscar H

AU - Gansevoort, Ron T

AU - Gejman, Pablo V

AU - Gieger, Christian

AU - Gottesman, Omri

AU - Gudnason, Vilmundur

AU - Gyllensten, Ulf

AU - Hall, Alistair S

AU - Harris, Tamara B

AU - Hattersley, Andrew T

AU - Hicks, Andrew A

AU - Hindorff, Lucia A

AU - Hingorani, Aroon D

AU - Hofman, Albert

AU - Homuth, Georg

AU - Hovingh, G Kees

AU - Humphries, Steve E

AU - Hunt, Steven C

AU - Hyppönen, Elina

AU - Illig, Thomas

AU - Jacobs, Kevin B

AU - Jarvelin, Marjo-Riitta

AU - Jöckel, Karl-Heinz

AU - Johansen, Berit

AU - Jousilahti, Pekka

AU - Jukema, J Wouter

AU - Jula, Antti M

AU - Kaprio, Jaakko

AU - Kastelein, John J P

AU - Keinanen-Kiukaanniemi, Sirkka M

AU - Kiemeney, Lambertus A

AU - Knekt, Paul

AU - Kooner, Jaspal S

AU - Kooperberg, Charles

AU - Kovacs, Peter

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PY - 2015

Y1 - 2015

N2 - Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

AB - Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

KW - Polymorphism

KW - Obesity: metabolism

KW - Obesity: genetics

KW - Insulin: secretion

KW - Insulin: metabolism

KW - Glutamic Acid: metabolism

KW - Genetic Predisposition to Disease: genetics

KW - Europe: ethnology

KW - Energy Metabolism: genetics

KW - Continental Population Groups: genetics

KW - Adipogenesis: genetics

KW - Adiposity: genetics

KW - Single Nucleotide: genetics

KW - Quantitative Trait Loci: genetics

KW - Synapses: metabolism

U2 - 10.1038/nature14177

DO - 10.1038/nature14177

M3 - Article

VL - 518

SP - 197-U401

JO - Nature

T2 - Nature

JF - Nature

SN - 0028-0836

IS - 7538

ER -