Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease. / Singleton, Ellen; Hansson, Oskar; Pijnenburg, Yolande A.L.; La Joie, Renaud; Mantyh, William G.; Tideman, Pontus; Stomrud, Erik; Leuzy, Antoine; Johansson, Maurits; Strandberg, Olof; Smith, Ruben; Berendrecht, Evi; Miller, Bruce L.; Iaccarino, Leonardo; Edwards, Lauren; Strom, Amelia; Wolters, Emma E.; Coomans, Emma; Visser, Denise; Golla, Sandeep S.V.; Tuncel, Hayel; Bouwman, Femke; Van Swieten, John Cornelis; Papma, Janne M.; Van Berckel, Bart; Scheltens, Philip; Dijkstra, Anke A.; Rabinovici, Gil D.; Ossenkoppele, Rik.

I: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 92, Nr. 8, 2021, s. 872-880.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Singleton, E, Hansson, O, Pijnenburg, YAL, La Joie, R, Mantyh, WG, Tideman, P, Stomrud, E, Leuzy, A, Johansson, M, Strandberg, O, Smith, R, Berendrecht, E, Miller, BL, Iaccarino, L, Edwards, L, Strom, A, Wolters, EE, Coomans, E, Visser, D, Golla, SSV, Tuncel, H, Bouwman, F, Van Swieten, JC, Papma, JM, Van Berckel, B, Scheltens, P, Dijkstra, AA, Rabinovici, GD & Ossenkoppele, R 2021, 'Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease', Journal of Neurology, Neurosurgery and Psychiatry, vol. 92, nr. 8, s. 872-880. https://doi.org/10.1136/jnnp-2020-325497

APA

Singleton, E., Hansson, O., Pijnenburg, Y. A. L., La Joie, R., Mantyh, W. G., Tideman, P., Stomrud, E., Leuzy, A., Johansson, M., Strandberg, O., Smith, R., Berendrecht, E., Miller, B. L., Iaccarino, L., Edwards, L., Strom, A., Wolters, E. E., Coomans, E., Visser, D., ... Ossenkoppele, R. (2021). Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 92(8), 872-880. https://doi.org/10.1136/jnnp-2020-325497

CBE

Singleton E, Hansson O, Pijnenburg YAL, La Joie R, Mantyh WG, Tideman P, Stomrud E, Leuzy A, Johansson M, Strandberg O, Smith R, Berendrecht E, Miller BL, Iaccarino L, Edwards L, Strom A, Wolters EE, Coomans E, Visser D, Golla SSV, Tuncel H, Bouwman F, Van Swieten JC, Papma JM, Van Berckel B, Scheltens P, Dijkstra AA, Rabinovici GD, Ossenkoppele R. 2021. Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry. 92(8):872-880. https://doi.org/10.1136/jnnp-2020-325497

MLA

Vancouver

Author

Singleton, Ellen ; Hansson, Oskar ; Pijnenburg, Yolande A.L. ; La Joie, Renaud ; Mantyh, William G. ; Tideman, Pontus ; Stomrud, Erik ; Leuzy, Antoine ; Johansson, Maurits ; Strandberg, Olof ; Smith, Ruben ; Berendrecht, Evi ; Miller, Bruce L. ; Iaccarino, Leonardo ; Edwards, Lauren ; Strom, Amelia ; Wolters, Emma E. ; Coomans, Emma ; Visser, Denise ; Golla, Sandeep S.V. ; Tuncel, Hayel ; Bouwman, Femke ; Van Swieten, John Cornelis ; Papma, Janne M. ; Van Berckel, Bart ; Scheltens, Philip ; Dijkstra, Anke A. ; Rabinovici, Gil D. ; Ossenkoppele, Rik. / Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease. I: Journal of Neurology, Neurosurgery and Psychiatry. 2021 ; Vol. 92, Nr. 8. s. 872-880.

RIS

TY - JOUR

T1 - Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease

AU - Singleton, Ellen

AU - Hansson, Oskar

AU - Pijnenburg, Yolande A.L.

AU - La Joie, Renaud

AU - Mantyh, William G.

AU - Tideman, Pontus

AU - Stomrud, Erik

AU - Leuzy, Antoine

AU - Johansson, Maurits

AU - Strandberg, Olof

AU - Smith, Ruben

AU - Berendrecht, Evi

AU - Miller, Bruce L.

AU - Iaccarino, Leonardo

AU - Edwards, Lauren

AU - Strom, Amelia

AU - Wolters, Emma E.

