Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.

Detaljer

Författare
  • Sara Lombardi
  • Gabriella Honeth
  • Christophe Ginestier
  • Ireneusz Shinomiya
  • Rebecca Marlow
  • Bharath Buchupalli
  • Patrycja Gazinska
  • John Brown
  • Steven Catchpole
  • Suling Liu
  • Ariel Barkan
  • Max Wicha
  • Anand Purushotham
  • Joy Burchell
  • Sarah Pinder
  • Gabriela Dontu
Enheter & grupper
Externa organisationer
  • King's College London
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)780-93
Antal sidor14
TidskriftStem Cell Reports
Volym2
Utgivningsnummer6
StatusPublished - 2014 jun 3
PublikationskategoriForskning
Peer review utfördJa