Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist

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title = "Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist",
abstract = "The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N-methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1 week of recovery was reduced 90 percent compared to that in saline-injected animals. The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.",
author = "Tadeusz Wieloch",
year = "1985",
month = "1",
day = "1",
doi = "10.1126/science.2996146",
language = "English",
volume = "230",
pages = "681--683",
journal = "Science (New York, N.Y.)",
issn = "1095-9203",
publisher = "American Association for the Advancement of Science",
number = "4726",