Immunological Mechanisms Underlying the Genetic Predisposition to Severe Staphylococcus aureus Infection in the Mouse Model

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Host genetic variations play a significant role in conferring predisposition to infection. in this study, we examined the immune mechanisms underlying the host genetic predisposition to severe Staphylococcus aureus infection in different mouse strains. Whereas C57BL/6 mice were the most resistant in terms of control of bacterial growth and survival, A/J, DBA/2, and BALB/c mice were highly susceptible and succumbed to infection shortly after bacterial inoculation. Other strains (C3H/HeN, CBA, and C57BL/10) exhibited intermediate susceptibility levels. Susceptibility of mice to S. aureus was associated with an inability to limit bacterial growth in the kidneys and development of pathology. Resistance to S. aureus in C57BL/6 mice was dependent on innate immune mechanisms because Rag2-IL2R gamma(-/-) C57BL/6 mice, which are deficient in B, T, and NK cells, were also resistant to infection. Indeed, neutrophil depletion or inhibition of neutrophil recruitment rendered C57BL/6 mice completely susceptible to S. aureus, indicating that neutrophils are essential for the observed resistance. Although neutrophil function is not inhibited in A/J mice, expression of neutrophil chemoattractants; KC and MIP-2 peaked earlier in the kidneys of C57BL/6 mice than in A/J mice, indicating that a delay in neutrophil recruitment to the site of infection may underlie the increased susceptibility of A/J mice to S. aureus. (Am J Pathol 2008,173:1657-1668, DOI: 10.2353/ajpath.2008.080337)

Detaljer

Författare
  • Maren von Kockritz-Blickwede
  • Manfred Rohde
  • Sonja Oehmcke
  • Lloyd S. Miller
  • Ambrose L. Cheung
  • Heiko Herwald
  • Simon Foster
  • Eva Medina
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi
Originalspråkengelska
Sidor (från-till)1657-1668
TidskriftAmerican Journal of Pathology
Volym173
Utgivningsnummer6
StatusPublished - 2008
PublikationskategoriForskning
Peer review utfördJa