High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.
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High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events. / Rattik, Sara; Wigren, Maria; Björkbacka, Harry; Nordin Fredrikson, Gunilla; Hedblad, Bo; Siegbahn, Agneta; Bengtsson, Eva; Schiopu, Alexandru; Edsfeldt, Andreas; Dunér, Pontus; Grufman, Helena; Goncalves, Isabel; Nilsson, Jan.
I: Arteriosclerosis, Thrombosis and Vascular Biology, Vol. 35, Nr. 1, 2015, s. 222-228.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
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T1 - High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.
AU - Rattik, Sara
AU - Wigren, Maria
AU - Björkbacka, Harry
AU - Nordin Fredrikson, Gunilla
AU - Hedblad, Bo
AU - Siegbahn, Agneta
AU - Bengtsson, Eva
AU - Schiopu, Alexandru
AU - Edsfeldt, Andreas
AU - Dunér, Pontus
AU - Grufman, Helena
AU - Goncalves, Isabel
AU - Nilsson, Jan
PY - 2015
Y1 - 2015
N2 - Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosclerotic plaques have received less attention. The present study aimed to investigate whether plasma levels of the smooth muscle cell growth factor epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and platelet-derived growth factor correlate with plaque phenotype and incidence of CEs.
AB - Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosclerotic plaques have received less attention. The present study aimed to investigate whether plasma levels of the smooth muscle cell growth factor epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and platelet-derived growth factor correlate with plaque phenotype and incidence of CEs.
U2 - 10.1161/ATVBAHA.114.304369
DO - 10.1161/ATVBAHA.114.304369
M3 - Article
VL - 35
SP - 222
EP - 228
JO - Arteriosclerosis, Thrombosis and Vascular Biology
JF - Arteriosclerosis, Thrombosis and Vascular Biology
SN - 1524-4636
IS - 1
ER -