High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat

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Abstract

High frequency stimulation (HFS) of the subthalamic nucleus (STN) can partially alleviate motor symptoms in patients with Parkinson's disease (PD). However, the mechanism of action of HFS is incompletely understood. We investigated the effect of HFS (130 Hz) and low frequency stimulation (LFS, 20 Hz) of the STN on striatal dopaminergic transmission and metabolism using in vivo microdialysis in anaesthetized and freely moving rats. While LFS had no effect, HFS of the STN produced a delayed, stable and intensity-dependent increase of extracellular dopamine metabolites. Striatal extracellular levels of dopamine and 5-HIAA were not influenced by HFS or LFS in the present experimental paradigm. We conclude that HFS of the STN influences striatal dopaminergic metabolism in naive, nonlesioned rats.

Detaljer

Författare
  • G Paul
  • Torsten Reum
  • Wlodzimierz Meissner
  • A Marburger
  • Reinhard Sohr
  • R Morgenstern
  • A Kupsch
Externa organisationer
  • Humboldt University of Berlin
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)441-4
Antal sidor4
TidskriftNeuroReport
Volym11
Utgåva nummer3
StatusPublished - 2000 feb 28
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa