High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhage

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhage. / Gazzolo, D; Marinoni, E; Di Iorio, R; Lituania, M; Marras, M; Bruschettini, Matteo; Bruschettini, P; Frulio, R; Michetti, F; Petraglia, F; Florio, P.

I: Clinical Chemistry, Vol. 52, Nr. 5, 2006, s. 819-826.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Gazzolo, D, Marinoni, E, Di Iorio, R, Lituania, M, Marras, M, Bruschettini, M, Bruschettini, P, Frulio, R, Michetti, F, Petraglia, F & Florio, P 2006, 'High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhage', Clinical Chemistry, vol. 52, nr. 5, s. 819-826. https://doi.org/10.1373/clinchem.2005.060665

APA

Gazzolo, D., Marinoni, E., Di Iorio, R., Lituania, M., Marras, M., Bruschettini, M., Bruschettini, P., Frulio, R., Michetti, F., Petraglia, F., & Florio, P. (2006). High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhage. Clinical Chemistry, 52(5), 819-826. https://doi.org/10.1373/clinchem.2005.060665

CBE

Gazzolo D, Marinoni E, Di Iorio R, Lituania M, Marras M, Bruschettini M, Bruschettini P, Frulio R, Michetti F, Petraglia F, Florio P. 2006. High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhage. Clinical Chemistry. 52(5):819-826. https://doi.org/10.1373/clinchem.2005.060665

MLA

Vancouver

Author

Gazzolo, D ; Marinoni, E ; Di Iorio, R ; Lituania, M ; Marras, M ; Bruschettini, Matteo ; Bruschettini, P ; Frulio, R ; Michetti, F ; Petraglia, F ; Florio, P. / High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhage. I: Clinical Chemistry. 2006 ; Vol. 52, Nr. 5. s. 819-826.

RIS

TY - JOUR

T1 - High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhage

AU - Gazzolo, D

AU - Marinoni, E

AU - Di Iorio, R

AU - Lituania, M

AU - Marras, M

AU - Bruschettini, Matteo

AU - Bruschettini, P

AU - Frulio, R

AU - Michetti, F

AU - Petraglia, F

AU - Florio, P

PY - 2006

Y1 - 2006

N2 - Background: Intrauterine growth restriction (IUGR) is associated with perinatal mortality and with neurologic damage from intraventricular hemorrhage (IVH). We investigated whether S100B, a neural protein found in high concentrations after cell injury in the nervous system, is increased in serum of women whose pregnancies are complicated by IUGR and whose newborns develop IVH. We also explored the prognostic accuracy of maternal serum S100B for IVH in the newborn. Methods: We conducted a case-control study of 106 pregnancies complicated by IUGR, including a subgroup (n = 26) who developed IVH after birth, and 212 unaffected pregnancies matched for gestational age. Ultrasound examination, Doppler velocimetry patterns (in the utero-placental vessels and middle cerebral artery), and maternal blood collection were performed before birth; cerebral ultrasound and neurologic examinations were performed after birth. Results: S100B was higher (P < 0.001) in IUGR pregnancies complicated by IVH than in those that were not and in controls. At a cutoff of 0.72 mu g/L, sensitivity was 100% [95% confidence interval (95% CI), 87%-100%] and specificity was 99.3% (97.5%-99.9%) for prediction of IVH (area under the ROC curve, 0.999). The prevalence of IVH was 8.2% in the whole study population, 93% (95% CI, 83.6%-100%) in those with maternal S100B > 0.72 mu g/L, and 0% (0%-2.5%) in those with maternal S100B < 0.72 mu g/L. Conclusion: For prediction of IVH, measurements of maternal S100B may be useful at times before clinical, laboratory, and ultrasound patterns can identify risk of IVH. (c) 2006 American Association for Clinical Chemistry.

AB - Background: Intrauterine growth restriction (IUGR) is associated with perinatal mortality and with neurologic damage from intraventricular hemorrhage (IVH). We investigated whether S100B, a neural protein found in high concentrations after cell injury in the nervous system, is increased in serum of women whose pregnancies are complicated by IUGR and whose newborns develop IVH. We also explored the prognostic accuracy of maternal serum S100B for IVH in the newborn. Methods: We conducted a case-control study of 106 pregnancies complicated by IUGR, including a subgroup (n = 26) who developed IVH after birth, and 212 unaffected pregnancies matched for gestational age. Ultrasound examination, Doppler velocimetry patterns (in the utero-placental vessels and middle cerebral artery), and maternal blood collection were performed before birth; cerebral ultrasound and neurologic examinations were performed after birth. Results: S100B was higher (P < 0.001) in IUGR pregnancies complicated by IVH than in those that were not and in controls. At a cutoff of 0.72 mu g/L, sensitivity was 100% [95% confidence interval (95% CI), 87%-100%] and specificity was 99.3% (97.5%-99.9%) for prediction of IVH (area under the ROC curve, 0.999). The prevalence of IVH was 8.2% in the whole study population, 93% (95% CI, 83.6%-100%) in those with maternal S100B > 0.72 mu g/L, and 0% (0%-2.5%) in those with maternal S100B < 0.72 mu g/L. Conclusion: For prediction of IVH, measurements of maternal S100B may be useful at times before clinical, laboratory, and ultrasound patterns can identify risk of IVH. (c) 2006 American Association for Clinical Chemistry.

U2 - 10.1373/clinchem.2005.060665

DO - 10.1373/clinchem.2005.060665

M3 - Article

VL - 52

SP - 819

EP - 826

JO - Clinical Chemistry

JF - Clinical Chemistry

SN - 0009-9147

IS - 5

ER -