Histopathological and cell biological factors of ductal carcinoma in situ before and after the introduction of mammographic screening

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Bibtex

@article{0b85da27673d44d48f971f36d4a34dc7,
title = "Histopathological and cell biological factors of ductal carcinoma in situ before and after the introduction of mammographic screening",
abstract = "With the introduction of mammographic screening the incidence of ductal carcinoma in situ (DCIS) has increased to 10-15{\%} of all breast cancers. The aim of this study was to investigate whether there were any morphological and cell biological differences between DCIS detected during the pre-screening (n = 39) as opposed to the screening period (n = 120). We could not demonstrate any statistically significant differences between the pre-screening and the screening period with regard to nuclear grade, presence of necrosis, the Van Nuys classification system, growth pattern, or cell biological factors (estrogen and progesterone receptors, c-erbB-2, p53, DNA ploidy status, Ki67, and Auer classes). These findings suggest that DCIS tumors detected during the two time periods have a similar malignant potential. DCIS detected during the screening period was further divided into the prevalence period versus the period thereafter, and symptomatic versus screening-detected asymptomatic cases. More cases with diffuse growth patterns were seen during the prevalence period than after the prevalence period, and screening-detected asymptomatic DCISs were more often 15 mm or smaller in diameter than DCISs detected symptomatically.",
author = "Ingrid Idvall and Christina Andersson and Ghita Fallenius and Christian Ingvar and Anita Ringberg and Carina Forsare and M{\aa}ns {\AA}kerman and M{\aa}rten Fern{\"o}",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Surgery Research Unit (013242220), Surgery (Lund) (013009000), Oncology, MV (013035000)",
year = "2001",
doi = "10.1080/028418601750444222",
language = "English",
volume = "40",
pages = "653--659",
journal = "Acta Oncologica",
issn = "1651-226X",
publisher = "Taylor & Francis",
number = "5",

}