AU - Coomans, Emma

AU - Visser, Denise

AU - Golla, Sandeep S.V.

AU - Tuncel, Hayel

AU - Bouwman, Femke

AU - Van Swieten, John Cornelis

AU - Papma, Janne M.

AU - Van Berckel, Bart

AU - Scheltens, Philip

AU - Dijkstra, Anke A.

AU - Rabinovici, Gil D.

AU - Ossenkoppele, Rik

PY - 2021

Y1 - 2021

N2 - Objective: The clinical phenotype of the rare behavioural variant of Alzheimer's disease (bvAD) is insufficiently understood. Given the strong clinico-anatomical correlations of tau pathology in AD, we investigated the distribution of tau deposits in bvAD, in-vivo and ex-vivo, using positron emission tomography (PET) and postmortem examination. Methods: For the tau PET study, seven amyloid-β positive bvAD patients underwent [18F]flortaucipir or [18F]RO948 PET. We converted tau PET uptake values into standardised (W-)scores, adjusting for age, sex and mini mental state examination in a 'typical' memory-predominant AD (n=205) group. W-scores were computed within entorhinal, temporoparietal, medial and lateral prefrontal, insular and whole-brain regions-of-interest, frontal-to-entorhinal and frontal-to-parietal ratios and within intrinsic functional connectivity network templates. For the postmortem study, the percentage of AT8 (tau)-positive area in hippocampus CA1, temporal, parietal, frontal and insular cortices were compared between autopsy-confirmed patients with bvAD (n=8) and typical AD (tAD;n=7). Results: Individual regional W-scores ≥1.96 (corresponding to p<0.05) were observed in three cases, that is, case #5: medial prefrontal cortex (W=2.13) and anterior default mode network (W=3.79), case #2: lateral prefrontal cortex (W=2.79) and salience network (W=2.77), and case #7: frontal-to-entorhinal ratio (W=2.04). The remaining four cases fell within the normal distributions of the tAD group. Postmortem AT8 staining indicated no group-level regional differences in phosphorylated tau levels between bvAD and tAD (all p>0.05). Conclusions: Both in-vivo and ex-vivo, patients with bvAD showed heterogeneous distributions of tau pathology. Since key regions involved in behavioural regulation were not consistently disproportionally affected by tau pathology, other factors are more likely driving the clinical phenotype in bvAD.

AB - Objective: The clinical phenotype of the rare behavioural variant of Alzheimer's disease (bvAD) is insufficiently understood. Given the strong clinico-anatomical correlations of tau pathology in AD, we investigated the distribution of tau deposits in bvAD, in-vivo and ex-vivo, using positron emission tomography (PET) and postmortem examination. Methods: For the tau PET study, seven amyloid-β positive bvAD patients underwent [18F]flortaucipir or [18F]RO948 PET. We converted tau PET uptake values into standardised (W-)scores, adjusting for age, sex and mini mental state examination in a 'typical' memory-predominant AD (n=205) group. W-scores were computed within entorhinal, temporoparietal, medial and lateral prefrontal, insular and whole-brain regions-of-interest, frontal-to-entorhinal and frontal-to-parietal ratios and within intrinsic functional connectivity network templates. For the postmortem study, the percentage of AT8 (tau)-positive area in hippocampus CA1, temporal, parietal, frontal and insular cortices were compared between autopsy-confirmed patients with bvAD (n=8) and typical AD (tAD;n=7). Results: Individual regional W-scores ≥1.96 (corresponding to p<0.05) were observed in three cases, that is, case #5: medial prefrontal cortex (W=2.13) and anterior default mode network (W=3.79), case #2: lateral prefrontal cortex (W=2.79) and salience network (W=2.77), and case #7: frontal-to-entorhinal ratio (W=2.04). The remaining four cases fell within the normal distributions of the tAD group. Postmortem AT8 staining indicated no group-level regional differences in phosphorylated tau levels between bvAD and tAD (all p>0.05). Conclusions: Both in-vivo and ex-vivo, patients with bvAD showed heterogeneous distributions of tau pathology. Since key regions involved in behavioural regulation were not consistently disproportionally affected by tau pathology, other factors are more likely driving the clinical phenotype in bvAD.

U2 - 10.1136/jnnp-2020-325497

DO - 10.1136/jnnp-2020-325497

M3 - Article

C2 - 33850001

AN - SCOPUS:85104490625

VL - 92

SP - 872

EP - 880

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 1468-330X

IS - 8

ER -