GLP-1 for type 2 diabetes

Forskningsoutput: TidskriftsbidragÖversiktsartikel


title = "GLP-1 for type 2 diabetes",
abstract = "Glucagon-like peptide-1 (GLP-1)-based therapy of type 2 diabetes is executed either by GLP-1 receptor agonists, which stimulate the GLP-1 receptors, or by dipeptidyl peptidase-4 (DPP-4) inhibitors, which prevent the inactivation of endogenous GLP-1 thereby increasing the concentration of endogenous active GLP-1. GLP-1 activates pancreatic receptors resulting in improved glycemia through glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion. There is also a potential beta cell preservation effect, as judged from rodent studies. GLP-1 receptors are additionally expressed in extrapancreatic tissue, having potential for the treatment to reduce body weight and to potentially have beneficial cardio- and endothelioprotective effects. Clinical trials in subjects with type 2 diabetes have shown that in periods of 12 weeks or more, these treatments reduce HbA1c by approximate to 0.8-1.1% from baseline levels of 7.7-8.5%, and they are efficient both as monotherapy and in combination therapy with metformin, sulfonylureas, thiazolidinediones or insulin. Furthermore, GLP-1 receptor agonists reduce body weight, whereas DPP-4 inhibitors are body weight neutral. The treatment is safe with very low risk for adverse events, including hypoglycaemia. GLP-1 based therapy is thus a novel and now well established therapy of type 2 diabetes, with a particular value in combination with metformin in patients who are inadequately controlled by metformin alone. (C) 2011 Elsevier Inc. All rights reserved.",
keywords = "GLP-1, DPP-4 inhibition, Type 2 diabetes, Exenatide, Liraglutide, Albiglutide, Taspoglutide, Lixisenatide, Sitagliptin, Vildagliptin, Saxagliptin, Alogliptin, Linagliptin",
author = "Bo Ahr{\'e}n",
year = "2011",
doi = "10.1016/j.yexcr.2011.01.010",
language = "English",
volume = "317",
pages = "1239--1245",
journal = "Experimental Cell Research",
issn = "1090-2422",
publisher = "Academic Press",
number = "9",