High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat

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High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat. / Paul, G; Reum, Torsten; Meissner, Wlodzimierz; Marburger, A; Sohr, Reinhard; Morgenstern, R; Kupsch, A.

I: NeuroReport, Vol. 11, Nr. 3, 28.02.2000, s. 441-4.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Paul, G, Reum, T, Meissner, W, Marburger, A, Sohr, R, Morgenstern, R & Kupsch, A 2000, 'High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat', NeuroReport, vol. 11, nr. 3, s. 441-4.

APA

Paul, G., Reum, T., Meissner, W., Marburger, A., Sohr, R., Morgenstern, R., & Kupsch, A. (2000). High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat. NeuroReport, 11(3), 441-4.

CBE

Paul G, Reum T, Meissner W, Marburger A, Sohr R, Morgenstern R, Kupsch A. 2000. High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat. NeuroReport. 11(3):441-4.

MLA

Vancouver

Paul G, Reum T, Meissner W, Marburger A, Sohr R, Morgenstern R et al. High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat. NeuroReport. 2000 feb 28;11(3):441-4.

Author

Paul, G ; Reum, Torsten ; Meissner, Wlodzimierz ; Marburger, A ; Sohr, Reinhard ; Morgenstern, R ; Kupsch, A. / High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat. I: NeuroReport. 2000 ; Vol. 11, Nr. 3. s. 441-4.

RIS

TY - JOUR

T1 - High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat

AU - Paul, G

AU - Reum, Torsten

AU - Meissner, Wlodzimierz

AU - Marburger, A

AU - Sohr, Reinhard

AU - Morgenstern, R

AU - Kupsch, A

PY - 2000/2/28

Y1 - 2000/2/28

N2 - High frequency stimulation (HFS) of the subthalamic nucleus (STN) can partially alleviate motor symptoms in patients with Parkinson's disease (PD). However, the mechanism of action of HFS is incompletely understood. We investigated the effect of HFS (130 Hz) and low frequency stimulation (LFS, 20 Hz) of the STN on striatal dopaminergic transmission and metabolism using in vivo microdialysis in anaesthetized and freely moving rats. While LFS had no effect, HFS of the STN produced a delayed, stable and intensity-dependent increase of extracellular dopamine metabolites. Striatal extracellular levels of dopamine and 5-HIAA were not influenced by HFS or LFS in the present experimental paradigm. We conclude that HFS of the STN influences striatal dopaminergic metabolism in naive, nonlesioned rats.

AB - High frequency stimulation (HFS) of the subthalamic nucleus (STN) can partially alleviate motor symptoms in patients with Parkinson's disease (PD). However, the mechanism of action of HFS is incompletely understood. We investigated the effect of HFS (130 Hz) and low frequency stimulation (LFS, 20 Hz) of the STN on striatal dopaminergic transmission and metabolism using in vivo microdialysis in anaesthetized and freely moving rats. While LFS had no effect, HFS of the STN produced a delayed, stable and intensity-dependent increase of extracellular dopamine metabolites. Striatal extracellular levels of dopamine and 5-HIAA were not influenced by HFS or LFS in the present experimental paradigm. We conclude that HFS of the STN influences striatal dopaminergic metabolism in naive, nonlesioned rats.

KW - 3,4-Dihydroxyphenylacetic Acid

KW - Animals

KW - Corpus Striatum

KW - Dopamine

KW - Electric Stimulation

KW - Extracellular Space

KW - Homovanillic Acid

KW - Male

KW - Movement Disorders

KW - Rats

KW - Rats, Wistar

KW - Subthalamic Nucleus

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

C2 - 10718291

VL - 11

SP - 441

EP - 444

JO - NeuroReport

JF - NeuroReport

SN - 1473-558X

IS - 3

ER -