High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols

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High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols. / Paulsson, Kajsa; Forestier, Erik; Andersen, Mette K.; Autio, Kirsi; Barbany, Gisela; Borgstrom, Georg; Cavelier, Lucia; Golovleva, Irina; Heim, Sverre; Heinonen, Kristiina; Hovland, Randi; Johannsson, Johann H.; Kjeldsen, Eigil; Nordgren, Ann; Palmqvist, Lars; Johansson, Bertil.

I: Haematologica, Vol. 98, Nr. 9, 2013, s. 1424-1432.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Paulsson, K, Forestier, E, Andersen, MK, Autio, K, Barbany, G, Borgstrom, G, Cavelier, L, Golovleva, I, Heim, S, Heinonen, K, Hovland, R, Johannsson, JH, Kjeldsen, E, Nordgren, A, Palmqvist, L & Johansson, B 2013, 'High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols', Haematologica, vol. 98, nr. 9, s. 1424-1432. https://doi.org/10.3324/haematol.2013.085852

APA

CBE

Paulsson K, Forestier E, Andersen MK, Autio K, Barbany G, Borgstrom G, Cavelier L, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kjeldsen E, Nordgren A, Palmqvist L, Johansson B. 2013. High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols. Haematologica. 98(9):1424-1432. https://doi.org/10.3324/haematol.2013.085852

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Author

Paulsson, Kajsa ; Forestier, Erik ; Andersen, Mette K. ; Autio, Kirsi ; Barbany, Gisela ; Borgstrom, Georg ; Cavelier, Lucia ; Golovleva, Irina ; Heim, Sverre ; Heinonen, Kristiina ; Hovland, Randi ; Johannsson, Johann H. ; Kjeldsen, Eigil ; Nordgren, Ann ; Palmqvist, Lars ; Johansson, Bertil. / High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols. I: Haematologica. 2013 ; Vol. 98, Nr. 9. s. 1424-1432.

RIS

TY - JOUR

T1 - High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols

AU - Paulsson, Kajsa

AU - Forestier, Erik

AU - Andersen, Mette K.

AU - Autio, Kirsi

AU - Barbany, Gisela

AU - Borgstrom, Georg

AU - Cavelier, Lucia

AU - Golovleva, Irina

AU - Heim, Sverre

AU - Heinonen, Kristiina

AU - Hovland, Randi

AU - Johannsson, Johann H.

AU - Kjeldsen, Eigil

AU - Nordgren, Ann

AU - Palmqvist, Lars

AU - Johansson, Bertil

PY - 2013

Y1 - 2013

N2 - Between 1992 and 2008, 713 high hyperdiploid acute lymphoblastic leukemias in children aged 1-15 years were diagnosed and treated according to the Nordic Society for Pediatric Hematology and Oncology acute lymphoblastic leukemia 1992/2000 protocols. Twenty (2.8%) harbored t(1;19), t(9; 22), der(11q23), or t(12; 21). The median age of patients with "classic" high hyperdiploidy was lower than that of patients with translocation-positive high hyperdiploidy (P<0.001). Cases with triple trisomies (+4, +10, +17), comprising 50%, had higher modal numbers than the triple trisomy-negative cases (P<0.0001). The probabilities of event-free survival and overall survival were lower for those with white blood cell counts 250x10(9)/L (P=0.017/P=0.009), >5% bone marrow blasts at day 29 (P=0.001/0.002), and for high-risk patients (P<0.001/P=0.003), whereas event-free, but not overall, survival, was higher for cases with gains of chromosomes 4 (P<0.0001), 6 (P<0.003), 17 (P=0.010), 18 (P=0.049), and 22 (P=0.040), triple trisomies (P=0.002), and modal numbers >53/55 (P=0.020/0.024). In multivariate analyses, modal number and triple trisomies were significantly associated with superior event-free survival in separate analyses with age and white blood cell counts. When including both modal numbers and triple trisomies, only low white blood cell counts were significantly associated with superior event-free survival (P=0.009). We conclude that high modal chromosome numbers and triple trisomies are highly correlated prognostic factors and that these two parameters identify the same subgroup of patients characterized by a particularly favorable outcome.

AB - Between 1992 and 2008, 713 high hyperdiploid acute lymphoblastic leukemias in children aged 1-15 years were diagnosed and treated according to the Nordic Society for Pediatric Hematology and Oncology acute lymphoblastic leukemia 1992/2000 protocols. Twenty (2.8%) harbored t(1;19), t(9; 22), der(11q23), or t(12; 21). The median age of patients with "classic" high hyperdiploidy was lower than that of patients with translocation-positive high hyperdiploidy (P<0.001). Cases with triple trisomies (+4, +10, +17), comprising 50%, had higher modal numbers than the triple trisomy-negative cases (P<0.0001). The probabilities of event-free survival and overall survival were lower for those with white blood cell counts 250x10(9)/L (P=0.017/P=0.009), >5% bone marrow blasts at day 29 (P=0.001/0.002), and for high-risk patients (P<0.001/P=0.003), whereas event-free, but not overall, survival, was higher for cases with gains of chromosomes 4 (P<0.0001), 6 (P<0.003), 17 (P=0.010), 18 (P=0.049), and 22 (P=0.040), triple trisomies (P=0.002), and modal numbers >53/55 (P=0.020/0.024). In multivariate analyses, modal number and triple trisomies were significantly associated with superior event-free survival in separate analyses with age and white blood cell counts. When including both modal numbers and triple trisomies, only low white blood cell counts were significantly associated with superior event-free survival (P=0.009). We conclude that high modal chromosome numbers and triple trisomies are highly correlated prognostic factors and that these two parameters identify the same subgroup of patients characterized by a particularly favorable outcome.

U2 - 10.3324/haematol.2013.085852

DO - 10.3324/haematol.2013.085852

M3 - Article

VL - 98

SP - 1424

EP - 1432

JO - Haematologica-The Hematology Journal

T2 - Haematologica-The Hematology Journal

JF - Haematologica-The Hematology Journal

SN - 1592-8721

IS - 9

ER -