Hepatocellular Carcinoma Risk Factors and Disease Burden in a European Cohort: A Nested Case-Control Study.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Background: To date, no attempt has been made to systematically determine the apportionment of the hepatocellular carcinoma burden in Europe or North America among established risk factors.MethodsUsing data collected from 1992 to 2006, which included 4 409 809 person-years in the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 125 case patients with hepatocellular carcinoma, of whom 115 were matched to 229 control subjects. We calculated odds ratios (ORs) for the association of documented risk factors for hepatocellular carcinoma with incidence of this disease and estimated their importance in this European cohort.ResultsChronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection (OR = 9.10, 95% confidence interval [CI] = 2.10 to 39.50 and OR = 13.36, 95% CI = 4.11 to 43.45, respectively), obesity (OR = 2.13, 95% CI = 1.06 to 4.29), former or current smoking (OR = 1.98, 95% CI = 0.90 to 4.39 and OR = 4.55, 95% CI = 1.90 to 10.91, respectively), and heavy alcohol intake (OR = 1.77, 95% CI = 0.73 to 4.27) were associated with hepatocellular carcinoma. Smoking contributed to almost half of all hepatocellular carcinomas (47.6%), whereas 13.2% and 20.9% were attributable to chronic HBV and HCV infection, respectively. Obesity and heavy alcohol intake contributed 16.1% and 10.2%, respectively. Almost two-thirds (65.7%, 95% CI = 50.6% to 79.3%) of hepatocellular carcinomas can be accounted for by exposure to at least one of these documented risk factors.ConclusionsSmoking contributed to more hepatocellular carcinomas in this Europe-wide cohort than chronic HBV and HCV infections. Heavy alcohol consumption and obesity also contributed to sizeable fractions of this disease burden. These contributions may be underestimates because EPIC volunteers are likely to be more health conscious than the general population.

Detaljer

Författare
  • Dimitrios Trichopoulos
  • Christina Bamia
  • Pagona Lagiou
  • Veronika Fedirko
  • Elisabeth Trepo
  • Mazda Jenab
  • Tobias Pischon
  • Ute Nöthlings
  • Kim Overved
  • Anne Tjønneland
  • Malene Outzen
  • Francoise Clavel-Chapelon
  • Rudolf Kaaks
  • Annekatrin Lukanova
  • Heiner Boeing
  • Krasimira Aleksandrova
  • Vassiliki Benetou
  • Dimosthenis Zylis
  • Domenico Palli
  • Valeria Pala
  • Salvatore Panico
  • Rosario Tumino
  • Carlotta Sacerdote
  • H Bas Bueno-De-Mesquita
  • Henk J Van Kranen
  • Petra H M Peeters
  • Eiliv Lund
  • J Ramón Quirós
  • Carlos A González
  • Maria-Jose Sanchez Perez
  • Carmen Navarro
  • Miren Dorronsoro
  • Aurelio Barricarte
  • Björn Lindkvist
  • Mårten Werner
  • Göran Hallmans
  • Kay-Tee Khaw
  • Nick Wareham
  • Timothy Key
  • Isabelle Romieu
  • Shu-Chun Chuang
  • Neil Murphy
  • Paolo Boffetta
  • Antonia Trichopoulou
  • Elio Riboli
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
Originalspråkengelska
Sidor (från-till)1686-1695
TidskriftJournal of the National Cancer Institute
Volym103
StatusPublished - 2011
PublikationskategoriForskning
Peer review utfördJa