Impact of tuberculosis exposure at home on mortality in children under 5 years of age in Guinea-Bissau

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Impact of tuberculosis exposure at home on mortality in children under 5 years of age in Guinea-Bissau. / Gomes, Victor F.; Andersen, Andreas; Wejse, Christian; Oliveira, Ines; Vieira, Fina J.; Joaquim, Luis Carlos; Vieira, Cesaltina S.; Aaby, Peter; Gustafson, Per.

I: Thorax, Vol. 66, Nr. 2, 2011, s. 163-167.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Gomes, VF, Andersen, A, Wejse, C, Oliveira, I, Vieira, FJ, Joaquim, LC, Vieira, CS, Aaby, P & Gustafson, P 2011, 'Impact of tuberculosis exposure at home on mortality in children under 5 years of age in Guinea-Bissau', Thorax, vol. 66, nr. 2, s. 163-167. https://doi.org/10.1136/thx.2010.141309

APA

Gomes, V. F., Andersen, A., Wejse, C., Oliveira, I., Vieira, F. J., Joaquim, L. C., ... Gustafson, P. (2011). Impact of tuberculosis exposure at home on mortality in children under 5 years of age in Guinea-Bissau. Thorax, 66(2), 163-167. https://doi.org/10.1136/thx.2010.141309

CBE

Gomes VF, Andersen A, Wejse C, Oliveira I, Vieira FJ, Joaquim LC, Vieira CS, Aaby P, Gustafson P. 2011. Impact of tuberculosis exposure at home on mortality in children under 5 years of age in Guinea-Bissau. Thorax. 66(2):163-167. https://doi.org/10.1136/thx.2010.141309

MLA

Vancouver

Author

Gomes, Victor F. ; Andersen, Andreas ; Wejse, Christian ; Oliveira, Ines ; Vieira, Fina J. ; Joaquim, Luis Carlos ; Vieira, Cesaltina S. ; Aaby, Peter ; Gustafson, Per. / Impact of tuberculosis exposure at home on mortality in children under 5 years of age in Guinea-Bissau. I: Thorax. 2011 ; Vol. 66, Nr. 2. s. 163-167.

RIS

TY - JOUR

T1 - Impact of tuberculosis exposure at home on mortality in children under 5 years of age in Guinea-Bissau

AU - Gomes, Victor F.

AU - Andersen, Andreas

AU - Wejse, Christian

AU - Oliveira, Ines

AU - Vieira, Fina J.

AU - Joaquim, Luis Carlos

AU - Vieira, Cesaltina S.

AU - Aaby, Peter

AU - Gustafson, Per

PY - 2011

Y1 - 2011

N2 - Objective To assess mortality related to exposure to tuberculosis (TB) at home among children in urban areas of Guinea-Bissau. Methods In four suburban areas included in the demographic surveillance system of the Bandim Health Project in Bissau, the mortality of children aged <5 years living with an adult with TB was compared with the mortality of children in the general population. Results Children <5 years of age exposed to an adult with intrathoracic TB had 66% higher mortality than unexposed children (HR 1.66, 95% CI 1.2 to 2.3). The risk was higher for children living in the same family as a TB case (HR 2.15, 95% CI 1.3 to 3.7) than for children living in the same house but not belonging to the same family as the TB case (HR 1.51, 95% CI 1.0 to 2.2). For children whose mother had TB, mortality was increased eightfold (HR 7.82, 95% CI 2.1 to 30). The risk of death was particularly increased from 6 months following exposure (HR 2.16, 95% CI 1.5 to 3.2) and the highest rate of excess mortality was found in children aged 3-4 years. Excess mortality was highest among children with close contact with an adult with sputum-positive pulmonary TB (HR 1.90, 95% CI 1.1 to 3.2), but contact with a sputum-negative case was also associated with increased mortality (HR 1.55, 95% CI 1.0 to 2.3). Adjusting for potential confounding factors did not change these results. The mortality among children living in the same houses 3 years earlier was not increased (HR 0.90, 95% CI 0.6 to 1.3). Conclusion Intimate family contact with a TB case represents a significant risk factor for child mortality in a low-income country.

AB - Objective To assess mortality related to exposure to tuberculosis (TB) at home among children in urban areas of Guinea-Bissau. Methods In four suburban areas included in the demographic surveillance system of the Bandim Health Project in Bissau, the mortality of children aged <5 years living with an adult with TB was compared with the mortality of children in the general population. Results Children <5 years of age exposed to an adult with intrathoracic TB had 66% higher mortality than unexposed children (HR 1.66, 95% CI 1.2 to 2.3). The risk was higher for children living in the same family as a TB case (HR 2.15, 95% CI 1.3 to 3.7) than for children living in the same house but not belonging to the same family as the TB case (HR 1.51, 95% CI 1.0 to 2.2). For children whose mother had TB, mortality was increased eightfold (HR 7.82, 95% CI 2.1 to 30). The risk of death was particularly increased from 6 months following exposure (HR 2.16, 95% CI 1.5 to 3.2) and the highest rate of excess mortality was found in children aged 3-4 years. Excess mortality was highest among children with close contact with an adult with sputum-positive pulmonary TB (HR 1.90, 95% CI 1.1 to 3.2), but contact with a sputum-negative case was also associated with increased mortality (HR 1.55, 95% CI 1.0 to 2.3). Adjusting for potential confounding factors did not change these results. The mortality among children living in the same houses 3 years earlier was not increased (HR 0.90, 95% CI 0.6 to 1.3). Conclusion Intimate family contact with a TB case represents a significant risk factor for child mortality in a low-income country.

U2 - 10.1136/thx.2010.141309

DO - 10.1136/thx.2010.141309

M3 - Article

VL - 66

SP - 163

EP - 167

JO - Thorax

T2 - Thorax

JF - Thorax

SN - 1468-3296

IS - 2

ER -