Hospital readmissions after limited vs. extended lymph node dissection during open and robot-assisted radical prostatectomy

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Purpose: Differences exist concerning when and how to perform lymph node dissection (LND) during radical prostatectomy due to lack of high-grade evidence to its safety and efficacy. We aimed to compare readmission rates between limited and extended LND during open radical prostatectomy (ORP) and robot-assisted radical prostatectomy (RARP). Materials and methods: We conducted a prospective trial of 3,706 eligible patients comparing ORP vs. RARP (LAPPRO). Six hundred and twenty-seven underwent concomitant LND. Data were retrieved for readmissions within 90 days from surgery from the Swedish Patient Registry. Causes for readmissions were classified according to the modified Clavien-Dindo classification system. We estimated risks for readmission stratified by type of LND and surgical approach. Results: We recorded 107 readmissions in 90 patients. The overall readmission rate was 14% (90/627). In the open group, extended LND had a higher, but not statistically significant readmission rate of 18% compared to 11% after limited LND (95%CI 0.87–3.01). In the robot-assisted group, readmissions after extended LND did not differ from limited LND (15% vs. 18%, 95%CI 0.49–1.61). RARP with limited LND showed a higher risk for any (RR 1.98, 95%CI [1.02–3.81]) as well as Clavien-Dindo grade 1 to 2 readmissions (RR 2.49, 95%CI [1.10–5.63]) compared to open approach with limited LND. Robot-assisted extended LND reduced the risk for Clavien-Dindo grade 3 to 5 complications leading to readmissions compared to the open approach by 59% (RR 0.41, 95%CI [0.19-0.87]). Conclusions: The risk for hospital readmission was similar when performing limited or extended LND during a radical prostatectomy. Robot-assisted technique for performing extended LND may decrease the risk for severe complications.

Detaljer

Författare
  • Stavros I. Tyritzis
  • Ulrica Wilderäng
  • Αnna Wallerstedt Lantz
  • Gunnar Steineck
  • J. Hugosson
  • Anders Bjartell
  • J. Stranne
  • Eva Haglind
  • Nils Peter Wiklund
Enheter & grupper
Externa organisationer
  • Karolinska Institute
  • Hygeia Hospital
  • Sahlgrenska Academy
  • Skåne University Hospital
  • Sahlgrenska University Hospital
  • Icahn School of Medicine at Mount Sinai
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kirurgi

Nyckelord

Originalspråkengelska
Sidor (från-till)5.e1-5.e8
TidskriftUrologic Oncology: Seminars and Original Investigations
Volym38
Utgåva nummer1
Tidigt onlinedatum2019
StatusPublished - 2020
PublikationskategoriForskning
Peer review utfördJa