Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

The interaction of bacterial pathogens with their hosts' innate immune systems can be extremely complex and is often difficult to disentangle experimentally. Using mouse models of bacterial infections, several laboratories have successfully applied genetic approaches to identify novel host genes required for innate immune defense. In addition, a variety of creative bacterial genetic schemes have been developed to identify key bacterial genes involved in triggering or evading host immunity. In cases where both the host and pathogen are amenable to genetic manipulation, a combination of host and pathogen genetic approaches can be used. Focusing on bacterial infections of mice, this review summarizes the benefits and limitations of applying genetic analysis to the study of host-pathogen interactions. In particular, we consider how prokaryotic and eukaryotic genetic strategies can be combined, or "squared," to yield new insights in host-pathogen biology.

Detaljer

Författare
Externa organisationer
  • University of California, Berkeley
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Mikrobiologi inom det medicinska området
  • Infektionsmedicin

Nyckelord

Originalspråkengelska
Sidor (från-till)761-78
Antal sidor18
TidskriftImmunogenetics
Volym59
Utgåva nummer10
StatusPublished - 2007 okt
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa