Homocystein--markör för kärlsjukdom hos aldre med psykisk sjukdom.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Many studies have reported higher total plasma homocysteine (tHcy) in elderly patients with mental illness than in control subjects. There are many different determinants of plasma tHcy concentration, including age, cobalamin/folate status, renal function and the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. We have investigated elderly patients with regard to plasma tHcy and the presence of vascular disease. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors such as age and genetics. The main findings in our studies imply that elevated plasma tHcy concentration in elderly patients with mental illness is mainly associated with the presence of vascular disease and is not related to the specific psychogeriatric diagnosis. Furthermore, it seems possible that the control of conventional vascular risk factors could be guided by the level of plasma tHcy, serum cystatin C, and serum N-terminal pro-brain natriuretic peptide. Patients with an elevation of any of these parameters could be selected for a lower target level of vascular risk factors such as blood pressure cholesterol etc. than conventional target levels.

Detaljer

Författare
  • Björn Hultberg
  • Anna-Karin Nilsson
  • Lars Gustafson
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Läkemedelskemi
  • Farmakologi och toxikologi

Nyckelord

Originalspråksvenska
Sidor (från-till)2576-2578
TidskriftLäkartidningen
Volym105
Utgåva nummer38
StatusPublished - 2008
PublikationskategoriForskning
Peer review utfördJa