Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

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Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae. / Schaar, Viveka; Uddbäck, Ida; Nordström, Therése; Riesbeck, Kristian.

I: Journal of Antimicrobial Chemotherapy, Vol. 69, Nr. 1, 2014, s. 117-120.

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T1 - Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

AU - Schaar, Viveka

AU - Uddbäck, Ida

AU - Nordström, Therése

AU - Riesbeck, Kristian

PY - 2014

Y1 - 2014

N2 - Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.

AB - Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.

U2 - 10.1093/jac/dkt307

DO - 10.1093/jac/dkt307

M3 - Article

VL - 69

SP - 117

EP - 120

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 1460-2091

IS - 1

ER -