Genome-wide scan for autism susceptibility genes. Paris Autism Research International Sibpair Study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Family and twin studies have suggested a genetic component in autism. We performed a genome-wide screen with 264 microsatellites markers in 51 multiplex families, using non-parametric linkage methods. Families were recruited by a collaborative group including clinicians from Sweden, France, Norway, the USA, Italy, Austria and Belgium. Using two-point and multipoint affected sib-pair analyses, 11 regions gave nominal P -values of 0.05 or lower. Four of these regions overlapped with regions on chromosomes 2q, 7q, 16p and 19p identified by the first genome-wide scan of autism performed by the International Molecular Genetic Study of Autism Consortium. Another of our potential susceptibility regions overlapped with the 15q11-q13 region identified in previous candidate gene studies. Our study revealed six additional regions on chromosomes 4q, 5p, 6q, 10q, 18q and Xp. We found that the most significant multipoint linkage was close to marker D6S283 (maximum lod score = 2.23, P = 0.0013).

Detaljer

Författare
  • Anne Philippe
  • Maria Martinez
  • Michel Guilloud-Bataille
  • Christopher Gillberg
  • Maria Råstam
  • Eili Sponheim
  • Mary Coleman
  • Michele Zappella
  • Harald Aschauer
  • Lionel Van Maldergem
  • Christiane Penet
  • Josué Feingold
  • Alexis Brice
  • Marion Leboyer
Externa organisationer
  • External Organization - Unknown
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Psykiatri
Originalspråkengelska
Sidor (från-till)805-812
TidskriftHuman Molecular Genetics
Volym8
Utgivningsnummer5
StatusPublished - 1999
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa