Horizontal gene transfer: a critical view

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Horizontal gene transfer: a critical view. / Kurland, Charles; Canbäck, Björn; Berg, Otto.

I: Proceedings of the National Academy of Sciences, Vol. 100, Nr. 17, 2003, s. 9658-9662.

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TY - JOUR

T1 - Horizontal gene transfer: a critical view

AU - Kurland, Charles

AU - Canbäck, Björn

AU - Berg, Otto

PY - 2003

Y1 - 2003

N2 - It has been suggested that horizontal gene transfer (HGT) is the "essence of phylogeny." In contrast, much data suggest that this is an exaggeration resulting in part from a reliance on inadequate methods to identify HGT events. In addition, the assumption that HGT is a ubiquitous influence throughout evolution is questionable. Instead, rampant global HGT is likely to have been relevant only to primitive genomes. In modern organisms we suggest that both the range and frequencies of HGT are constrained most often by selective barriers. As a consequence those HGT events that do occur most often have little influence on genome phylogeny. Although HGT does occur with important evolutionary consequences, classical Darwinian lineages seem to be the dominant mode of evolution for modern organisms.

AB - It has been suggested that horizontal gene transfer (HGT) is the "essence of phylogeny." In contrast, much data suggest that this is an exaggeration resulting in part from a reliance on inadequate methods to identify HGT events. In addition, the assumption that HGT is a ubiquitous influence throughout evolution is questionable. Instead, rampant global HGT is likely to have been relevant only to primitive genomes. In modern organisms we suggest that both the range and frequencies of HGT are constrained most often by selective barriers. As a consequence those HGT events that do occur most often have little influence on genome phylogeny. Although HGT does occur with important evolutionary consequences, classical Darwinian lineages seem to be the dominant mode of evolution for modern organisms.

U2 - 10.1073/pnas.1632870100

DO - 10.1073/pnas.1632870100

M3 - Review article

VL - 100

SP - 9658

EP - 9662

JO - Proceedings of the National Academy of Sciences

T2 - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

SN - 1091-6490

IS - 17

ER -