Hundreds of variants clustered in genomic loci and biological pathways affect human height

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Hundreds of variants clustered in genomic loci and biological pathways affect human height. / Allen, Hana Lango; Estrada, Karol; Lettre, Guillaume; Berndt, Sonja I.; Weedon, Michael N.; Rivadeneira, Fernando; Willer, Cristen J.; Jackson, Anne U.; Vedantam, Sailaja; Raychaudhuri, Soumya; Ferreira, Teresa; Wood, Andrew R.; Weyant, Robert J.; Segre, Ayellet V.; Speliotes, Elizabeth K.; Wheeler, Eleanor; Soranzo, Nicole; Park, Ju-Hyun; Yang, Jian; Gudbjartsson, Daniel; Heard-Costa, Nancy L.; Randall, Joshua C.; Qi, Lu; Smith, Albert Vernon; Maegi, Reedik; Pastinen, Tomi; Liang, Liming; Heid, Iris M.; Luan, Jian'an; Thorleifsson, Gudmar; Winkler, Thomas W.; Goddard, Michael E.; Lo, Ken Sin; Palmer, Cameron; Workalemahu, Tsegaselassie; Aulchenko, Yurii S.; Johansson, Asa; Zillikens, M. Carola; Feitosa, Mary F.; Esko, Tonu; Johnson, Toby; Ketkar, Shamika; Kraft, Peter; Mangino, Massimo; Prokopenko, Inga; Absher, Devin; Albrecht, Eva; Ernst, Florian; Glazer, Nicole L.; Hayward, Caroline; Hottenga, Jouke-Jan; Jacobs, Kevin B.; Knowles, Joshua W.; Kutalik, Zoltan; Monda, Keri L.; Polasek, Ozren; Preuss, Michael; Rayner, Nigel W.; Robertson, Neil R.; Steinthorsdottir, Valgerdur; Tyrer, Jonathan P.; Voight, Benjamin F.; Wiklund, Fredrik; Xu, Jianfeng; Zhao, Jing Hua; Nyholt, Dale R.; Pellikka, Niina; Perola, Markus; Perry, John R. B.; Surakka, Ida; Tammesoo, Mari-Liis; Altmaier, Elizabeth L.; Amin, Najaf; Aspelund, Thor; Bhangale, Tushar; Boucher, Gabrielle; Chasman, Daniel I.; Chen, Constance; Coin, Lachlan; Cooper, Matthew N.; Dixon, Anna L.; Gibson, Quince; Grundberg, Elin; Hao, Ke; Junttila, M. Juhani; Kaplan, Lee M.; Kettunen, Johannes; Koenig, Inke R.; Kwan, Tony; Lawrence, Robert W.; Levinson, Douglas F.; Lorentzon, Mattias; McKnight, Barbara; Morris, Andrew P.; Mueller, Martina; Ngwa, Julius Suh; Purcell, Shaun; Rafelt, Suzanne; Salem, Rany M.; Salvi, Erika; Sanna, Serena; Shi, Jianxin; Sovio, Ulla; Thompson, John R.; Turchin, Michael C.; Vandenput, Liesbeth; Verlaan, Dominique J.; Vitart, Veronique; White, Charles C.; Ziegler, Andreas; Almgren, Peter; Balmforth, Anthony J.; Campbell, Harry; Citterio, Lorena; De Grandi, Alessandro; Dominiczak, Anna; Duan, Jubao; Elliott, Paul; Elosua, Roberto; Eriksson, Johan G.; Freimer, Nelson B.; Geus, Eco J. C.; Glorioso, Nicola; Haiqing, Shen; Hartikainen, Anna-Liisa; Havulinna, Aki S.; Hicks, Andrew A.; Hui, Jennie; Igl, Wilmar; Illig, Thomas; Jula, Antti; Kajantie, Eero; Kilpelaeinen, Tuomas O.; Koiranen, Markku; Kolcic, Ivana; Koskinen, Seppo; Kovacs, Peter; Laitinen, Jaana; Liu, Jianjun; Lokki, Marja-Liisa; Marusic, Ana; Maschio, Andrea; Meitinger, Thomas; Mulas, Antonella; Pare, Guillaume; Parker, Alex