Immunohistochemical study of the soft tissue around long-term skin-penetrating titanium implants

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Bone-anchored percutaneous titanium implants have become a well-established clinical procedure with a low incidence of adverse reactions. However, passage through the skin leads to a breach in the barrier to exogenous pathogens. In the present study, monoclonal antibodies were used to investigate the distribution of lymphocyte subpopulations in the soft tissue around such implants. Eight biopsies from patients with clinically irritated skin, five from non-irritated and eight from skin without skin-penetrating implants were analysed. The number of immune cells was increased in the group of patients with skin penetration compared with patients without skin penetration. In the group with clinical irritation there was an increased level of B-lymphocytes compared with those without irritation. The data suggest that there is an immunological compensation for the mechanical loss in barrier function at these implants and that an antibody-mediated response is present at clinical signs of irritation.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Bioteknisk apparatteknik

Nyckelord

Originalspråkengelska
Sidor (från-till)611-616
TidskriftBiomaterials
Volym16
Utgåva nummer8
StatusPublished - 1995
PublikationskategoriForskning
Peer review utfördJa