Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

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Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study. / Clausen, Camilla T.; Hasle, Henrik; Holmqvist, Anna S.; Madanat-Harjuoja, Laura; Tryggvadottir, Laufey; Wesenberg, Finn; Bautz, Andrea; Winther, Jeanette F.; Licht, Sofie de Fine.

I: Acta Oncologica, Vol. 58, Nr. 2, 2019, s. 227-231.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Clausen, CT, Hasle, H, Holmqvist, AS, Madanat-Harjuoja, L, Tryggvadottir, L, Wesenberg, F, Bautz, A, Winther, JF & Licht, SDF 2019, 'Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study', Acta Oncologica, vol. 58, nr. 2, s. 227-231. https://doi.org/10.1080/0284186X.2018.1535187

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Author

Clausen, Camilla T. ; Hasle, Henrik ; Holmqvist, Anna S. ; Madanat-Harjuoja, Laura ; Tryggvadottir, Laufey ; Wesenberg, Finn ; Bautz, Andrea ; Winther, Jeanette F. ; Licht, Sofie de Fine. / Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study. I: Acta Oncologica. 2019 ; Vol. 58, Nr. 2. s. 227-231.

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TY - JOUR

T1 - Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

AU - Clausen, Camilla T.

AU - Hasle, Henrik

AU - Holmqvist, Anna S.

AU - Madanat-Harjuoja, Laura

AU - Tryggvadottir, Laufey

AU - Wesenberg, Finn

AU - Bautz, Andrea

AU - Winther, Jeanette F.

AU - Licht, Sofie de Fine

PY - 2019

Y1 - 2019

N2 - Background: Hyperthyroidism is a rare disorder which may negatively affect health and quality of life. Its occurrence in childhood cancer survivors has not previously been investigated in detail. Material and methods: In the hospital registers of the five Nordic countries, 32,944 childhood cancer survivors and 212,675 population comparisons were followed for the diagnosis of hyperthyroidism. Hospitalisation rates, standardised hospitalisation rate ratios and absolute excess risks were calculated with 95% confidence intervals (CI). Results: Hyperthyroidism was diagnosed in 131 childhood cancer survivors, yielding an overall relative risk of 1.6 (95% CI: 1.3–1.9) compared with population comparisons. The risk was greatest 1–5 years after the diagnosis of cancer and in survivors of thyroid cancers, neuroblastomas, acute lymphoblastic leukaemia and Hodgkin lymphoma. Sixty-seven percent of survivors with hyperthyroidism had tumours located in the head, neck or upper body and half of survivors with hyperthyroidism were irradiated with 77% of them in the head and neck area. Conclusion: Childhood cancer survivors are at an increased risk of hyperthyroidism, potentially resulting in non-endocrine morbidity.

AB - Background: Hyperthyroidism is a rare disorder which may negatively affect health and quality of life. Its occurrence in childhood cancer survivors has not previously been investigated in detail. Material and methods: In the hospital registers of the five Nordic countries, 32,944 childhood cancer survivors and 212,675 population comparisons were followed for the diagnosis of hyperthyroidism. Hospitalisation rates, standardised hospitalisation rate ratios and absolute excess risks were calculated with 95% confidence intervals (CI). Results: Hyperthyroidism was diagnosed in 131 childhood cancer survivors, yielding an overall relative risk of 1.6 (95% CI: 1.3–1.9) compared with population comparisons. The risk was greatest 1–5 years after the diagnosis of cancer and in survivors of thyroid cancers, neuroblastomas, acute lymphoblastic leukaemia and Hodgkin lymphoma. Sixty-seven percent of survivors with hyperthyroidism had tumours located in the head, neck or upper body and half of survivors with hyperthyroidism were irradiated with 77% of them in the head and neck area. Conclusion: Childhood cancer survivors are at an increased risk of hyperthyroidism, potentially resulting in non-endocrine morbidity.

U2 - 10.1080/0284186X.2018.1535187

DO - 10.1080/0284186X.2018.1535187

M3 - Article

VL - 58

SP - 227

EP - 231

JO - Acta Oncologica

T2 - Acta Oncologica

JF - Acta Oncologica

SN - 1651-226X

IS - 2

ER -