Healing of tympanic membrane after myringotomy during Streptococcus pneumoniae otitis media: An otomicroscopic and histologic study in the rat

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The purpose of our study was to elucidate the course of healing of the tympanic membrane (TM) when myringotomy was performed during acute otitis media. The early and long-lasting structural changes of the TM were studied in an animal model. Rats were inoculated with Streptococcus pneumoniae (PnC) type 3 in the bulla. When the infection was manifest, myringotomy was performed. On days 4 and 12, and 3 and 6 months after myringotomy, the TM status was checked by otomicroscopy and TMs were prepared for light and electron microscopy. Comparison was made with PnC-infected TMs that were not perforated, as well as myringotomized noninfected TMs. The infection resolved more slowly in myringotomized ears compared to PnC-infected ears that were left untouched. After 6 months, the pars tensa of the myringotomized infected ears was thickened and showed a disorganized collagen structure, compared with myringotomized noninfected ears, in which TMs were normalized. The PnC- infected TMs without myringotomy were completely normalized after 2 months. We conclude that a combination of bacterial infection and myringotomy causes long-lasting changes in TM structure. This impaired structure of the connective tissue could be of importance in chronic middle ear disease as a presumptive site for retraction and perforation of the TM.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Umeå University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Oto-rino-laryngologi

Nyckelord

Originalspråkengelska
Sidor (från-till)397-404
Antal sidor8
TidskriftAnnals of Otology, Rhinology and Laryngology
Volym105
Utgivningsnummer5
StatusPublished - 1996 maj 1
PublikationskategoriForskning
Peer review utfördJa