Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Large, comprehensive studies of the risk for neurologic disorders among long-term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non-CNS childhood cancer survivors for neurologic disorders. We identified 15,967 5-year survivors of non-CNS childhood cancer diagnosed in Denmark, Iceland, Finland and Sweden in 1943–2008, and 151,118 matched population comparison subjects. In-patient discharge diagnoses of neurologic disorders were used to calculate relative risks (RRs) and absolute excess risks (AERs). A neurologic disorder was diagnosed in 755 of the survivors while 370 were expected, yielding a RR of 2.0 (95% confidence interval (CI) 1.9–2.2). The highest risks were found among survivors of neuroblastoma (4.1; 95% CI 3.2–5.3) and leukemia (2.8; 95% CI 2.4–3.2). The AER decreased from 331 (278–383) excess neurologic disorders per 100,000 person-years 5–9 years after diagnosis to 82 (46–118) ≥ 20 years after diagnosis. Epilepsy was the most common diagnosis (n = 229, 1.4% of all survivors), and significantly increased risks were seen among survivors of eight out of 12 types of childhood cancer. Survivors of neuroblastoma had remarkably high risks (RR ≥ 10) for hospitalization for paralytic syndromes and hydrocephalus, while survivors of leukemia had additional high risks for dementia and encephalopathy. In conclusion, survivors of non-CNS childhood cancer are at high risk for neurologic disorders, especially within the first decade after diagnosis. Therefore, intensive follow-up to identify those who require close management is needed.


  • Line Kenborg
  • Karen M. Linnet
  • Sofie de Fine Licht
  • Andrea Bautz
  • Anna S. Holmqvist
  • Laufey Tryggvadottir
  • Laura M. Madanat-Harjuoja
  • Marilyn Stovall
  • Carsten Heilmann
  • Vanna Albieri
  • Henrik Hasle
  • Jeanette F. Winther
  • ALiCCS study group
Enheter & grupper
Externa organisationer
  • Danish Cancer Society Research Center
  • Aarhus University Hospital
  • Skåne University Hospital
  • Icelandic Cancer Registry
  • University of Iceland
  • Finnish Cancer Registry
  • University of Texas
  • Copenhagen University Hospital

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
  • Pediatrik


Sidor (från-till)819-828
TidskriftInternational Journal of Cancer
Utgåva nummer3
Tidigt onlinedatum2019
StatusPublished - 2020
Peer review utfördJa