HPV-16 L1 genes with inactivated negative RNA elements induce potent immune responses

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Introduction of point mutations in the 5' end of the human papillomavirus type 16 (HPV-16) L1 gene specifically inactivates negative regulatory RNA processing elements. DNA vaccination of C57B1/6 mice with the mutated L1 gene resulted in improved immunogenicity for both neutralizing antibodies as well as for broad cellular immune responses. Previous reports on the activation of L1 by codon optimization may be explained by inactivation of the regulatory RNA elements. The modified HPV-16 L1 DNA that induced anti-HPV-16 immunity may be seen as a complementary approach to protein subunit immunization against papillomavirus.

Detaljer

Författare
  • E Rollman
  • L Arnheim
  • B Collier
  • D Oberg
  • H Hall
  • J Klingstrom
  • Joakim Dillner
  • DV Pastrana
  • CB Buck
  • J Hinkula
  • B Wahren
  • S Schwartz
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Mikrobiologi inom det medicinska området

Nyckelord

Originalspråkengelska
Sidor (från-till)182-189
TidskriftVirology
Volym322
Utgåva nummer1
StatusPublished - 2004
PublikationskategoriForskning
Peer review utfördJa