Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has been proposed as a reliable approximation of NO synthetic capacity in vivo. The objectives of the present study were to test the hypotheses that (i) subjects with combat-related PTSD have lower GABR scores than combat controls, (ii) GABR score is inversely associated with the severity of psychopathological measures, (iii) GABR score is inversely associated with markers of inflammation.

Detaljer

Författare
  • Francesco Saverio Bersani
  • Owen M Wolkowitz
  • Daniel Lindqvist
  • Rachel Yehuda
  • Janine Flory
  • Linda M Bierer
  • Iouri Makotine
  • Duna Abu-Amara
  • Michelle Coy
  • Victor I Reus
  • Elissa S Epel
  • Charles Marmar
  • Synthia H Mellon
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Psykiatri
Originalspråkengelska
Sidor (från-till)153-160
TidskriftBrain Behavior and Immunity
Volym52
Utgivningsnummeroct 26
StatusPublished - 2016
PublikationskategoriForskning
Peer review utfördJa