High-risk HPV and survival in patients with oral and oropharyngeal squamous cell carcinoma - 5-year follow up of a population-based study.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Abstract Conclusion: No statistically significant 5-year survival difference was seen in patients with oral and oropharyngeal squamous cell carcinoma (OOPSCC) between high-risk HPV-positive and -negative groups in this population-based study. Objectives: To see if the formerly observed higher risk for recurrence or second primary tumour (SPT) in high-risk HPV-positive patients with OOPSCC corresponds to worse survival. Methods: A total of 128 consecutive, previously untreated patients with OOPSCC, who were part of a population-based case-control study in southern Sweden during 2000-2004, were included. A mouthwash sample was collected and exfoliated cells were collected with cotton-tipped swabs from the tonsillar fossa and the tumour. Specimens were analysed for HPV DNA using nested polymerase chain reaction (PCR). Disease-specific survival (DSS) and DSS difference between HPV-negative and HPV-positive patients were calculated. The relationship between age, stage, high-risk HPV status and DSS was assessed. Oral and oropharyngeal tumours were assessed separately. Results: Mean DSS in months was 80.7/68.6 (high-risk HPV-negative/high-risk HPV-positive) for oral cavity tumours (p = 0.18) and 67.6/78.3 (high-risk HPV-negative/high-risk HPV-positive) for oropharyngeal tumours (p = 0.47). For oral cavity tumours, age, T status, N status and stage all showed significant differences in DSS. For oropharyngeal tumours, no significant difference regarding DSS was found.


  • Karin Annertz
  • Kerstin Rosenquist
  • Gunilla Andersson
  • Helene Jacobsson
  • Bengt-Göran Hansson
  • Johan Wennerberg
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Oto-rino-laryngologi
Sidor (från-till)843-851
TidskriftActa Oto-Laryngologica
Utgåva nummer8
StatusPublished - 2014
Peer review utfördJa

Relaterad forskningsoutput

Karin Annertz, 2014, Lund University, Faculty of Medicine, Otorhinolaryngology (Lund). 144 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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