High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.

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High levels of cathepsin D and cystatin B are associated with increased risk of coronary events. / Goncalves, Isabel; Hultman, Karin; Dunér, Pontus; Edsfeldt, Andreas; Hedblad, Bo; Nordin Fredrikson, Gunilla; Björkbacka, Harry; Nilsson, Jan; Bengtsson, Eva.

I: Open Heart, Vol. 3, Nr. 1, 2016, s. e000353.

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T1 - High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.

AU - Goncalves, Isabel

AU - Hultman, Karin

AU - Dunér, Pontus

AU - Edsfeldt, Andreas

AU - Hedblad, Bo

AU - Nordin Fredrikson, Gunilla

AU - Björkbacka, Harry

AU - Nilsson, Jan

AU - Bengtsson, Eva

PY - 2016

Y1 - 2016

N2 - The majority of acute coronary syndromes are caused by plaque ruptures. Proteases secreted by macrophages play an important role in plaque ruptures by degrading extracellular matrix proteins in the fibrous cap. Matrix metalloproteinases have been shown to be markers for cardiovascular disease whereas the members of the cathepsin protease family are less studied.

AB - The majority of acute coronary syndromes are caused by plaque ruptures. Proteases secreted by macrophages play an important role in plaque ruptures by degrading extracellular matrix proteins in the fibrous cap. Matrix metalloproteinases have been shown to be markers for cardiovascular disease whereas the members of the cathepsin protease family are less studied.

U2 - 10.1136/openhrt-2015-000353

DO - 10.1136/openhrt-2015-000353

M3 - Article

VL - 3

SP - e000353

JO - Open Heart

T2 - Open Heart

JF - Open Heart

SN - 2053-3624

IS - 1

ER -