Imaging brain microstructure with diffusion MRI: Practicality and applications

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Imaging brain microstructure with diffusion MRI : Practicality and applications. / Alexander, Daniel C.; Dyrby, Tim B.; Nilsson, Markus; Zhang, Hui.

I: NMR in Biomedicine, Vol. 32, Nr. 4, 2019, s. e3841.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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Alexander, Daniel C. ; Dyrby, Tim B. ; Nilsson, Markus ; Zhang, Hui. / Imaging brain microstructure with diffusion MRI : Practicality and applications. I: NMR in Biomedicine. 2019 ; Vol. 32, Nr. 4. s. e3841.

RIS

TY - JOUR

T1 - Imaging brain microstructure with diffusion MRI

T2 - Practicality and applications

AU - Alexander, Daniel C.

AU - Dyrby, Tim B.

AU - Nilsson, Markus

AU - Zhang, Hui

PY - 2019

Y1 - 2019

N2 - This article gives an overview of microstructure imaging of the brain with diffusion MRI and reviews the state of the art. The microstructure-imaging paradigm aims to estimate and map microscopic properties of tissue using a model that links these properties to the voxel scale MR signal. Imaging techniques of this type are just starting to make the transition from the technical research domain to wide application in biomedical studies. We focus here on the practicalities of both implementing such techniques and using them in applications. Specifically, the article summarizes the relevant aspects of brain microanatomy and the range of diffusion-weighted MR measurements that provide sensitivity to them. It then reviews the evolution of mathematical and computational models that relate the diffusion MR signal to brain tissue microstructure, as well as the expanding areas of application. Next we focus on practicalities of designing a working microstructure imaging technique: model selection, experiment design, parameter estimation, validation, and the pipeline of development of this class of technique. The article concludes with some future perspectives on opportunities in this topic and expectations on how the field will evolve in the short-to-medium term.

AB - This article gives an overview of microstructure imaging of the brain with diffusion MRI and reviews the state of the art. The microstructure-imaging paradigm aims to estimate and map microscopic properties of tissue using a model that links these properties to the voxel scale MR signal. Imaging techniques of this type are just starting to make the transition from the technical research domain to wide application in biomedical studies. We focus here on the practicalities of both implementing such techniques and using them in applications. Specifically, the article summarizes the relevant aspects of brain microanatomy and the range of diffusion-weighted MR measurements that provide sensitivity to them. It then reviews the evolution of mathematical and computational models that relate the diffusion MR signal to brain tissue microstructure, as well as the expanding areas of application. Next we focus on practicalities of designing a working microstructure imaging technique: model selection, experiment design, parameter estimation, validation, and the pipeline of development of this class of technique. The article concludes with some future perspectives on opportunities in this topic and expectations on how the field will evolve in the short-to-medium term.

KW - Brain

KW - Diffusion MRI

KW - Magnetic resonance imaging

KW - Microstructure imaging

KW - Neuroimaging

KW - Quantitative imaging

KW - Virtual histology

UR - http://www.scopus.com/inward/record.url?scp=85036579586&partnerID=8YFLogxK

U2 - 10.1002/nbm.3841

DO - 10.1002/nbm.3841

M3 - Review article

C2 - 29193413

AN - SCOPUS:85036579586

VL - 32

SP - e3841

JO - NMR in Biomedicine

JF - NMR in Biomedicine

SN - 0952-3480

IS - 4

ER -