N.; Peden, John F.; Petersmann, Astrid; Pichler, Irene; Pietilainen, Kirsi H.; Pouta, Anneli; Riddertrale, Martin; Rotter, Jerome I.; Sambrook, Jennifer G.; Sanders, Alan R.; Schmidt, Carsten Oliver; Sinisalo, Juha; Smit, Jan H.; Stringham, Heather M.; Walters, G. Bragi; Widen, Elisabeth; Wild, Sarah H.; Willemsen, Gonneke; Zagato, Laura; Zgaga, Lina; Zitting, Paavo; Alavere, Helene; Farrall, Martin; McArdle, Wendy L.; Nelis, Mari; Peters, Marjolein J.; Ripatti, Samuli; vVan Meurs, Joyce B. J.; Aben, Katja K.; Ardlie, Kristin G.; Beckmann, Jacques S.; Beilby, John P.; Bergman, Richard N.; Bergmann, Sven; Collins, Francis S.; Cusi, Daniele; den Heijer, Martin; Eiriksdottir, Gudny; Gejman, Pablo V.; Hall, Alistair S.; Hamsten, Anders; Huikuri, Heikki V.; Iribarren, Carlos; Kahonen, Mika; Kaprio, Jaakko; Kathiresan, Sekar; Kiemeney, Lambertus; Kocher, Thomas; Launer, Lenore J.; Lehtimaki, Terho; Melander, Olle; Mosley, Tom H., Jr.; Musk, Arthur W.; Nieminen, Markku S.; O'Donnell, Christopher J.; Ohlsson, Claes; Oostra, Ben; Palmer, Lyle J.; Raitakari, Olli; Ridker, Paul M.; Rioux, John D.; Rissanen, Aila; Rivolta, Carlo; Schunkert, Heribert; Shuldiner, Alan R.; Siscovick, David S.; Stumvoll, Michael; Toenjes, Anke; Tuomilehto, Jaakko; van Ommen, Gert-Jan; Viikari, Jorma; Heath, Andrew C.; Martin, Nicholas G.; Montgomery, Grant W.; Province, Michael A.; Kayser, Manfred; Arnold, Alice M.; Atwood, Larry D.; Boerwinkle, Eric; Chanock, Stephen J.; Deloukas, Panos; Gieger, Christian; Gronberg, Henrik; Hall, Per; Hattersley, Andrew T.; Hengstenberg, Christian; Hoffman, Wolfgang; Lathrop, G. Mark; Salomaa, Veikko; Schreiber, Stefan; Uda, Manuela; Waterworth, Dawn; Wright, Alan F.; Assimes, Themistocles L.; Barroso, Ines; Hofman, Albert; Mohlke, Karen L.; Boomsma, Dorret I.; Caulfield, Mark J.; Cupples, L. Adrienne; Erdmann, Jeanette; Fox, Caroline S.; Gudnason, Vilmundur; Gyllensten, Ulf; Harris, Tamara B.; Hayes, Richard B.; Jarvelin, Marjo-Ritta; Mooser, Vincent; Munroe, Patricia B.; Ouwehand, Willem H.; Penninx, Brenda W.; Pramstaller, Peter P.; Quertermous, Thomas; Rudan, Igor; Samani, Nilesh J.; Spector, Timothy D.; Voelzke, Henry; Watkins, Hugh; Wilson, James F.; Groop, Leif; Haritunians, Talin; Hu, Frank B.; Kaplan, Robert C.; Metspalu, Andres; North, Kari E.; Schlessinger, David; Wareham, Nicholas J.; Hunter, David J.; O'Connell, Jeffrey R.; Strachan, David P.; Schadt, H. -Erich; Thorsteinsdottir, Unnur; Peltonen, Leena; Uitterlinden, Andre G.; Visscher, Peter M.; Chatterjee, Nilanjan; Loos, Ruth J. F.; Boehnke, Michael; McCarthy, Mark I.; Ingelsson, Erik; Lindgren, Cecilia M.; Abecasis, Goncalo R.; Stefansson, Kari; Frayling, Timothy M.; Hirschhorn, Joel N.

I: Nature, Vol. 467, Nr. 7317, 2010, s. 832-838.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Allen, HL, Estrada, K, Lettre, G, Berndt, SI, Weedon, MN, Rivadeneira, F, Willer, CJ, Jackson, AU, Vedantam, S, Raychaudhuri, S, Ferreira, T, Wood, AR, Weyant, RJ, Segre, AV, Speliotes, EK, Wheeler, E, Soranzo, N, Park, J-H, Yang, J, Gudbjartsson, D, Heard-Costa, NL, Randall, JC, Qi, L, Smith, AV, Maegi, R, Pastinen, T, Liang, L, Heid, IM, Luan, J, Thorleifsson, G, Winkler, TW, Goddard, ME, Lo, KS, Palmer, C, Workalemahu, T, Aulchenko, YS, Johansson, A, Zillikens, MC, Feitosa, MF, Esko, T, Johnson, T, Ketkar, S, Kraft, P, Mangino, M, Prokopenko, I, Absher, D, Albrecht, E, Ernst, F, Glazer, NL, Hayward, C, Hottenga, J-J, Jacobs, KB, Knowles, JW, Kutalik, Z, Monda, KL, Polasek, O, Preuss, M, Rayner, NW, Robertson, NR, Steinthorsdottir, V, Tyrer, JP, Voight, BF, Wiklund, F, Xu, J, Zhao, JH, Nyholt, DR, Pellikka, N, Perola, M, Perry, JRB, Surakka, I, Tammesoo, M-L, Altmaier, EL, Amin, N, Aspelund, T, Bhangale, T, Boucher, G, Chasman, DI, Chen, C, Coin, L, Cooper, MN, Dixon, AL, Gibson, Q, Grundberg, E, Hao, K, Junttila, MJ, Kaplan, LM, Kettunen, J, Koenig, IR, Kwan, T, Lawrence, RW, Levinson, DF, Lorentzon, M, McKnight, B, Morris, AP, Mueller, M, Ngwa, JS, Purcell, S, Rafelt, S, Salem, RM, Salvi, E, Sanna, S, Shi, J, Sovio, U, Thompson, JR, Turchin, MC, Vandenput, L, Verlaan, DJ, Vitart, V, White, CC, Ziegler, A, Almgren, P, Balmforth, AJ, Campbell, H, Citterio, L, De Grandi, A, Dominiczak, A, Duan, J, Elliott, P, Elosua, R, Eriksson, JG, Freimer, NB, Geus, EJC, Glorioso, N, Haiqing, S, Hartikainen, A-L, Havulinna, AS, Hicks, AA, Hui, J, Igl, W, Illig, T, Jula, A, Kajantie, E, Kilpelaeinen, TO, Koiranen, M, Kolcic, I, Koskinen, S, Kovacs, P, Laitinen, J, Liu, J, Lokki, M-L, Marusic, A, Maschio, A, Meitinger, T, Mulas, A, Pare, G, Parker, AN, Peden, JF, Petersmann, A, Pichler, I, Pietilainen, KH, Pouta, A, Riddertrale, M, Rotter, JI, Sambrook, JG, Sanders, AR, Schmidt, CO, Sinisalo, J, Smit, JH, Stringham, HM, Walters, GB, Widen, E, Wild, SH, Willemsen, G, Zagato, L, Zgaga, L, Zitting, P, Alavere, H, Farrall, M, McArdle, WL, Nelis, M, Peters, MJ, Ripatti, S, vVan Meurs, JBJ, Aben, KK, Ardlie, KG, Beckmann, JS, Beilby, JP, Bergman, RN, Bergmann, S, Collins, FS, Cusi, D, den Heijer, M, Eiriksdottir, G, Gejman, PV, Hall, AS, Hamsten, A, Huikuri, HV, Iribarren, C, Kahonen, M, Kaprio, J, Kathiresan, S, Kiemeney, L, Kocher, T, Launer, LJ, Lehtimaki, T, Melander, O, Mosley, THJ, Musk, AW, Nieminen, MS, O'Donnell, CJ, Ohlsson, C, Oostra, B, Palmer, LJ, Raitakari, O, Ridker, PM, Rioux, JD, Rissanen, A, Rivolta, C, Schunkert, H, Shuldiner, AR, Siscovick, DS, Stumvoll, M, Toenjes, A, Tuomilehto, J, van Ommen, G-J, Viikari, J, Heath, AC, Martin, NG, Montgomery, GW, Province, MA, Kayser, M, Arnold, AM, Atwood, LD, Boerwinkle, E, Chanock, SJ, Deloukas, P, Gieger, C, Gronberg, H, Hall, P, Hattersley, AT, Hengstenberg, C, Hoffman, W, Lathrop, GM, Salomaa, V, Schreiber, S, Uda, M, Waterworth, D, Wright, AF, Assimes, TL, Barroso, I, Hofman, A, Mohlke, KL, Boomsma, DI, Caulfield, MJ, Cupples, LA, Erdmann, J, Fox, CS, Gudnason, V, Gyllensten, U, Harris, TB, Hayes, RB, Jarvelin, M-R, Mooser, V, Munroe, PB, Ouwehand, WH, Penninx, BW, Pramstaller, PP, Quertermous, T, Rudan, I, Samani, NJ, Spector, TD, Voelzke, H, Watkins, H, Wilson, JF, Groop, L, Haritunians, T, Hu, FB, Kaplan, RC, Metspalu, A, North, KE, Schlessinger, D, Wareham, NJ, Hunter, DJ, O'Connell, JR, Strachan, DP, Schadt, H-E, Thorsteinsdottir, U, Peltonen, L, Uitterlinden, AG, Visscher, PM, Chatterjee, N, Loos, RJF, Boehnke, M, McCarthy, MI, Ingelsson, E, Lindgren, CM, Abecasis, GR, Stefansson, K, Frayling, TM & Hirschhorn, JN 2010, 'Hundreds of variants clustered in genomic loci and biological pathways affect human height', Nature, vol. 467, nr. 7317, s. 832-838. https://doi.org/10.1038/nature09410

APA

Allen, H. L., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., ... Hirschhorn, J. N. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467(7317), 832-838. https://doi.org/10.1038/nature09410

CBE

Allen HL, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segre AV, Speliotes EK, Wheeler E, Soranzo N, Park J-H, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Smith AV, Maegi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Lo KS, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga J-J, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu J, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry JRB, Surakka I, Tammesoo M-L, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Junttila MJ, Kaplan LM, Kettunen J, Koenig IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon M, McKnight B, Morris AP, Mueller M, Ngwa JS, Purcell S, Rafelt S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A, Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJC, Glorioso N, Haiqing S, Hartikainen A-L, Havulinna AS, Hicks AA, Hui J, Igl W, Illig T, Jula A, Kajantie E, Kilpelaeinen TO, Koiranen M, Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki M-L, Marusic A, Maschio A, Meitinger T, Mulas A, Pare G, Parker AN, Peden JF, Petersmann A, Pichler I, Pietilainen KH, Pouta A, Riddertrale M, Rotter JI, Sambrook JG, Sanders AR, Schmidt CO, Sinisalo J, Smit JH, Stringham HM, Walters GB, Widen E, Wild SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall M, McArdle WL, Nelis M, Peters MJ, Ripatti S, vVan Meurs JBJ, Aben KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S, Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall AS, Hamsten A, Huikuri HV, Iribarren C, Kahonen M, Kaprio J, Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimaki T, Melander O, Mosley THJ, Musk AW, Nieminen MS, O'Donnell CJ, Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD, Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS, Stumvoll M, Toenjes A, Tuomilehto J, van Ommen G-J, Viikari J, Heath AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM, Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Gronberg H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Lathrop GM, Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL, Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Cupples LA, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes RB, Jarvelin M-R, Mooser V, Munroe PB, Ouwehand WH, Penninx BW, Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD, Voelzke H, Watkins H, Wilson JF, Groop L, Haritunians T, Hu FB, Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter DJ, O'Connell JR, Strachan DP, Schadt H-E, Thorsteinsdottir U, Peltonen L, Uitterlinden AG, Visscher PM, Chatterjee N, Loos RJF, Boehnke M, McCarthy MI, Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM, Hirschhorn JN. 2010. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 467(7317):832-838. https://doi.org/10.1038/nature09410

MLA

Vancouver

Allen HL, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010;467(7317):832-838. https://doi.org/10.1038/nature09410

Author

Allen, Hana Lango ; Estrada, Karol ; Lettre, Guillaume ; Berndt, Sonja I. ; Weedon, Michael N. ; Rivadeneira, Fernando ; Willer, Cristen J. ; Jackson, Anne U. ; Vedantam, Sailaja ; Raychaudhuri, Soumya ; Ferreira, Teresa ; Wood, Andrew R. ; Weyant, Robert J. ; Segre, Ayellet V. ; Speliotes, Elizabeth K. ; Wheeler, Eleanor ; Soranzo, Nicole ; Park, Ju-Hyun ; Yang, Jian ; Gudbjartsson, Daniel ; Heard-Costa, Nancy L. ; Randall, Joshua C. ; Qi, Lu ; Smith, Albert Vernon ; Maegi, Reedik ; Pastinen, Tomi ; Liang, Liming ; Heid, Iris M. ; Luan, Jian'an ; Thorleifsson, Gudmar ; Winkler, Thomas W. ; Goddard, Michael E. ; Lo, Ken Sin ; Palmer, Cameron ; Workalemahu, Tsegaselassie ; Aulchenko, Yurii S. ; Johansson, Asa ; Zillikens, M. Carola ; Feitosa, Mary F. ; Esko, Tonu ; Johnson, Toby ; Ketkar, Shamika ; Kraft, Peter ; Mangino, Massimo ; Prokopenko, Inga ; Absher, Devin ; Albrecht, Eva ; Ernst, Florian ; Glazer, Nicole L. ; Hayward, Caroline ; Hottenga, Jouke-Jan ; Jacobs, Kevin B. ; Knowles, Joshua W. ; Kutalik, Zoltan ; Monda, Keri L. ; Polasek, Ozren ; Preuss, Michael ; Rayner, Nigel W. ; Robertson, Neil R. ; Steinthorsdottir, Valgerdur ; Tyrer, Jonathan P. ; Voight, Benjamin F. ; Wiklund, Fredrik ; Xu, Jianfeng ; Zhao, Jing Hua ; Nyholt, Dale R. ; Pellikka, Niina ; Perola, Markus ; Perry, John R. B. ; Surakka, Ida ; Tammesoo, Mari-Liis ; Altmaier, Elizabeth L. ; Amin, Najaf ; Aspelund, Thor ; Bhangale, Tushar ; Boucher, Gabrielle ; Chasman, Daniel I. ; Chen, Constance ; Coin, Lachlan ; Cooper, Matthew N. ; Dixon, Anna L. ; Gibson, Quince ; Grundberg, Elin ; Hao, Ke ; Junttila, M. Juhani ; Kaplan, Lee M. ; Kettunen, Johannes ; Koenig, Inke R. ; Kwan, Tony ; Lawrence, Robert W. ; Levinson, Douglas F. ; Lorentzon, Mattias ; McKnight, Barbara ; Morris, Andrew P. ; Mueller, Martina ; Ngwa, Julius Suh ; Purcell, Shaun ; Rafelt, Suzanne ; Salem, Rany M. ; Salvi, Erika ; Sanna, Serena ; Shi, Jianxin ; Sovio, Ulla ; Thompson, John R. ; Turchin, Michael C. ; Vandenput, Liesbeth ; Verlaan, Dominique J. ; Vitart, Veronique ; White, Charles C. ; Ziegler, Andreas ; Almgren, Peter ; Balmforth, Anthony J. ; Campbell, Harry ; Citterio, Lorena ; De Grandi, Alessandro ; Dominiczak, Anna ; Duan, Jubao ; Elliott, Paul ; Elosua, Roberto ; Eriksson, Johan G. ; Freimer, Nelson B. ; Geus, Eco J. C. ; Glorioso, Nicola ; Haiqing, Shen ; Hartikainen, Anna-Liisa ; Havulinna, Aki S. ; Hicks, Andrew A. ; Hui, Jennie ; Igl, Wilmar ; Illig, Thomas ; Jula, Antti ; Kajantie, Eero ; Kilpelaeinen, Tuomas O. ; Koiranen, Markku ; Kolcic, Ivana ; Koskinen, Seppo ; Kovacs, Peter ; Laitinen, Jaana ; Liu, Jianjun ; Lokki, Marja-Liisa ; Marusic, Ana ; Maschio, Andrea ; Meitinger, Thomas ; Mulas, Antonella ; Pare, Guillaume ; Parker, Alex N. ; Peden, John F. ; Petersmann, Astrid ; Pichler, Irene ; Pietilainen, Kirsi H. ; Pouta, Anneli ; Riddertrale, Martin ; Rotter, Jerome I. ; Sambrook, Jennifer G. ; Sanders, Alan R. ; Schmidt, Carsten Oliver ; Sinisalo, Juha ; Smit, Jan H. ; Stringham, Heather M. ; Walters, G. Bragi ; Widen, Elisabeth ; Wild, Sarah H. ; Willemsen, Gonneke ; Zagato, Laura ; Zgaga, Lina ; Zitting, Paavo ; Alavere, Helene ; Farrall, Martin ; McArdle, Wendy L. ; Nelis, Mari ; Peters, Marjolein J. ; Ripatti, Samuli ; vVan Meurs, Joyce B. J. ; Aben, Katja K. ; Ardlie, Kristin G. ; Beckmann, Jacques S. ; Beilby, John P. ; Bergman, Richard N. ; Bergmann, Sven ; Collins, Francis S. ; Cusi, Daniele ; den Heijer, Martin ; Eiriksdottir, Gudny ; Gejman, Pablo V. ; Hall, Alistair S. ; Hamsten, Anders ; Huikuri, Heikki V. ; Iribarren, Carlos ; Kahonen, Mika ; Kaprio, Jaakko ; Kathiresan, Sekar ; Kiemeney, Lambertus ; Kocher, Thomas ; Launer, Lenore J. ; Lehtimaki, Terho ; Melander, Olle ; Mosley, Tom H., Jr. ; Musk, Arthur W. ; Nieminen, Markku S. ; O'Donnell, Christopher J. ; Ohlsson, Claes ; Oostra, Ben ; Palmer, Lyle J. ; Raitakari, Olli ; Ridker, Paul M. ; Rioux, John D. ; Rissanen, Aila ; Rivolta, Carlo ; Schunkert, Heribert ; Shuldiner, Alan R. ; Siscovick, David S. ; Stumvoll, Michael ; Toenjes, Anke ; Tuomilehto, Jaakko ; van Ommen, Gert-Jan ; Viikari, Jorma ; Heath, Andrew C. ; Martin, Nicholas G. ; Montgomery, Grant W. ; Province, Michael A. ; Kayser, Manfred ; Arnold, Alice M. ; Atwood, Larry D. ; Boerwinkle, Eric ; Chanock, Stephen J. ; Deloukas, Panos ; Gieger, Christian ; Gronberg, Henrik ; Hall, Per ; Hattersley, Andrew T. ; Hengstenberg, Christian ; Hoffman, Wolfgang ; Lathrop, G. Mark ; Salomaa, Veikko ; Schreiber, Stefan ; Uda, Manuela ; Waterworth, Dawn ; Wright, Alan F. ; Assimes, Themistocles L. ; Barroso, Ines ; Hofman, Albert ; Mohlke, Karen L. ; Boomsma, Dorret I. ; Caulfield, Mark J. ; Cupples, L. Adrienne ; Erdmann, Jeanette ; Fox, Caroline S. ; Gudnason, Vilmundur ; Gyllensten, Ulf ; Harris, Tamara B. ; Hayes, Richard B. ; Jarvelin, Marjo-Ritta ; Mooser, Vincent ; Munroe, Patricia B. ; Ouwehand, Willem H. ; Penninx, Brenda W. ; Pramstaller, Peter P. ; Quertermous, Thomas ; Rudan, Igor ; Samani, Nilesh J. ; Spector, Timothy D. ; Voelzke, Henry ; Watkins, Hugh ; Wilson, James F. ; Groop, Leif ; Haritunians, Talin ; Hu, Frank B. ; Kaplan, Robert C. ; Metspalu, Andres ; North, Kari E. ; Schlessinger, David ; Wareham, Nicholas J. ; Hunter, David J. ; O'Connell, Jeffrey R. ; Strachan, David P. ; Schadt, H. -Erich ; Thorsteinsdottir, Unnur ; Peltonen, Leena ; Uitterlinden, Andre G. ; Visscher, Peter M. ; Chatterjee, Nilanjan ; Loos, Ruth J. F. ; Boehnke, Michael ; McCarthy, Mark I. ; Ingelsson, Erik ; Lindgren, Cecilia M. ; Abecasis, Goncalo R. ; Stefansson, Kari ; Frayling, Timothy M. ; Hirschhorn, Joel N. / Hundreds of variants clustered in genomic loci and biological pathways affect human height. I: Nature. 2010 ; Vol. 467, Nr. 7317. s. 832-838.

RIS

TY - JOUR

T1 - Hundreds of variants clustered in genomic loci and biological pathways affect human height

AU - Allen, Hana Lango

AU - Estrada, Karol

AU - Lettre, Guillaume

AU - Berndt, Sonja I.

AU - Weedon, Michael N.

AU - Rivadeneira, Fernando

AU - Willer, Cristen J.

AU - Jackson, Anne U.

AU - Vedantam, Sailaja

AU - Raychaudhuri, Soumya

AU - Ferreira, Teresa

AU - Wood, Andrew R.

AU - Weyant, Robert J.

AU - Segre, Ayellet V.

AU - Speliotes, Elizabeth K.

AU - Wheeler, Eleanor

AU - Soranzo, Nicole

AU - Park, Ju-Hyun

AU - Yang, Jian

AU - Gudbjartsson, Daniel

AU - Heard-Costa, Nancy L.

AU - Randall, Joshua C.

AU - Qi, Lu

AU - Smith, Albert Vernon

AU - Maegi, Reedik

AU - Pastinen, Tomi

AU - Liang, Liming

AU - Heid, Iris M.

AU - Luan, Jian'an

AU - Thorleifsson, Gudmar

AU - Winkler, Thomas W.

AU - Goddard, Michael E.

AU - Lo, Ken Sin

AU - Palmer, Cameron

AU - Workalemahu, Tsegaselassie

AU - Aulchenko, Yurii S.

AU - Johansson, Asa

AU - Zillikens, M. Carola

AU - Feitosa, Mary F.

AU - Esko, Tonu

AU - Johnson, Toby

AU - Ketkar, Shamika

AU - Kraft, Peter

AU - Mangino, Massimo

AU - Prokopenko, Inga

AU - Absher, Devin

AU - Albrecht, Eva

AU - Ernst, Florian

AU - Glazer, Nicole L.

AU - Hayward, Caroline

AU - Hottenga, Jouke-Jan

AU - Jacobs, Kevin B.

AU - Knowles, Joshua W.

AU - Kutalik, Zoltan

AU - Monda, Keri L.

AU - Polasek, Ozren

AU - Preuss, Michael

AU - Rayner, Nigel W.

AU - Robertson, Neil R.

AU - Steinthorsdottir, Valgerdur

AU - Tyrer, Jonathan P.

AU - Voight, Benjamin F.

AU - Wiklund, Fredrik

AU - Xu, Jianfeng

AU - Zhao, Jing Hua

AU - Nyholt, Dale R.

AU - Pellikka, Niina

AU - Perola, Markus

AU - Perry, John R. B.

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PY - 2010

Y1 - 2010

N2 - Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.

AB - Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.

U2 - 10.1038/nature09410

DO - 10.1038/nature09410

M3 - Article

VL - 467

SP - 832

EP - 838

JO - Nature

T2 - Nature

JF - Nature

SN - 0028-0836

IS - 7317

ER -