Histopathological and cell biological factors of ductal carcinoma in situ before and after the introduction of mammographic screening

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Histopathological and cell biological factors of ductal carcinoma in situ before and after the introduction of mammographic screening. / Idvall, Ingrid; Andersson, Christina; Fallenius, Ghita; Ingvar, Christian; Ringberg, Anita; Forsare, Carina; Åkerman, Måns; Fernö, Mårten.

I: Acta Oncologica, Vol. 40, Nr. 5, 2001, s. 653-659.

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T1 - Histopathological and cell biological factors of ductal carcinoma in situ before and after the introduction of mammographic screening

AU - Idvall, Ingrid

AU - Andersson, Christina

AU - Fallenius, Ghita

AU - Ingvar, Christian

AU - Ringberg, Anita

AU - Forsare, Carina

AU - Åkerman, Måns

AU - Fernö, Mårten

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Surgery Research Unit (013242220), Surgery (Lund) (013009000), Oncology, MV (013035000)

PY - 2001

Y1 - 2001

N2 - With the introduction of mammographic screening the incidence of ductal carcinoma in situ (DCIS) has increased to 10-15% of all breast cancers. The aim of this study was to investigate whether there were any morphological and cell biological differences between DCIS detected during the pre-screening (n = 39) as opposed to the screening period (n = 120). We could not demonstrate any statistically significant differences between the pre-screening and the screening period with regard to nuclear grade, presence of necrosis, the Van Nuys classification system, growth pattern, or cell biological factors (estrogen and progesterone receptors, c-erbB-2, p53, DNA ploidy status, Ki67, and Auer classes). These findings suggest that DCIS tumors detected during the two time periods have a similar malignant potential. DCIS detected during the screening period was further divided into the prevalence period versus the period thereafter, and symptomatic versus screening-detected asymptomatic cases. More cases with diffuse growth patterns were seen during the prevalence period than after the prevalence period, and screening-detected asymptomatic DCISs were more often 15 mm or smaller in diameter than DCISs detected symptomatically.

AB - With the introduction of mammographic screening the incidence of ductal carcinoma in situ (DCIS) has increased to 10-15% of all breast cancers. The aim of this study was to investigate whether there were any morphological and cell biological differences between DCIS detected during the pre-screening (n = 39) as opposed to the screening period (n = 120). We could not demonstrate any statistically significant differences between the pre-screening and the screening period with regard to nuclear grade, presence of necrosis, the Van Nuys classification system, growth pattern, or cell biological factors (estrogen and progesterone receptors, c-erbB-2, p53, DNA ploidy status, Ki67, and Auer classes). These findings suggest that DCIS tumors detected during the two time periods have a similar malignant potential. DCIS detected during the screening period was further divided into the prevalence period versus the period thereafter, and symptomatic versus screening-detected asymptomatic cases. More cases with diffuse growth patterns were seen during the prevalence period than after the prevalence period, and screening-detected asymptomatic DCISs were more often 15 mm or smaller in diameter than DCISs detected symptomatically.

U2 - 10.1080/028418601750444222

DO - 10.1080/028418601750444222

M3 - Article

VL - 40

SP - 653

EP - 659

JO - Acta Oncologica

JF - Acta Oncologica

SN - 1651-226X

IS - 5

ER -