Human cancer, the naked mole rat and faunal turnovers

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in ‘living fossil’ animals may help us find tools for cancer prevention and treatment.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk genetik

Nyckelord

Originalspråkengelska
Sidor (från-till)1652-1654
Antal sidor3
TidskriftCancer Medicine
Volym8
Utgivningsnummer4
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa