Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells

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Bibtex

@article{f4f404ff4c1a41d8a794b5c5d4fc4ff2,
title = "Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells",
abstract = "The mammalian achaete-scute homologue, MASH-1, is crucial for early development of the sympathetic nervous system and is transiently expressed in sympathetic neuroblasts during embryogenesis. Here we report that the human homologue (HASH-1) was expressed in all analyzed cell lines (6/6) derived from the sympathetic nervous system tumor neuroblastoma. The majority of small-cell lung carcinoma (4/5) cell lines tested expressed HASH-1, while other nonneuronal/non-neuroendocrine cell lines were negative. Induced differentiation of neuroblastoma cells resulted in HASH-1 downregulation. This occurred concomitant with induction of neurite outgrowth and expression of the neuronal marker genes GAP-43 and neuropeptide Y. Constitutive expression of exogenous HASH-1 did not alter the capacity of the neuroblastoma cells to differentiate in response to differentiation-inducing agents. It is concluded that moderate HASH-1 expression does not compromise the capacity of these cells to differentiate.",
author = "H S{\"o}derholm and Eva {\"O}rtoft and Irja Johansson and June Ljungberg and Christer Larsson and H{\aa}kan Axelson and Sven P{\aa}hlman",
year = "1999",
doi = "10.1006/bbrc.1999.0314",
language = "English",
volume = "256",
pages = "557--563",
journal = "Biochemical and Biophysical Research Communications",
issn = "1090-2104",
publisher = "Elsevier",
number = "3",

}