Impact of menstrual function on hormonal response to repeated bouts of intense exercise

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Impact of menstrual function on hormonal response to repeated bouts of intense exercise. / Melin, Anna K.; Ritz, Christian; Faber, Jens; Skouby, Sven; Pingel, Jessica; Sundgot-Borgen, Jorunn; Sjödin, Anders; Tornberg, Åsa B.

I: Frontiers in Physiology, Vol. 10, Nr. JUL, 942, 2019.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Melin, AK, Ritz, C, Faber, J, Skouby, S, Pingel, J, Sundgot-Borgen, J, Sjödin, A & Tornberg, ÅB 2019, 'Impact of menstrual function on hormonal response to repeated bouts of intense exercise', Frontiers in Physiology, vol. 10, nr. JUL, 942. https://doi.org/10.3389/fphys.2019.00942

APA

Melin, A. K., Ritz, C., Faber, J., Skouby, S., Pingel, J., Sundgot-Borgen, J., Sjödin, A., & Tornberg, Å. B. (2019). Impact of menstrual function on hormonal response to repeated bouts of intense exercise. Frontiers in Physiology, 10(JUL), [942]. https://doi.org/10.3389/fphys.2019.00942

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Author

Melin, Anna K. ; Ritz, Christian ; Faber, Jens ; Skouby, Sven ; Pingel, Jessica ; Sundgot-Borgen, Jorunn ; Sjödin, Anders ; Tornberg, Åsa B. / Impact of menstrual function on hormonal response to repeated bouts of intense exercise. I: Frontiers in Physiology. 2019 ; Vol. 10, Nr. JUL.

RIS

TY - JOUR

T1 - Impact of menstrual function on hormonal response to repeated bouts of intense exercise

AU - Melin, Anna K.

AU - Ritz, Christian

AU - Faber, Jens

AU - Skouby, Sven

AU - Pingel, Jessica

AU - Sundgot-Borgen, Jorunn

AU - Sjödin, Anders

AU - Tornberg, Åsa B.

PY - 2019

Y1 - 2019

N2 - Background: Strenous exercise stimulates the hypothalamic-pituitary (HP) axis in order to ensure homeostasis and promote anabolism. Furthermore, exercise stimulates a transient increase in the neurotrophin brain-derived neurotrophic factor (BDNF) suggested to mediate the anxiolytic effects of exercise. Athletes with secondary functional hypothalamic amenorrhea (FHA) have been reported to have lower BDNF, and a blunted HP axis response to exercise as athletes with overtraining syndrome. Aim: The aim of the study was to investigate the hormonal and BDNF responses to a two-bout maximal exercise protocol with four hours of recovery in between in FHA and eumenorrheic (EUM) athletes. Methods: Eumenorrheic (n = 16) and FHA (n = 14) endurance athletes were recruited from national teams and competitive clubs. Protocols included gynecological examination; body composition (DXA); 7-day assessment of energy availability; blood sampling pre and post the two exercises tests. Results: There were no differences between groups in hormonal responses to the first exercise bout. After the second exercise bout IGFBP-3 increased more in FHA compared with EUM athletes (2.1 ± 0.5 vs. 0.6 ± 0.6 µg/L, p = 0.048). There were non-significant trends toward higher increase in IGF-1 (39.3 ± 4.3 vs. 28.0 ± 4.6 µg/L, p = 0.074), BDNF (96.5 ± 22.9 vs. 34.4 ± 23.5 µg/L, p = 0.058), GH to cortisol ratio (0.329 ± 0.010 vs. 0.058 ± 0.010, p = 0.082), and decrease in IGF-1 to IGFBP-3 ratio (−2.04 ± 1.2 vs. 0.92 ± 1.22, p = 0.081) in athletes with FHA compared with EUM athletes. Furthermore, there was a non-significant trend toward a higher increase in prolactin to cortisol ratio in EUM athletes compared with athletes with FHA (0.60 ± 0.15 vs. 0.23 ± 0.15, p = 0.071). No differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function were found. Conclusion: No major differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function could be detected.

AB - Background: Strenous exercise stimulates the hypothalamic-pituitary (HP) axis in order to ensure homeostasis and promote anabolism. Furthermore, exercise stimulates a transient increase in the neurotrophin brain-derived neurotrophic factor (BDNF) suggested to mediate the anxiolytic effects of exercise. Athletes with secondary functional hypothalamic amenorrhea (FHA) have been reported to have lower BDNF, and a blunted HP axis response to exercise as athletes with overtraining syndrome. Aim: The aim of the study was to investigate the hormonal and BDNF responses to a two-bout maximal exercise protocol with four hours of recovery in between in FHA and eumenorrheic (EUM) athletes. Methods: Eumenorrheic (n = 16) and FHA (n = 14) endurance athletes were recruited from national teams and competitive clubs. Protocols included gynecological examination; body composition (DXA); 7-day assessment of energy availability; blood sampling pre and post the two exercises tests. Results: There were no differences between groups in hormonal responses to the first exercise bout. After the second exercise bout IGFBP-3 increased more in FHA compared with EUM athletes (2.1 ± 0.5 vs. 0.6 ± 0.6 µg/L, p = 0.048). There were non-significant trends toward higher increase in IGF-1 (39.3 ± 4.3 vs. 28.0 ± 4.6 µg/L, p = 0.074), BDNF (96.5 ± 22.9 vs. 34.4 ± 23.5 µg/L, p = 0.058), GH to cortisol ratio (0.329 ± 0.010 vs. 0.058 ± 0.010, p = 0.082), and decrease in IGF-1 to IGFBP-3 ratio (−2.04 ± 1.2 vs. 0.92 ± 1.22, p = 0.081) in athletes with FHA compared with EUM athletes. Furthermore, there was a non-significant trend toward a higher increase in prolactin to cortisol ratio in EUM athletes compared with athletes with FHA (0.60 ± 0.15 vs. 0.23 ± 0.15, p = 0.071). No differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function were found. Conclusion: No major differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function could be detected.

KW - Amenorrhea

KW - Brain derived neuronal factor

KW - Energy availability

KW - Female athlete

KW - Overtraining syndrome

U2 - 10.3389/fphys.2019.00942

DO - 10.3389/fphys.2019.00942

M3 - Article

C2 - 31417414

AN - SCOPUS:85070571785

VL - 10

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

IS - JUL

M1 - 942

ER -