Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

Detaljer

Författare
  • Elin Kindberg
  • Britt Akerlind
  • Christina Johnsen
  • Jenny Dahl Knudsen
  • Ole Heltberg
  • Göran Larson
  • Blenda Böttiger
  • Lennart Svensson
Externa organisationer
  • Danish Serum Institute, Copenhagen
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)2720-2
Antal sidor3
TidskriftJournal of Clinical Microbiology
Volym45
Utgåva nummer8
StatusPublished - 2007 aug
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa