IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Methods: A population of 195 adolescents took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing. Results: Sensitization to airborne allergens was significantly more common than sensitization to food allergens, 43% vs. 14%, respectively. IgE response was significantly higher in airborne allergens among adolescents with rhinitis (p < 0.001) and eczema (p < 0.01). Among 53 children with allergic symptoms according to the questionnaire, 60% were sensitized. Sensitization to food allergens was found among those with rhinitis, but only to PR-10 proteins. None of the participants had IgE to seed storage proteins. Conclusion: The adolescents in this study, taken from a normal Swedish population, were mainly sensitized to grass pollen and rarely to specific food allergens. The major grass pollen allergen Phl p 1 was the main sensitizer, followed by Cyn d 1 and Phl p 2. Sixty-one percent reporting any allergic symptom were sensitized, and the allergen components associated with wheeze and rhinoconjunctivitis were Fel d 4, Der f 2 and Can f 5.


Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • Region Skåne
  • Uppsala universitet

Ämnesklassifikation (UKÄ)

  • Lungmedicin och allergi


TidskriftClinical and Molecular Allergy
StatusPublished - 2019
Peer review utfördJa

Relaterad forskningsoutput

Therese Sterner, 2020, Lund: Lund University, Faculty of Medicine. 84 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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Related projects

Therese Sterner, Ada Uldahl, Hampus Kiotseridis, Åke Svensson, Cecilia Svedman & Jonas Björk

2012/01/01 → …

Projekt: ForskningForskning i universitetssjukvården

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