Immunoglobulin from insulin-dependent diabetic children inhibits glucose-induced insulin release

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Immunoglobulin was separated from islet cel antibody positive plasma of six children with newly diagnosed insulin-dependent (type I) diabetes mellitus. The dynamics of insulin release in response to glucose and partially purified antibodies were determined in dispersed rat islet cells perifused on small columns of Biogel P-2 beads. After perifusion at 5.5 mmol/L D-glucose in the presence of healthy control immunoglobulin, the rate of insulin release increased in a biphasic manner after stimulation with 30 mmol/L D-glucose. In cells exposed to diabetic immunoglobulin, 30 mmol/L D-glucose had little, if any, effect on insulin release. These results suggest that islet cell antibodies in insulin-dependent diabetes may interfere with the insulin release mechanisms in the pancreatic B-cells.

Detaljer

Författare
Externa organisationer
  • Hagedorn Research Institute
Originalspråkengelska
Sidor (från-till)520-524
Antal sidor5
TidskriftDiabetes
Volym32
Utgåva nummer6 I
StatusPublished - 1983 jan 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa