Histological improvement of liver fibrosis in well-treated patients with autoimmune hepatitis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that if left untreated may lead to the development of cirrhosis. Previous studies on AIH patients have suggested that fibrosis and even cirrhosis can be reversed by medical treatment. The aim of this study was to evaluate the efficacy of medical treatment for protection of developing fibrosis and cirrhosis. A total of 258 liver biopsies from 101 patients (72 women, 29 men) were analyzed by a single pathologist and classified according to the Ishak grading (inflammation) and staging (fibrosis) system. Liver histology was stratified according to the temporal changes of fibrosis stage (increased, decreased, or stable), and groups were compared. Complete or partial response to medical treatment was 94.9%. Reduction of fibrosis stage from the first to the last biopsy was seen in 63 patients (62.4%). We found an association between a reduction in the fibrosis stage and continuous glucocorticoid medication, as well as lowered scores of inflammation at last biopsy. Twenty-one patients had cirrhosis (Ishak stage 6) at least in one of the previous biopsies, but only 5 patients at the last biopsy. Histological improvement is common in AIH patients that respond to medical treatment, and a reduction or stabilization of fibrosis stage occurs in about 2/3 of such patients.


  • Åsa Danielsson Borssén
  • Richard Palmqvist
  • Stergios Kechagias
  • Hanns-Ulrich Marschall
  • Annika Bergquist
  • Fredrik Rorsman
  • Ola Weiland
  • Hans Verbaan
  • Nils Nyhlin
  • Emma Nilsson
  • Mårten Werner
Enheter & grupper
Externa organisationer
  • Norrland University Hospital
  • Umeå University
  • Linköping University
  • Sahlgrenska Academy
  • Karolinska University Hospital
  • Uppsala universitet, Historiska institutionen
  • Örebro University

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Gastroenterologi


TidskriftMedicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
StatusPublished - 2017 aug 1
Peer review utfördJa