Head posture influences the geometric and hemodynamic features on the healthy human carotid bifurcation

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceeding

Abstract

Atherosclerosis is the third leading cause of morbidity and mortality in the Western world. Low and oscillating wall shear stress (WSS) regions have been previously reported as parameters that correlate with the development of atherosclerosis. In this study we investigated geometric and hemodynamic changes in the carotid bifurcation as a result of posture change. Data from magnetic resonance imaging (MRI) were used to construct three dimensional (3D) surface models and computational fluid dynamic (CFD) fields. Two healthy volunteers were imaged by MRI in three different head postures: a) the supine neutral (N) head position, b) the prone position with leftward head rotation (LR) up to 80° and c) the prone position with rightward head rotation (RR) up to 80°. The area exposure to unfavorable hemodynamics, based on thresholds set for oscillatory shear index (OSI), WSS and relative residence times (RRT), was used to quantify the hemodynamic impact on the wall. Significant change in the hemodynamic burden on the wall was found for the OSI. The velocity profile at the common carotid artery (CCA) upstream of the carotid bifurcation (CB) was investigated at the supine and RR prone position for six healthy volunteers. The results indicated that blood flow rate decreased at peak systole, for the prone position for both the right and left CCAs.

Detaljer

Författare
  • Nicolas Aristokleous
  • Ioannis Seimenis
  • Yannis Papaharilaou
  • Mohammad Iman Khozeymeh
  • Georgios C. Georgiou
  • Brigitta C. Brott
  • Andreas S. Anayiotos
Externa organisationer
  • Cyprus University of Technology
  • Democritus University of Thrace
  • Foundation for Research and Technology - Hellas
  • University of Cyprus
  • University of Alabama
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Radiologi och bildbehandling

Nyckelord

Originalspråkengelska
Titel på värdpublikationIEEE 12th International Conference on BioInformatics and BioEngineering, BIBE 2012
Sidor727-731
Antal sidor5
StatusPublished - 2012 dec 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa
Evenemang12th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2012 - Larnaca, Cypern
Varaktighet: 2012 nov 112012 nov 13

Konferens

Konferens12th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2012
LandCypern
OrtLarnaca
Period2012/11/112012/11/13