IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies

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Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G > C (rs1800795) and -573G > C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on > 20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G > C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G > C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.


  • Cornelia Huth
  • Iris M. Heid
  • Caren Vollmert
  • Christian Gieger
  • Harald Grallert
  • Johanna K. Wolford
  • Birgit Langer
  • Barbara Thorand
  • Norman Klopp
  • Yasmin H. Hamid
  • Oluf Pedersen
  • Torben Hansen
  • Christa Meisinger
  • Angela Doring
  • Hannelore Lowel
  • Wolfgang Lieb
  • Christian Hengstenberg
  • Wolfgang Rathmann
  • Stephan Martin
  • Jeffrey W. Stephens
  • Helen Ireland
  • Hugh Mather
  • George J. Miller
  • Heather M. Stringham
  • Michael Boehnke
  • Jaakko Tuomilehto
  • Heiner Boeing
  • Matthias Mohlig
  • Joachim Spranger
  • Andreas Pfeiffer
  • Ingrid Wernstedt
  • Anders Niklason
  • Abel Lopez-Bermejo
  • Jose-Manuel Fernandez-Real
  • Robert L. Hanson
  • Luis Gallart
  • Joan Vendrell
  • Anastasia Tsiavou
  • Erifili Hatziagelaki
  • Steve E. Humphries
  • H. -Erich Wichmann
  • Christian Herder
  • Thomas Illig
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Endokrinologi och diabetes
Sidor (från-till)2915-2921
Utgåva nummer10
StatusPublished - 2006
Peer review utfördJa