Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people. / Yang, Zhen; Wen, Jie; Tao, Xiaoming; Lu, Bin; Du, Yanping; Wang, Mei; Wang, Xuanchun; Zhang, Weiwei; Gong, Wei; Ling, Charlotte; Wu, Songhua; Hu, Renming.

I: Molecular Biology Reports, Vol. 38, Nr. 2, 2011, s. 1145-1150.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Yang, Z, Wen, J, Tao, X, Lu, B, Du, Y, Wang, M, Wang, X, Zhang, W, Gong, W, Ling, C, Wu, S & Hu, R 2011, 'Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people', Molecular Biology Reports, vol. 38, nr. 2, s. 1145-1150. https://doi.org/10.1007/s11033-010-0212-1

APA

CBE

MLA

Vancouver

Author

Yang, Zhen ; Wen, Jie ; Tao, Xiaoming ; Lu, Bin ; Du, Yanping ; Wang, Mei ; Wang, Xuanchun ; Zhang, Weiwei ; Gong, Wei ; Ling, Charlotte ; Wu, Songhua ; Hu, Renming. / Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people. I: Molecular Biology Reports. 2011 ; Vol. 38, Nr. 2. s. 1145-1150.

RIS

TY - JOUR

T1 - Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people

AU - Yang, Zhen

AU - Wen, Jie

AU - Tao, Xiaoming

AU - Lu, Bin

AU - Du, Yanping

AU - Wang, Mei

AU - Wang, Xuanchun

AU - Zhang, Weiwei

AU - Gong, Wei

AU - Ling, Charlotte

AU - Wu, Songhua

AU - Hu, Renming

PY - 2011

Y1 - 2011

N2 - Recent genome-wide association studies reported that GCKR rs780094 polymorphism is associated with elevated fasting serum triglyceride levels and elevated levels of C-reactive protein (CRP). There are a ample of data on the association between circulating triglyceride, CRP concentrations and risk of non-alcoholic fatty liver (NAFLD). To determine whether the GCKR rs780094 polymorphism contributes to the development of non-alcoholic fatty liver, a case-control study was performed in 903 Chinese subjects. Among study population, 436 patients with B-mode ultrasound-proven NAFLD (318 with steatosis hepatis IA degrees, 90 with steatosis hepatis IIA degrees and 28 with steatosis hepatis IIIA degrees) and 467 controls were genotyped by using TaqMan allelic discrimination assays. We confirmed the association of GCKR rs780094 with NAFLD in Chinese people (OR = 1.607, 95% CI 1.139-2.271, P ([dom]) = 7.2 x 10(-3)). In this study, polymorphism in GCKR rs780094 was not significantly associated with the degree of fatty infiltration of the liver. In addition, the T-allele of GCKR rs780094 was significantly associated with increasing fasting triglyceride (P ([add]) = 3.8 x 10(-4)) and CRP (P ([add]) = 2.9 x 10(-4)) concentrations after adjusting for age, gender, and BMI. The association with NAFLD remained significant after adjustment for triglyceride, while adjustment for CRP abolished the association. Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people. The effect of genotype on NAFLD is probably mediated through chronic low-grade systemic inflammation rather than through dislipidemia.

AB - Recent genome-wide association studies reported that GCKR rs780094 polymorphism is associated with elevated fasting serum triglyceride levels and elevated levels of C-reactive protein (CRP). There are a ample of data on the association between circulating triglyceride, CRP concentrations and risk of non-alcoholic fatty liver (NAFLD). To determine whether the GCKR rs780094 polymorphism contributes to the development of non-alcoholic fatty liver, a case-control study was performed in 903 Chinese subjects. Among study population, 436 patients with B-mode ultrasound-proven NAFLD (318 with steatosis hepatis IA degrees, 90 with steatosis hepatis IIA degrees and 28 with steatosis hepatis IIIA degrees) and 467 controls were genotyped by using TaqMan allelic discrimination assays. We confirmed the association of GCKR rs780094 with NAFLD in Chinese people (OR = 1.607, 95% CI 1.139-2.271, P ([dom]) = 7.2 x 10(-3)). In this study, polymorphism in GCKR rs780094 was not significantly associated with the degree of fatty infiltration of the liver. In addition, the T-allele of GCKR rs780094 was significantly associated with increasing fasting triglyceride (P ([add]) = 3.8 x 10(-4)) and CRP (P ([add]) = 2.9 x 10(-4)) concentrations after adjusting for age, gender, and BMI. The association with NAFLD remained significant after adjustment for triglyceride, while adjustment for CRP abolished the association. Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people. The effect of genotype on NAFLD is probably mediated through chronic low-grade systemic inflammation rather than through dislipidemia.

KW - GCKR

KW - Polymorphism

KW - Non-alcoholic fatty liver disease

KW - CRP

KW - Triglyceride

U2 - 10.1007/s11033-010-0212-1

DO - 10.1007/s11033-010-0212-1

M3 - Article

VL - 38

SP - 1145

EP - 1150

JO - Molecular Biology Reports

T2 - Molecular Biology Reports

JF - Molecular Biology Reports

SN - 0301-4851

IS - 2

ER -