Immunohistochemical localization and vascular effects of vasoactive intestinal polypeptide in skeletal muscle of the cat

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Immunohistochemical localization and vascular effects of vasoactive intestinal polypeptide in skeletal muscle of the cat. / Järhult, Johannes; Hellstrand, Per; Sundler, Frank.

I: Cell and Tissue Research, Vol. 207, Nr. 1, 1980, s. 55-64.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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T1 - Immunohistochemical localization and vascular effects of vasoactive intestinal polypeptide in skeletal muscle of the cat

AU - Järhult, Johannes

AU - Hellstrand, Per

AU - Sundler, Frank

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Vascular Physiology (013212034), Neuroendocrine Cell Biology (013212008)

PY - 1980

Y1 - 1980

N2 - Scattered vasoactive intestinal polypeptide (VIP)-immunoreactive nerves were found in the striated muscle of the hind limb of the cat, where they usually were associated with small blood vessels. VIP-immunoreactive nerves were also demonstrated in the sciatic nerve; after ligation an abundance of intensely immunoreactive VIP fibres were seen proximal to the ligation. Intraarterial infusion of VIP into isolated hind limb of the cat had dramatic effects on different sections of the vascular bed. Thus, VIP dilated the resistance vessels leading to a marked increment in muscle blood flow. VIP also relaxed the capacitance vessels causing regional pooling of blood; it increased the capillary surface area available for fluid exchange. Infusions of VIP at a dose of 8 microgram/min significantly inhibited the vasoconstriction, induced by electrical stimulation of the regional sympathetic nerves. It is suggested that local nervous release of VIP may act as a modulator of vascular tone in skeletal muscle.

AB - Scattered vasoactive intestinal polypeptide (VIP)-immunoreactive nerves were found in the striated muscle of the hind limb of the cat, where they usually were associated with small blood vessels. VIP-immunoreactive nerves were also demonstrated in the sciatic nerve; after ligation an abundance of intensely immunoreactive VIP fibres were seen proximal to the ligation. Intraarterial infusion of VIP into isolated hind limb of the cat had dramatic effects on different sections of the vascular bed. Thus, VIP dilated the resistance vessels leading to a marked increment in muscle blood flow. VIP also relaxed the capacitance vessels causing regional pooling of blood; it increased the capillary surface area available for fluid exchange. Infusions of VIP at a dose of 8 microgram/min significantly inhibited the vasoconstriction, induced by electrical stimulation of the regional sympathetic nerves. It is suggested that local nervous release of VIP may act as a modulator of vascular tone in skeletal muscle.

KW - Skeletal muscle (cat)

KW - Vasoactive intestinal polypeptide (VIP)

KW - Peptidergic nerves

KW - Vascular effects

U2 - 10.1007/BF00239329

DO - 10.1007/BF00239329

M3 - Article

VL - 207

SP - 55

EP - 64

JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 1432-0878

IS - 1

ER -